Jung, Bong-Kwang
(Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
,
Song, Hyemi
(Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
,
Lee, Sang-Eun
(Division of Malaria and Parasitic Diseases, Korea National Research Institute of Health, Korea Center for Disease Control and Prevention)
,
Kim, Min-Jae
(Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
,
Cho, Jaeeun
(Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
,
Shin, Eun-Hee
(Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
,
Chai, Jong-Yil
(Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine)
The seroprevalence of human toxoplasmosis has been increasing in Korea, and it is controversial whether cats are an important infection source or not. This study was performed to evaluate the seroprevalence of Toxoplasma gondii infection in a high risk group (cat sitters) and to determine the possib...
The seroprevalence of human toxoplasmosis has been increasing in Korea, and it is controversial whether cats are an important infection source or not. This study was performed to evaluate the seroprevalence of Toxoplasma gondii infection in a high risk group (cat sitters) and to determine the possible importance of cats as an infection source in Korea. Risk factors, including the age, sex, and diet of cat sitters, their contact experience and contact frequency with stray cats, and origin, number, and outdoor activity of their pet cats, were analyzed using structured questionnaires. A total of 673 serum samples from people who have frequent contact with cats (high risk group) and 1,114 samples from general people (low risk group) were examined for specific IgG antibodies against T. gondii by ELISA. The results revealed that the overall seroprevalence of T. gondii infection was 7.4% (n=1,787). The seroprevalence among low risk group was 8.0% (89/1,114), whereas that among high risk group was rather lower 6.4% (43/673), though this difference was statistically not significant (P=0.211). Among the risk factors, only the outdoor activity of pet cats was important; people having cats with outdoor activities revealed 2 times higher seroprevalence than people having cats with only indoor activities (P=0.027). In conclusion, the seroprevalence of T. gondii was not significantly different between the high risk group and low risk group, and the importance of cats as a source of infection in Korea is questionable.
The seroprevalence of human toxoplasmosis has been increasing in Korea, and it is controversial whether cats are an important infection source or not. This study was performed to evaluate the seroprevalence of Toxoplasma gondii infection in a high risk group (cat sitters) and to determine the possible importance of cats as an infection source in Korea. Risk factors, including the age, sex, and diet of cat sitters, their contact experience and contact frequency with stray cats, and origin, number, and outdoor activity of their pet cats, were analyzed using structured questionnaires. A total of 673 serum samples from people who have frequent contact with cats (high risk group) and 1,114 samples from general people (low risk group) were examined for specific IgG antibodies against T. gondii by ELISA. The results revealed that the overall seroprevalence of T. gondii infection was 7.4% (n=1,787). The seroprevalence among low risk group was 8.0% (89/1,114), whereas that among high risk group was rather lower 6.4% (43/673), though this difference was statistically not significant (P=0.211). Among the risk factors, only the outdoor activity of pet cats was important; people having cats with outdoor activities revealed 2 times higher seroprevalence than people having cats with only indoor activities (P=0.027). In conclusion, the seroprevalence of T. gondii was not significantly different between the high risk group and low risk group, and the importance of cats as a source of infection in Korea is questionable.
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제안 방법
As the control group, sera of 1,114 randomly selected healthy volunteers (a few of them may have contact with cats) who visited the Korea Association of Health Promotion for health check-up were included for the serological assay. The questionnaires comprised of various items, including how to acquire their own cats, the origin of cats, and the lifestyle of cats, in order to get information on possible routes of T. gondii infection. All of the blood and sera were stored at -80˚C until analyzed.
성능/효과
We regret that we could not discriminate them from others and exclude such subjects. In addition, no statistically significant differences were noted in the seropositivity of people having different risk factors, including the age, gender, and type of diet of cat sitters, and their experience of contact with stray cats, as well as the origin and number of pet cats and the duration of living with cats (Tables 2, 3). Only 1 factor, i.
211) (Table 1). The questionnaire analysis revealed little meaningful differences between the seropositivity of high risk group and low risk group in respects of cat sitter characteristics (Table 2) and cat characteristics (Table 3). The frequency of contact with cats, in particular, 2-5 times in a week, appeared to be statistically significant in cat sitters; however, the overall P-value for the frequency of contact with cats (4 options) was 0.
The results of our study indicated that, in our study setting, the seroprevalence of toxoplasmosis among cat sitters (high risk group) was not higher compared to that in general people (low risk group). Among the subjected general people, a few people who were rearing or who reared pet cats may have been included.
The results revealed that the seroprevalence of T. gondii infection in high risk group (6.4%, 43/673) was rather slightly lower than that of low risk group (8.0%, 89/1,114) (Table 1). However, the difference was statistically not significant (P= 0.
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