[논문]방기복령탕(防己茯嶺湯)이 비만유도생쥐의 혈당 및 체지방개선에 미치는 영향

유형진; 이종하; 이수경; 송용선

doi:10.18325/jkmr.2017.27.1.1

방기복령탕(防己茯嶺湯)이 비만유도생쥐의 혈당 및 체지방개선에 미치는 영향
Effects of Bangkibokryeong-tang (Fangjifuling-tang) on the Reduction of Blood Glucose and Body Fat in High Fat Diet Induced Obese Mice 원문보기

Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, v.27 no.1, 2017년, pp.1 - 17

유형진 (대전자생한방병원) , 이종하 (원광대학교 한의과대학 한방재활의학교실) , 이수경 (원광대학교 한의과대학 한방재활의학교실) , 송용선 (원광대학교 한의과대학 한방재활의학교실)

Abstract ▼ AI-Helper

Objectives This study aimed to investigate the effect of Bangkibokryeong-tang (BBT, Fangjifuling-tang) on blood glucose and body fat in high-fat diet-induced obese mice. Methods The experimental animals were divided into five groups- normal diet-fed control (ND), high-fat diet-fed control (HFD), HFD+BBT 75, HFD+BBT 150, and HFD+olistat as a positive drug control group. Markers of obesity, such as body weight, organ weight, diet efficiency, and serum levels of total cholesterol, triglycerides, lipid content, leptin, adiponectin, glutamic oxaloacetic transaminase (GOT)/glutamic pyruvic transferase (GPT)/lactate dehydrogenase (LDH), blood glucose, and insulin, were measured. Furthermore, results of the oral glucose tolerance test and ${\alpha}-glucosidase$ inhibition activity were examined in obese mice. Results Mice treated with BBT demonstrate lower body and organ weight, and reduced weight gain and food efficiency than that in the HFD-only control group. In addition, BBT decreased lipid accumulation in the liver and the levels of enzymes such as GOT, GPT, and LDH in the serum. Furthermore, the levels of triglycerides, total cholesterol, low density lipoprotein (LDL), and leptin were decreased in the serum but the levels of high density lipoprotein (HDL) and adiponectin were increased in the BBT-treated group compared with the control group. The BBT-treated group also demonstrated decreased blood glucose and insulin concentrations induced by feeding on a high-fat diet and improved glucose tolerance. Conclusions Based on the results above, BBT may reduce body fat and hyperglycemia in HFD-induced obesity. This suggests that BBT may be clinically useful in the treatment of obesity.

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핵심어	질문	논문에서 추출한 답변
	비만이란?	비만은 체내에 필요한 에너지보다 과다 섭취되거나 섭취된 에너지보다 소비가 부족하여 초래되는 에너지 불균형의 상태로 호르몬의 변화, 유전, 정신, 사회경제적 요인 등 많은 요인이 복합적으로 관련되어 있으며 성인병과의 높은 연관성 때문에 중요한 건강문제로 대두되고 있다1).그러나 운동선수와 같이 체중은 많이 나가지만 근육량이많은 사람도 있으므로 단순체중만 가지고는 비만이라 할 수 없으며, 비만의 의학적인 정의를 내릴 때는 ‘체내에 지방이 과다하게 축적되어있는 상태’ 즉, 정상보다 체지방이 많은 상황을 말한다2).
	비만은 어떤 질환과 관련이 있는가?	비만은 또한 대사증후군, 지질대사 이상, 심혈관 질환,당뇨병 및 당대사 이상, 퇴행성 관절염, 불임, 암 등의 질환과 관련되어 있고1) 체내 과도한 지방의 축적 및 혈중지질농도의 증가는 당뇨병, 고혈압, 심혈관 질환을 포함한 만성질병을 유발하게 되는 원인으로 알려져 있으며,특히 피하조직 이외의 부위에 축적된 복부비만은 당 및지질대사에 장애를 초래하는 인슐린 비의존형 당뇨병, 고혈압, 고지혈증 등의 대사성질환과 심혈관 질환의 발병률과 사망률을 증가시킨다는 보고가 있다5-8).
	한의학적으로 비만의 치료법에는 어떤것이 있는가?	한의학적으로 비만은 ��內經��에 “膕肉堅皮滿者肥”로 최초로 언급된 이래 肥, 肥人, 肥白人, 肌膚盛, 肥貴人, 肥胖으로 표현되어 왔으며9), 원인은 穀氣勝元氣, 脾胃俱旺, 脾胃俱虛, 脾困邪勝, 痰飮, 氣虛, 血實氣虛, 華食, 數食甘味와 膏粱厚味가 있다고 하였다. 비만의 변증은 다양하게 제시될 수 있으나 한국 한의학연구원에서 제시한 肝鬱,食積, 陽虛, 脾虛, 痰飮, 瘀血 등 6개 유형이 주로 연구되고 있으며10) 이러한 비만의 치료법에는 韓藥, 體鍼, 藥鍼,耳鍼, 附缸, 氣功療法, 節食療法, 埋線, 溫熱療法 등이 이용되고 있다11,12).

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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