[논문]수면박탈로 유도한 Hippocampus Dentate gyrus의 산화 스트레스에 대한 백합, 연자육의 신경세포보호효과

최미혜; 박인식

doi:10.15188/kjopp.2017.02.31.1.65

수면박탈로 유도한 Hippocampus Dentate gyrus의 산화 스트레스에 대한 백합, 연자육의 신경세포보호효과
Neuroprotective Effect of Lilii bulbus, Nelumbins semen on the Sleep Deprivation-induced Oxidative Stress in the Hippocampus Dentate Gyrus 원문보기

동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, v.31 no.1, 2017년, pp.65 - 74

최미혜 (동국대학교 한의과대학 해부학교실) , 박인식 (동국대학교 한의과대학 해부학교실)

Abstract ▼ AI-Helper

Sleep deprivation is an extremely common event in today's society. It has caused learning cognitive skill deterioration and poor concentration, increased disease such as heart disease, diabetes and obesity, sexual function decrease, infertility increase, depression and autonomic nervous system disorder. Sleep deprivation-induced stress caused NADPH oxidase and oxidative stress. And this oxidative stress induces apoptosis. Lilii bulbus and Nelumbins semen are known to mental and physical relaxation effects. In this study, we induced sleep deprivation(SD) in Sprague-Dawley rats in water for 5 days and thereafter administered orally L. bulbus and N. semen for 5 days. Brain tissues were observed by histochemical, immunohistochemical and tunel staining. The immunoreactives of Tumor necrosis factor ${\alpha}$, Neuronal nitric oxide synthases, Phospho-SAPK/JNK and gp91-phox of the L. bulbus administered group and N. semen administered group were weaker than those of sleep deprivation group. In the L. bulbus administered group and N. semen administered group, apoptosis was decreased than that of sleep deprivation group. Proapoptotic p53, Bax, Cleaved caspase 3 immunoreactives of the administered group were weaker than those of sleep deprivation group, whereas anti-apoptotic Bcl-2 immunoreactity was stronger in the L. bulbus administered group and N. semen administered group. Antioxidant mechanism such as DJ-1, superoxide dismutase 1, Nuclear factor-like 2 immunoreactives of the L. bulbus and N. semen administered group were stronger than those of sleep deprivation group. These results demonstrate that L. bulbus, N. semen had the neuroprotective effects on the sleep deprivation-induced oxidative stress in the hippocampus.

주제어

질의응답

핵심어	질문	논문에서 추출한 답변
	기존에 알려진 연자육은 어떠한 작용을 하는가?	비(脾), 신(腎), 심(心)으로 귀경한다. 비를 보하여 설사를 완화하여주고(補脾止瀉), 신장을 강화하여 강장작용과 대하를 완화(益腎澁精, 止帶)하는 작용을 한다. 또 심을 보양하여 신경을 안정(養心安神)시키는 작용을 한다6). 최근 연구결과에 의하면 연자육은 고혈압과 부정맥 같은 심장혈관 질환 치료 작용과 항암제, 이뇨제, 피부질환 치료 효능, 멜라닌 합성 저해효과, 항산화 효과와 뇌신경 보호 활성효과가 있다고 보고되었다9,14-16).
	최근에 알려진 백합의 작용에는 어떠한 것들이 있는가?	양음윤폐(養陰潤肺), 청심제번(淸心除煩)하여 심신을 안정시키는(寧心安神) 작용을 한다6). 최근 연구결과에 따르면 백합은 항피로, 항우울, 항종양, 혈당강하, 항염, 항균, 항산화, 면역조절, 지해(止咳)작용이 뛰어난 것으로 보고되었다7-9).
	백합이란 무엇인가?	백합(Lilii bulbus )은 참나리 Lilium lancifolium Thunberg, 백합(百合) Lilium brownie var. viridulun Baker 또는 큰솔나리 Lilium pumilum DC. (백합과 Liliaceae)의 비늘줄기로5) 맛이 감(甘)하고 성질은 한(寒)하며 심(心)과 폐(肺)로 귀경한다. 양음윤폐(養陰潤肺), 청심제번(淸心除煩)하여 심신을 안정시키는(寧心安神) 작용을 한다6).

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저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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