[논문]Metronomic Chemotherapy with Toceranib Phosphate for a Disseminated Histiocytic Sarcoma in a Miniature Schnauzer Dog

Hong, Hwaran; Lim, Seula; Shin, Hye-Ri; Choi, Ho-jung; Lee, Haebum; Song, Kun-Ho; Seo, Kyoung-Won

doi:10.17555/jvc.2017.12.34.6.441

Metronomic Chemotherapy with Toceranib Phosphate for a Disseminated Histiocytic Sarcoma in a Miniature Schnauzer Dog 원문보기

Journal of veterinary clinics = 한국임상수의학회지, v.34 no.6, 2017년, pp.441 - 444

Hong, Hwaran (College of Veterinary Medicine, Chungnam National University) , Lim, Seula (College of Veterinary Medicine, Chungnam National University) , Shin, Hye-Ri (College of Veterinary Medicine, Chungnam National University) , Choi, Ho-jung (College of Veterinary Medicine, Chungnam National University) , Lee, Haebum (College of Veterinary Medicine, Chungnam National University) , Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University) , Seo, Kyoung-Won (College of Veterinary Medicine, Chungnam National University)

Abstract ▼ AI-Helper

A 15-year-old spayed female Miniature Schnauzer was presented for unilateral foreleg lameness and pain. On physical examination, left elbow joint swelling and stiffness were identified. On a computed tomography (CT) scan, a periosteal reaction of the left humerus from the distal metaphysis to the epiphysis and cortical destruction of the medial condyle was observed. Based on blood tests, histopathology, and immunohistochemistry, it was concluded as a skeletal histiocytic sarcoma. Since the patient's pain was not controlled despite application of a fentanyl patch, a left forelimb amputation was decided upon as part of the palliative therapy. Metronomic chemotherapy with toceranib phosphate and pamidronate was initiated. Toceranib was administered for 3 months without the development of any adverse effects except mild neutropenia. However, 3 months after initiating treatment, the toceranib was discontinued due to moderate gastrointestinal disturbances. Over the next 2 months, a left mandibular bone mass and cortical bone destruction in the bilateral tibia and tarsal joint were identified on CT. The patient became unwilling to eat and was noted to have severe skeletal pain. The anorexia and lethargy were progressively worsening and the owner decided to euthanize the patient. A necropsy was performed and the patient was definitively diagnosed with disseminated histiocytic sarcoma based on histopathologic and immunohistochemical analyses. This report describes a Miniature Schnauzer dog with DHS managed with surgical removal and metronomic chemotherapy with toceranib that survived with an improved quality of life for 7 months.

주제어

AI 본문요약
AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

문제 정의

This report describes a case of DHS managed with surgery and metronomic chemotherapy with toceranib in a Miniature Schnauzer dog.

제안 방법

Metronomic chemotherapy with toceranib phosphate (2.5 mg/kg PO, Monday, Wednesday, Friday (MWF) protocol) and pamidronate (1 mg/kg, per month) were initiated.
One week following discontinuation of toceranib, the patient was noted to have severe skeletal pain including the right hindlimb and several combinations of analgesics such as fentanyl, morphine, gabapentin, carprofen, or tramadol were tried.

성능/효과

In conclusion, we reported a case which described a Miniature Schnauzer with DHS that was progressively affected in three limbs and the mandibular bone but was well managed with toceranib and palliative therapy and survived for 210 days with maintaining quality of life.

참고문헌 (18)

Abadie J, Hedan B, Cadieu E, De Brito C, Devauchelle P, Bourgain C, Parker HG, Vaysse A, Margaritte-Jeannin P, Galibert F, Ostrander EA, Andre C. Epidemiology, pathology, and genetics of histiocytic sarcoma in the Bernese mountain dog breed. J Hered 2009; 100: 19-27.

상세보기
Affolter VK, Moore PF. Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. Vet Pathol 2002; 39: 74-83.

상세보기
Bernabe LF, Portela R, Nguyen S, Kisseberth WC, Pennell M, Yancey MF, London CA. Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose. BMC Vet Res 2013; 9: 190.

상세보기
Cannon C, Borgatti A, Henson M, Husbands B. Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma. J Small Anim Pract 2015; 56: 425-429.

상세보기
Dervisis NG, Kiupel M, Qin Q, Cesario L. Clinical prognostic factors in canine histiocytic sarcoma. Vet Comp Oncol 2017; 15: 1171-1180.

상세보기
Friedrichs KR, Thomas C, Plier M, Andrews GA, Chavey PS, Young KM. Evaluation of serum ferritin as a tumor marker for canine histiocytic sarcoma. J Vet Intern Med 2010; 24: 904-911.

