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공업화학 = Applied chemistry for engineering, v.28 no.4, 2017년, pp.383 - 396
김봉근 (명지대학교 화학공학과) , 여도경 (명지대학교 화학공학과) , 나현빈 (명지대학교 화학공학과)
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The photothermal therapy is a method of cell ablation using the heat converted from the incident light by photothermal transducers. It offers a selective treatment to desired abnormal cells, in particular, tumor tissues. Among various photothermal agents, gold nanoparticles (Au NPs) have received en...
| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 금의 안전성과 관련된 특징은 무엇인가? | 그리고 유기 염료 분자에 비해 약 백만 배 정 도 많은 빛을 흡수할 수 있고, 흡수한 빛을 거의 100% 열로 변환한다 [17]. 또한 입자 표면을 화학적으로 개질하기도 쉬우며[18], 금 자체가 화학적으로 비활성이기 때문에 유의미한 정도의 세포독성을 나타내 지 않는다[19]. | |
| 광열치료에 고출력 레이저를 이용할 수 없는 이유는 무엇인가? | 정상세포와 비교해서 빠르게 자라나는 암세포는 혈액의 공급이 좋지 못해 열에 대한 저항성이 나쁘므로, 열은 암세포를 선별적으로 사멸시킬 수 있는 효율적인 도구라 할 수 있다[4]. 그러나 열을 발생시키기 위해 고출력의 레이저를 직접 피부에 조사한다면 과열로 인한 화상, 수포, 통증과 같은 병리적인 현상을 야기할 수 있다. 레이저에 의한 열 발생은 조사 시간과 온도에 의해 결정되므로 이 두 요소의 조합이 문턱값 이하로 유지된다면 피부 손 상을 피할 수 있으나 그렇게 된다면 병소에서 열이 제대로 발생되지 않아 암세포 또한 사멸하지 않을 가능성이 크다[5]. | |
| 광열치료는 무엇인가? | 광열치료(photothermal therapy)는 빛을 조사해 열을 발생시킴으로써, 국소적인 가열을 통해 비정상적인 세포, 특히 암세포를 선택적으로 사멸시키는 치료법이다[1-3]. 정상세포와 비교해서 빠르게 자라나는 암세포는 혈액의 공급이 좋지 못해 열에 대한 저항성이 나쁘므로, 열은 암세포를 선별적으로 사멸시킬 수 있는 효율적인 도구라 할 수 있다[4]. |
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