최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기한국식품저장유통학회지 = Korean journal of food preservation, v.24 no.5, 2017년, pp.666 - 672
김기진 (계명대학교) , 정수련 (계명대학교) , 안나영 (계명대학교) , 박주식 (계명대학교) , 주영식 (계명대학교) , 김성욱 (계명대학교) , 이규호 (계명대학교) , 김미연 ((주)케이엠에프) , 정용진 ((주)케이엠에프)
The purpose of this study was to examine the effects of long-term endurance exercise and salvia miltiorrhiza vinegar on body composition and insulin resistance of high-fat diet (30% carbohydrate, 50% fat and 20% protein) induced obese rats. After 8 weeks of high fat diet (50% of total calories), rat...
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
제2형 당뇨병 치료제로써 합성 약물보다 천연물을 개발하기 위한 관심이 높아지는 이유는 무엇인가? | 따라서 제 2형 당뇨병 치료를 위한 다양한 방법들이 모색되어오고 있는데, 현재 sulfonylureas, non-sulfonylurea secretagogues, α-glucosidase inhibitors, thiazolidinedione, glucagon-like peptide-1 analog, dipeptidylpeptidase-4 inhibitors 등과 같은 약물이 주로 당뇨병 처치를 위한 약물로 사용되어오고 있다. 그러나 이러한 약물들은 부작용과 혈당 조절 실패율이 높게 나타나기 때문에(1,5) 그 대처방안이 요구되고 있다. 따라서 제 2형 당뇨병 치료제로써 합성 약물보다 독성이 적고 부작용이 적은 천연물을 개발하기 위한 관심이 점차적으로 높아지고 있다(6,7). | |
제 2형 당뇨병이란 무엇인가? | 제 2형 당뇨병은 인슐린 저항성(insulin resistance, IR)으로 인한 탄수화물, 단백질 및 지방 대사의 기능 저하를 특징으로 하는 대사성 질환으로서 당뇨병의 가장 흔한 유형이다(1,2). 지난 수십 년 동안 제 2형 당뇨병의 유병률은 전 세계적으로 현저히 증가하였으며, 부적절한 식습관과 신체활동으로 인해서 앞으로 더욱 증가 할 것으로 예상되고 있다(3,4). | |
제 2형 당뇨병 치료를 위한 치료법은 무엇인가? | 지난 수십 년 동안 제 2형 당뇨병의 유병률은 전 세계적으로 현저히 증가하였으며, 부적절한 식습관과 신체활동으로 인해서 앞으로 더욱 증가 할 것으로 예상되고 있다(3,4). 따라서 제 2형 당뇨병 치료를 위한 다양한 방법들이 모색되어오고 있는데, 현재 sulfonylureas, non-sulfonylurea secretagogues, α-glucosidase inhibitors, thiazolidinedione, glucagon-like peptide-1 analog, dipeptidylpeptidase-4 inhibitors 등과 같은 약물이 주로 당뇨병 처치를 위한 약물로 사용되어오고 있다. 그러나 이러한 약물들은 부작용과 혈당 조절 실패율이 높게 나타나기 때문에(1,5) 그 대처방안이 요구되고 있다. |
Tahrani AA, Piya MK, Kennedy A, Barnett AH (2010) Glycaemic control in type 2 diabetes: Targets and new therapies. Pharmacol Ther, 125, 328-361
Nolan CJ, Ruderman NB, Kahn SE, Pedersen O, Prentki M (2015) Insulin resistance as a physiological defense against metabolic stress: Implications for the management of subsets of type 2 diabetes. Diabetes, 64, 673-686
Shaw JE, Sicree RA, Zimmet PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 87, 4-14
Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Zhou Z, Shan G, He J (2010) Prevalence of diabetes among men and women in China. N Engl J Med, 362, 1090-1101
Tahrani AA, Barnett AH, Bailey CJ (2016) Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol, 12, 566-592
Prabhakar PK, Doble M (2008) A target based therapeutic approach towards diabetes mellitus using medicinal plants. Curr Diabetes Rev, 4, 291-308
Xu X, Liang T, Lin X, Wen Q, Liang X, Li W, Qin F, Zheng N, Ming J, Huang R (2015) Effect of the total extract of averrhoacarambola (oxalidaceae) root on the expression levels of TLR-4 and NF-kB in streptozotocininduced diabetic mice. Cell Physiol Biochem, 36, 2307-2316
Shon YH, Cho HJ, Kim MK, Jung EJ, Nam KS (2007) Effect of ethanol extract from Salvia miltiorrhiza on chemoprevention and metastasis of breast cancer. Kor J Pharmacogn, 38, 62-66
Ji XY, Tan BKH, Zhu YZ (2000) Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol Sin, 21, 1089-1094
Ng CF, Koon CM, Cheung DWS, Lam MY, Leung PC, Lau CBS, Fung KP (2011) The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation. J Ethnopharmacol, 137, 1366-1372
Pan C, Huo Y, An X, Singh G, Chen M, Yang Z, Pu J, Li J (2012) Panax notoginseng and its components decreased hypertension via stimulation of endothelialdependent vessel dilatation. Vasc Pharmacol, 56, 150-158
Wing-Shing Cheung D, Koon CM, Ng CF, Leung PC, Fung KP, Kar-Sing Poon S, Bik-San Lau C (2012) The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: a study of the combination effects of the 2-herb formula. J Ethnopharmacol, 143, 859-866
Cheng GC, Lee JY, Kim DC, Suh SO, Hwang WI (2000) Inhibitory effect of Salvia miltiorrhiza extract on growth of some cancer cells. J Korean Soc Food Sci Nutr, 29, 726-731
