Objectives : The objective of this study was to evaluate the effect of Dokhwaljihwang-tang (DJT) intravenous pharmacopuncture on cisplatin-induced emesis and gastric mobility disorder in Wistar rats. Methods : Thirty rats were randomly divided into six groups and cisplatin was administered to all gr...
Objectives : The objective of this study was to evaluate the effect of Dokhwaljihwang-tang (DJT) intravenous pharmacopuncture on cisplatin-induced emesis and gastric mobility disorder in Wistar rats. Methods : Thirty rats were randomly divided into six groups and cisplatin was administered to all groups except the normal group. The cisplatin group (n=5) received a cisplatin injection only. The saline group (n=5) was injected with cisplatin followed by 0.4 mL of saline. Groups DJT-1, DJT-2, and DJT-3 were injected with cisplatin, followed by 0.315 g/kg, 0.104 g/kg, and 0.034 g/kg of DJT, respectively. Body weight, food intake, and kaolin intake of rats were measured 12 h, 24 h, and 36 h after cisplatin injection. Residual food in the stomach was measured 48 h after cisplatin injection. Results : There was no significant difference in weight. The food intake was not significantly different 12 h after cisplatin administration. All groups except the normal group showed significantly decreased food intake after 24 h. After 36 h, food intake was not significantly different between groups DJT-1, DJT-2, and DJT-3 and the normal group. The kaolin intake of groups DJT-1 and DJT-2 was significantly decreased at 12 h and 24 h after cisplatin injection. Kaolin intake and residual food in the stomach were significantly decreased in groups DJT-1, DJT-2, and DJT-3. Conclusion : In a Wistar rat model, DJT intravenous pharmacopuncture is suggested to be effective for cisplatin-induced emesis and gastric motility disorder. In the future, it is necessary to study the mechanism and chemical composition of each individual constitutive drug.
Objectives : The objective of this study was to evaluate the effect of Dokhwaljihwang-tang (DJT) intravenous pharmacopuncture on cisplatin-induced emesis and gastric mobility disorder in Wistar rats. Methods : Thirty rats were randomly divided into six groups and cisplatin was administered to all groups except the normal group. The cisplatin group (n=5) received a cisplatin injection only. The saline group (n=5) was injected with cisplatin followed by 0.4 mL of saline. Groups DJT-1, DJT-2, and DJT-3 were injected with cisplatin, followed by 0.315 g/kg, 0.104 g/kg, and 0.034 g/kg of DJT, respectively. Body weight, food intake, and kaolin intake of rats were measured 12 h, 24 h, and 36 h after cisplatin injection. Residual food in the stomach was measured 48 h after cisplatin injection. Results : There was no significant difference in weight. The food intake was not significantly different 12 h after cisplatin administration. All groups except the normal group showed significantly decreased food intake after 24 h. After 36 h, food intake was not significantly different between groups DJT-1, DJT-2, and DJT-3 and the normal group. The kaolin intake of groups DJT-1 and DJT-2 was significantly decreased at 12 h and 24 h after cisplatin injection. Kaolin intake and residual food in the stomach were significantly decreased in groups DJT-1, DJT-2, and DJT-3. Conclusion : In a Wistar rat model, DJT intravenous pharmacopuncture is suggested to be effective for cisplatin-induced emesis and gastric motility disorder. In the future, it is necessary to study the mechanism and chemical composition of each individual constitutive drug.
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문제 정의
However, to the best of our knowledge, no such study has been performed. The objective of the present study was to evaluate the effect of DJT intravenous pharmacopuncture on cisplatin-induced emesis and gastric mobility disorder in Wistar rats.
가설 설정
. Based on the positive outcomes of previous intravenous pharmacopuncture studies, wehypothesized that DJT intravenousacupuncture was likely to be effective in treating CINV. However, to the best of our knowledge, no such study has been performed.
제안 방법
Thirty Wistar rats were randomly divided into six groups: normal, cisplatin, saline, DJT-1, DJT2, and DJT-3 (five rats in each group). The normal group did not undergo any treatment.
대상 데이터
Seven-week-old male Wistar rats (mean weight 252.5±9.90 g, DBL, Chungcheongbuk-do, South Korea) were used.
Table 1 summarizes the pharmacological composition of the DJT used in the present study. The materials were purchased from Okcheon-dong (Busan, Korea). The medicinal material was washed in an ultrasonic cleaner for 60 min and allowed to dry completely at room temperature before use.
이론/모형
The Kruskal–Wallis test and the Mann–Whitney U test were used to compare the groups.
성능/효과
In conclusion, DJT intravenous pharmacopuncture is likely to be effective for cisplatin-induced emesis and gastrointestinal mobility disorders. However, this study is limited to animals, and humanstudiesareneededbefore the clinicalapplications can be confirmed.
It is thought that DJT reduces gastrointestinal tract obstruction. The result of this study indicates that DJT intravenous pharmacopuncture may be effective in CINV.
후속연구
9). Further studies are needed to determine why this concentration is most effective, and research into the most effective concentration for humans should be conducted.
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