[논문]황정 약침의 비만 쥐에서의 국소 지방분해 효능 연구

김미혜; 최태양; 양웅모

황정 약침의 비만 쥐에서의 국소 지방분해 효능 연구
Effect of Polygonatum sibiricum Rehd. pharmacopuncture on localized adiposity in obese mice 원문보기

대한융합한의학회지 = Journal of Convergence Korean Medicine, v.1 no.1, 2021년, pp.17 - 24

김미혜 (경희대학교 한의과대학 융합한의과학교실) , 최태양 (경희대학교 한의과대학 융합한의과학교실) , 양웅모 (경희대학교 한의과대학 융합한의과학교실)

Abstract ▼ AI-Helper

Objectives: Excessive accumulation of fat on specific region, regarded as localized fat, is one of the serious problems and well-known risk factors of health. Recently, an interest in health and aesthetics is growing by treating lipolytic injection. Polygonatum sibiricum Rehd (PS) has been known to have anti-oxidant, -aging and -atherosclerotic effects. In this study, we investigated the lipolytic effects of PS pharmacopuncture in obese mice. Methods: Male C57BL/6J mice was fed with high fat diet to induce obesity for 12 weeks. PS pharmacopuncture was dissolved in saline by adjusting pH 7. 100 μL of PS pharmacopunture was injected subcutaneously into the left side inguinal fat pad, while saline was injected into the right side inguinal fat pad in mice as self-control. Samples were treated 3 times per weeks for 2 weeks. Results: PS pharmacopunture significantly decreased the inguinal fat weight compared to left side inguinal fat pad. Decrease rate of PS pharmacopuncture was about 21%. In addition, the diameter of adipocyte in inguinal fat tissues was significantly reduced by 17% compared to saline-injected side. There was no sign of toxicity through whole experiments. Conclusion: The present study indiates that PS pharmacopunture could be a material derived from natural herb as a lipolytic injection for decreasing localized fat.

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표/그림 (3)

그림 Fig. 1. Effects of PS on the inguinal fat in HFD-induced obese mice. (A) Representative morphological images of inguinal fat tissues. Red dotted lines from knee to tail indicate the designated regions of inguinal fat. (B) Fat weight (mg) of inguinal fat tissues. (C) Relative weight ratio of inguinal fat collected from knee to tail based on line of ventral spine at the end of the experiment. Relative ratio of fat weight after PS pharmacopuncture treatment (PS) was calculated when the saline-treated fat weight (Vehicle) was normalized to 1. Quantitative data are presented as the mean ± standard error of the mean. *p<0.05 compared with each saline-treated side (Vehicle).
그림 Fig. 2. Effects of PS on histological changes of inguinal fat tissues in HFD-induced obese mice. (A) Representative histological images of inguinal fat tissues. Sections were stained by H&E and viewed under a microscope (magnification, x400). (B) Value of fat diameter in inguinal fat quantified using Image J software. (C) Relative value of fat diameter in inguinal fat measured compared with Vehicle. The fat diameter in the saline-treated side (Vehicle) was normalized to 1 and that in the PS pharmacopuncture-treated side (PS) was calculated as the relative intensity. Quantitative data are shown as the mean ± standard error of the mean. ***p<0.001 compared with each saline-treated side (Vehicle).
그림 Fig. 3. Effects of PS on body weight in HFD-induced obese mice.

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황정 약침의 비만 쥐에서의 국소 지방분해 효능 연구
Effect of Polygonatum sibiricum Rehd. pharmacopuncture on localized adiposity in obese mice 원문보기

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황정 약침의 비만 쥐에서의 국소 지방분해 효능 연구 Effect of Polygonatum sibiricum Rehd. pharmacopuncture on localized adiposity in obese mice 원문보기

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황정 약침의 비만 쥐에서의 국소 지방분해 효능 연구
Effect of Polygonatum sibiricum Rehd. pharmacopuncture on localized adiposity in obese mice 원문보기