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NTIS 바로가기약학회지 = Yakhak hoeji, v.60 no.3, 2016년, pp.128 - 134
L1 cell adhesion molecule (L1CAM) is a cell surface molecule to initiate a variety of cellular responses through interacting with other cell adhesion molecules in a homophilic or heterophilic manner. Although its expression was found to be upregulated in some tumor cells, including cholangiocarcinom...
핵심어 | 질문 | 논문에서 추출한 답변 |
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염증이란? | 염증은 외부 병원균의 감염으로부터 우리 몸을 방어하는 면역계 최전선의 신체방어 기전으로, 통증, 발열, 부종, 발적, 신체의 기능저하 등의 증상을 나타낸다. 1) 염증이 신체의 방어 기전임에도 불구하고, 만성 염증은 염증성 자가면역질환 및 암 등 다양한 질병의 주요 요인으로 생각 되어져왔다. | |
염증의 증상은? | 염증은 외부 병원균의 감염으로부터 우리 몸을 방어하는 면역계 최전선의 신체방어 기전으로, 통증, 발열, 부종, 발적, 신체의 기능저하 등의 증상을 나타낸다. 1) 염증이 신체의 방어 기전임에도 불구하고, 만성 염증은 염증성 자가면역질환 및 암 등 다양한 질병의 주요 요인으로 생각 되어져왔다. | |
선천성 면역세포중 염증반응에 가장 중요한 역할을 하는 세포는? | 톨-유사 수용체의 감염균 인식을 통해 대식세포는 활성화되고, 그 결과 산화질소 (NO), 활성산소/활성질소(ROS/RNS), 프로스타글란딘(PG)-E2, 종양괴사인자(TNF)-α, 인터루킨(IL)-1β 및 인터루킨-6 등과 같은 다양한 염증성 물질을 발생한다. 3-5) 위에서 언급한 선천성 면역 세포 중, 염증반응에 가장 중요한 역할을 하는 세포는 대식세포 로서, 대식세포에서의 염증반응에 관한 연구는 분자세포학적으로 오랜 기간 동안 진행되어왔다. 대식세포가 표면 수용체를 통해 병원균을 인식하게 되면 염증반응이 개시되며, 수용체로부터 전해진 염증반응 신호를 시작으로 단백질 티로신 키나아제(protein tyrosine kinase; e. |
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