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Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy 원문보기

Molecules and cells, v.40 no.7, 2017년, pp.441 - 449  

Ji, Chang Hoon (Protein Metabolism Medical Research Center and Department of Biomedical Sciences, Seoul National University) ,  Kwon, Yong Tae (Protein Metabolism Medical Research Center and Department of Biomedical Sciences, Seoul National University)

Abstract AI-Helper 아이콘AI-Helper

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system (UPS) and the autophagy-lysosome system (hereafter autophagy). The UPS is a selective proteolytic system in which substrates are recognized and tagged with ubiquitin for processive degradation by the proteasom...

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  • Moreover, considering the variety of post-translational modifications available to not only substrates and regulatory proteins but also ubiquitin itself, the mere presence or type of ubiquitin chain linkages is unlikely adequate to fully account for thorough understand-ing proteasomal or autophagic degrons. Further studies are needed to understand how the ubiquitin code is deciphered for autophagic degradation.
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