Cao W, Guo XW, Zheng HZ, Li DP, Jia GB, Wang J (2012) Current progress of research on pharmacologic actions of salvianolic acid B. Chin J Integr Med, 18, 316-320
Lin C, Liu Z, Lu Y, Yao Y, Zhang Y, Ma Z, Kuai M, Sun X, Sun S, Jing Y, Yu L, Li Y, Zhang Q, Bian H (2016) Cardioprotective effect of salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis. J Pharm Pharmacol, 68, 941-952
Lv H, Wang L, Shen J, Hao S, Ming A, Wang X, Su F, Zhang Z (2015) Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. Brain Res Bull, 115, 30-36
Huang M, Xie Y, Chen L, Chu K, Wu S, Lu J, Chen X, Wang Y, Lai X (2012) Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats. Phytother Res, 26, 944-948
Wang P, Xu S, Li W, Wang F, Yang Z, Jiang L, Wang Q, Huang M, Zhou P (2014) Salvianolic acid B inhibited $PPAR{\gamma}$ expression and attenuated weight gain in mice with high-fat diet-induced obesity. Cell Physiol Biochem, 34, 288-298
Huang M, Wang P, Xu S, Xu W, Xu W, Chu K, Lu J (2015) Biological activities of salvianolic acid B from Salvia miltiorrhiza on type 2 diabetes induced by high-fat diet and streptozotocin. Pharm Biol, 53, 1058-1065
Raoufi S, Baluchnejadmojarad T, Roghani M, Ghazanfari T, Khojasteh F, Mansouri M (2015) Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocininduced diabetes. Pharm Biol, 53, 1803-1809
Yamashita H, Fujisawa K, Ito E, Idei S, Kawaguchi N, Kimoto M, Hiemori M, Tsuji H (2007) Improvement of obesity and glucose tolerance by acetate in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biosci Biotechnol Biochem, 71, 1236-1243
Hancock CR, Han DH, Chen M, Terada S, Yasuda T, Wright DC, Holloszy JO (2008) High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc Natl Acad Sci USA, 105, 7815-7820
Lee JH, Cho HD, Jeong JH, Lee MK, Jeong YK, Shim KH, Seo KI (2013) New vinegar produced by tomato suppresses adipocyte differentiation and fat accumulation in 3T3-L1 cells and obese rat model. Food Chem, 141, 3241-3249
Ivy JL, Young JC, McLane JA, Fell RD, Holloszy JO (1983) Exercise training and glucose uptake by skeletal muscle in rats. J Appl Physiol, 55, 1393-1396
Chapados N, Collin P, Imbeault P, Corriveau P, Lavoie JM (2008) Exercise training decreases in vitro stimulated lipolysis in a visceral (mesenteric) but not in the retroperitoneal fat depot of high-fat-fed rats. Br J Nutr, 100, 518-525
Votruba SB, Jensen MD (2007) Regional fat deposition as a factor in FFA metabolism. Ann Rev Nutr, 27, 149- 163
Brighenti F, Castellani G, Benini L, Casiraghi MC, Leopardi E, Crovetti R, Testolin G (1995) Effect of neutralized and native vinegar on blood glucose and acetate responses to a mixed meal in healthy subjects. Eur J Clin Nutr, 49, 242-247
Ebihara K, Nakajima A (1998) Effect of acetic acid and vinegar on blood glucose and insulin responses to orally administered sucrose and starch. Agric Biol Chem, 52, 1311-1322
Liljeberg H, Bjorck I (1998) Delayed gastric emptying rate may explain improved glycaemia in healthy subjects to a starchy meal with added vinegar. Eur J Clin Nutr, 52, 368-371
Ogawa N, Satsu H, Watanabe H, Fukaya M, Tsukamoto Y, Miyamoto Y, Shimizu M (2000) Acetic acid suppresses the increase in disaccharidase activity that occurs during culture of Caco-2 cells. J Nutr, 130, 507-513
Fushimi T, Sato Y (2005) Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats. Br J Nutr, 94, 714-719
Qiang G, Yang X, Shi L, Zhang H, Chen B, Zhao Y, Zu M, Zhou D, Guo J, Yang H, Zhang L, Du G (2015) Antidiabetic effect of salvianolic acid a on diabetic animal models via AMPK activation and mitochondrial regulation. Cell Physiol Biochem, 36, 395-408
Xie P, Duan Y, Guo X, Hu L, Yu M (2015) SalA attenuates hypoxia-induced endothelial endoplasmic reticulum stress and apoptosis via down-regulation of VLDL receptor expression. Cell Physiol Biochem, 35, 17-28
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.