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NTIS 바로가기한국식품영양학회지 = The Korean journal of food and nutrition, v.30 no.4, 2017년, pp.673 - 680
김민섭 (원광대학교 생명과학부 기초자연과학연구소) , 정유헌 (원광대학교 생명과학부 기초자연과학연구소) , 오홍근 ((주)휴벳) , 박종군 (원광대학교 생명과학부 기초자연과학연구소)
Fludarabine, a chain terminating anti-cancer drug, is a purine analogue that causes DNA strand breaks in normal cells. In this study, we determined if A. melanocarpa and Korean red ginseng extract mixture reduce cytotoxicity of fludarabine. Treatment of HaCaT cells with
핵심어 | 질문 | 논문에서 추출한 답변 |
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아로니아는 어떤 성분들을 함유하고 있는가? | 아로니아(Aronia melanocarpa)는 장미과에 속하는 다년생 낙엽관목이며, 열매는 약용이나 식용으로 사용된다(ChungHJ 2014). 아로니아에는 안토시아닌을 비롯한 polyphenol, flavonoid, resveratrol, quercetin, 다양한 미네랄류를 함유하고 있다(Jeong 등 2016). 아로니아의 안토시아닌은 배당체의 형태로 존재하고 있으며, 항산화 효과, 혈당조절, 심혈관질환 저해 효과, 면적조절기능 등 만성질환 예방효과가 있다(Oszmianski& Wojdylo 2005; Chung HJ 2014; Kardum 등 2014; Park HM2014; Stanisavljević 등 2015; Park 등2017). | |
합성화학물질인 fludarabine은 어떤 방법으로 투여하는가? | 합성화학물질인 fludarabine은 1968년 생산된 물질로 강력한 알킬화제 물질이며, 림프성 백혈병에 효율적인 약물로서 사용되고 있다(Rai 등 2000). 또한 다른 약물들과 혼합하여 무통성 비 호킨즈 백혈병에 사용되고 있으며, 정맥주사 또는 구강을 통해 투여한다. Fludarabine은 퓨린 유사체로 DNA 중합효소와 상호작용하여 DNA 합성을 저해한다(Carbone 등 2001). | |
인삼의 효능은 무엇인가? | 홍삼은 보통 6년근의 좋은 인삼을 말려서 사용하는 것으로, 말리는 과정을 통해 인삼의 유효성분이 농축되고 보관 및 복용이 용이하여 인삼의 가공법으로 이용되어 왔다(Choi 등 2010; Jiménez 등2017). 또한 인삼은 면역증진, 항암, 항노화, 간 기능회복, 콜레스테롤 및 지방 감소 등의 효능이 보고되어 왔다(Kim 등 2005; Teng 등 2017; Yuan 등 2017). 그리고 인삼에 존재하는 사포닌류는 세포내에 p53의 수준을 높여 DNA 상해가 발생할 경우 빠른 회복에 도움을 준다(Ha 등 2010). |
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