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Inhibition of the Calcineurin Pathway by Two Flavonoids Isolated from Miliusa sinensis Finet & Gagnep. 원문보기

Journal of microbiology and biotechnology, v.26 no.10, 2016년, pp.1696 - 1700  

Lee, Won Jeong (Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology) ,  Moon, Jae Sun (Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology) ,  Kim, Young Tae (Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology) ,  Bach, Tran The (Vietnam Academy of Science and Technology (VAST)) ,  Hai, Do Van (Vietnam Academy of Science and Technology (VAST)) ,  Kim, Sung Uk (Division of Systems Biology and Bioengineering, Korea Research Institute of Bioscience and Biotechnology)

Abstract ▼ AI-Helper 아이콘AI-Helper

In order to discover plant-derived signaling pathway inhibitors with antifungal properties, a two-component screening system utilizing the calcineurin and Hog1 mitogen-activated protein kinase pathways responsible for the virulence networks of Cryptococcus neoformans was employed, owing to the count...

주제어

#Miliusa sinensis Finet & Gagnep   #   #Cryptococcus neoformans   #virulence network   #two-component system   #calcineurin pathway  

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대상 데이터

  • Structural analyses with electrospray ionization mass spectrometry (ESI-MS) and various nuclear magnetic resonance (NMR) techniques, including 1H-1H COSY, HMQC, DEPT, and HMBC, revealed that both compounds had the same molecular formula C H O and molecular weight of 300. Based on the data, the compounds were identified as pashanone and 5-hydroxy- 6, 7-dimethoxyflavanone (Fig. 2). The MS and NMR data for both compounds were in agreement with previously published spectral data [10, 26].

이론/모형

  • The antifungal activities of the isolated pashanone and 5-hydroxy-6, 7-dimethoxyflavanone against various human pathogenic fungi were determined by MIC values using the broth dilution method from the CLSI. 5-Hydroxy-6, 7- dimethoxyflavanone showed potent antifungal activities against C.
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참고문헌 (28)

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    상세보기 crossref

  3. Bahn YS, Kojima K, Cox GM, Heitman J. 2006. A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans . Mol. Biol. Cell 17: 3122-3135. 

    상세보기 crossref

  4. Clinical and Laboratory Standards Institute. 2008. Reference Methods for Broth Dilution Antifungal Susceptibility Testing of Yeasts , pp. 1-20, 3rd Ed. CLSI Document M27-A3. Clinical and Laboratory Standards Institute, Pennsylvania. 

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  9. Huong DT, Luong DV, Thao TTP, Sung TV. 2005. A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). Pharmazie 60: 627-629. 

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  15. Kojima K, Bahn YS, Heitman J. 2006. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans . Microbiology 152: 591-604. 

    상세보기 crossref

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    상세보기 crossref

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    원문보기 상세보기 crossref

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    crossref

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  25. Stephen C, Lester S, Black W, Fyfe M, Raverty S. 2002. Multispecies outbreak of cryptococcosis on southern Vancouver Island, British Columbia. Can. Vet. J. 43: 792-794. 

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  27. Wu R, Ye Q, Chen NY, Zhang GL. 2001. A new norditerpene from Miliusa balansae Finet et Gagnep. Chin. Chem. Lett. 12: 247-248. 

  28. Zhang HJ, Ma C, Hung NV, Cuong NM, Tan GT, Santarsiero BD, et al. 2006. Miliusanes, a class of cytotoxic agents from Miliusa sinensis. J. Med. Chem. 49: 693-708. 

    상세보기 crossref

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