상세보기
Hayden DW, Waters DJ, Burke BA, Manivel JC. Disseminated Malignant Histiocytosis in a Golden Retriever: Clinicopathologic, Ultrastructural, and Immunohistochemical Findings. Vet Pathol 1993; 31: 256-64.
Lenz JA, Furrow E, Craig LE, Cannon CM. histiocytic sarcoma in 14 miniature schnauzers- a new breed presdisposition? J Small Anim Pract 2017; 58: 461-467.

상세보기
Liptak JM, Dernell WS, Straw RC, Rizzo SA, Lafferty MH, Withrow SJ. Proximal radial and distal humeral osteosarcoma in 12 dogs. J Am Anim Hosp Assoc 2004; 40: 461-467.

상세보기
London CA, Malpas PB, Wood-Follis SL, Boucher JF, Rusk AW, Rosenberg MP, Henry CJ, Mitchener KL, Klein MK, Hintermeister JG, Bergman PJ, Couto GC, Mauldin GN, Michels GM. Multi-center, placebo-controlled, doubleblind, randomized study of oral toceranib phosphate (SU- 11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clin Cancer Res 2009; 15: 3856-3865.

상세보기
London C, Mathie T, Stingle N, Clifford C, Haney S, Klein MK, Beaver L, Vickery K, Vail DM, Hershey B, Ettinger S, Vaughan A, Alvarez F, Hillman L, Kiselow M, Thamm D, Higginbotham ML, Gauthier M, Krick E, Phillips B, Ladue T, Jones P, Bryan J, Gill V, Novasad A, Fulton L, Carreras J, McNeill C, Henry C, Gillings S. Preliminary evidence for biologic activity of toceranib phosphate (Palladia(R)) in solid tumours. Vet Comp Oncol 2012; 10: 194-205.

상세보기
Plumb. D.C. Toceranib Phosphate. In: Plumb's Veterinary Drug Handbook, 8th ed. St. Paul: Wiley Blackwell. 2015: 1419-1422.
Schlick K, Aigelsreiter A, Pichler M, Reitter S, Neumeister P, Hoefler G, Beham-Schmid C, Linkesch W. Histiocytic sarcoma- targeted therapy: novel therapeutic options? A series of 4 cases. Onkologie 2012; 35: 447-450.

상세보기
Schultz RM, Puchalski SM, Kent M, Moore PF. Skeletal lesions of histiocytic sarcoma in nineteen dogs. Vet Radiol Ultrasound 2007; 48: 539-543.

상세보기
Treggiari E, Ressel L, Polton GA, Benoit J, Desmas I, Blackwood L. Clinical outcome, PDGFR ${\beta}$ and KIT expression in feline histiocytic disorders: a multicentre study. Vet Comp Oncol 2017; 15: 65-77.

상세보기
Ehrhart NP, Ryan SD, Fan TM. Tumors of the skeletal system. In: Withrow & MacEwn's Small Animal Clinical Oncology, 5th ed. St. Louis: Saunders Elsevier. 2013: 463-495.
Wouda RM, Miller ME, Chon E, Stein TJ. Clinical effects of vinorelbine administration in the management of various malignant tumor types in dogs: 58 cases (1997-2012). J Am Vet Med Assoc 2015; 246: 1230-1237.

상세보기
Zavodovskaya R, Liao AT, Jones CL, Yip B, Chien MB, Moore PF, Cheryl A. Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs. Am J Vet Res 2006; 67: 633-641.

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Metronomic Chemotherapy with Toceranib Phosphate for a Disseminated Histiocytic Sarcoma in a Miniature Schnauzer Dog 원문보기

Abstract ▼ AI-Helper

주제어

AI 본문요약
AI-Helper

문제 정의

제안 방법

성능/효과

참고문헌 (18)

이 논문을 인용한 문헌

저자의 다른 논문 :

관련 콘텐츠

원문 보기

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Metronomic Chemotherapy with Toceranib Phosphate for a Disseminated Histiocytic Sarcoma in a Miniature Schnauzer Dog 원문보기

Abstract ▼ AI-Helper

주제어

AI 본문요약 엑셀 다운로드 AI-Helper

문제 정의

제안 방법

성능/효과

참고문헌 (18)

이 논문을 인용한 문헌

저자의 다른 논문 :

Lim, Seula (1) Shin, Hye-Ri (1) 최호정 (38) 송근호 (104) 서경원 (43)

관련 콘텐츠

원문 보기

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

AI 본문요약
AI-Helper