흰점박이꽃무지 유충 추출물이 Co-60 감마선에 조사된 수컷 흰쥐의 혈구 및 전립선에 미치는 방사선 방호효과 Radiation Protection Effect of Protaetia Brevitarsis Larvae Extracts on Blood and Prostate in Male Rats Irradiated with Co-60 Gamma-ray원문보기
This study is desinged to examine for radiation protection effect of Protaetia Brevitarsis Larvae extracts on the blood and prostate of male rat as a natural radiation protection agent. 5 groups were classified using 90 male rat as experimental animals. Each group was clssified as normal control gro...
This study is desinged to examine for radiation protection effect of Protaetia Brevitarsis Larvae extracts on the blood and prostate of male rat as a natural radiation protection agent. 5 groups were classified using 90 male rat as experimental animals. Each group was clssified as normal control group (NC Group), the group administered protaetia brevitarsis larvae extracts (PBE Group), irradiated group (IR Group), irradiated group after administration of protaetia brevitarsis larvae extracts (PBE+IR Group), the group administered protaetia brevitarsis larvae extracts after irradiaton (IR+PBE Group). In IR Group, 7 Gy/h of Co-60 gamma ray was irradiated to SD rats. In PBE+IR Group, protaetia brevitarsis larvae extacts wewe injected at 200 mg/kg/day for 14 days before irradiation, In IR+PBE Group, protaetia brevitarsis larvae extract was injeted after irradiation. On the 1, 7 and 21 days after irradiation, the experimental animals were sacrificed to evaluate the changes in blood cell component, superoxide dismutase (SOD) activity, histopathological evaluation of the liver and prostate gland. As a result, the PBE+IR Group and IR+PBE Group showed a significantly recovery of white blood cell (p<0.01, p<0.01), platelet (p<0.01, p<0.01) than the IR Group. It was also confirmed that SOD activity of PBE+IR Group (p<0.01) and IR+PBE Group (p<0.01) was significantly increased than the IR Group. Also PBE+IR Group and IR+PBE Group showed less inflammatory reactions of cystoplasm in the prostate gland than the IR Group. In conclusion, the protaetia brevitarsis larvae have radioprotection effect against blood and prostate gland. It is expected to be useful for research of radiation protection agent.
This study is desinged to examine for radiation protection effect of Protaetia Brevitarsis Larvae extracts on the blood and prostate of male rat as a natural radiation protection agent. 5 groups were classified using 90 male rat as experimental animals. Each group was clssified as normal control group (NC Group), the group administered protaetia brevitarsis larvae extracts (PBE Group), irradiated group (IR Group), irradiated group after administration of protaetia brevitarsis larvae extracts (PBE+IR Group), the group administered protaetia brevitarsis larvae extracts after irradiaton (IR+PBE Group). In IR Group, 7 Gy/h of Co-60 gamma ray was irradiated to SD rats. In PBE+IR Group, protaetia brevitarsis larvae extacts wewe injected at 200 mg/kg/day for 14 days before irradiation, In IR+PBE Group, protaetia brevitarsis larvae extract was injeted after irradiation. On the 1, 7 and 21 days after irradiation, the experimental animals were sacrificed to evaluate the changes in blood cell component, superoxide dismutase (SOD) activity, histopathological evaluation of the liver and prostate gland. As a result, the PBE+IR Group and IR+PBE Group showed a significantly recovery of white blood cell (p<0.01, p<0.01), platelet (p<0.01, p<0.01) than the IR Group. It was also confirmed that SOD activity of PBE+IR Group (p<0.01) and IR+PBE Group (p<0.01) was significantly increased than the IR Group. Also PBE+IR Group and IR+PBE Group showed less inflammatory reactions of cystoplasm in the prostate gland than the IR Group. In conclusion, the protaetia brevitarsis larvae have radioprotection effect against blood and prostate gland. It is expected to be useful for research of radiation protection agent.
Choi HS, Choi JH, Jung DY, Kim JO, Shin JH, Kim JH, Min BI. Radiation protection effect of selenium on the rat's prostate. Journal of Radiological Science and Technology. 2017;40(2):317-322.
Jung DY, Choi HS, Kim JO, Shin JH, Kim JH, Park GJ, Min BI. Radiation protective effect of selenium and folic acid mixtures in the development of congenital anomalies following radiation exposure to the fetus of perinatal female white rats. Journal of Radiological Science and Technology. 2018;41(2):157-162.
Kim JO, Choi JH, Shin JH, Jung DY, Min BI. The effects of cynanchi wilfordii radix ethanol extracts upon irradiated rat's blood and organ. Journal of Radiological Science and Technology. 2016;39(3):451-459.
Chung IY, Koh JH, Chung HW, Chil SY, Yoo SY, Koh KH. An experimental study on radioprotective effect of DDC, MEA, and WR-2721. Journal of Radiation Protection and Research. 1986;11(2):114-122.
Jang SI, Lee JH. Radioprotective effects of blueberry on the liver of radiation irradiated rats. Journal of the Korean Society of Radiology. 2013;7(3):239-244.
Lee HS, Ryu HJ, Song HJ, Lee SO. Enzymatic preparation and antioxidant activities of protein hydrolysates from protaetia brevitarsis larvae. Journal of the Korean Society of Food Science and Nutrition. 2017;46(10):1164-1170.
Singer P, Jaeger W, Berger I. Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. Journal of Human Hypertension. 1990;4(3):227-233.
Om AS, Chung KW. Dietary zinc deficiencyalters 5α-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. The Journal of Nutrition. 1996;126(4):842-848.
Natali F, Siculella L, Salvati S, Gnoni GV. Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells. Journal of Lipid Research. 2007;48(9):1966-1975.
Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry. 1974;47(3):469-474.
Petkau A. Role of superoxide dismutase in modification of radiation injury. Br J Cancer Suppl. 1987;8:87-95.
Kang IJ, Kim HK, Chung CK, Kim SJ, Oh DH. Effects of Protaetia Orientalis (Gory et Perchlon) larva on the lipid metabolism in ethanol administered rats. Journal of the Korean Society of Food Science and Nutrition. 2000;29(3):479-484.
Chon JW, Kweon HY, Jo YY, Yeo JH, Lee HS. Protective effects of extracts of protaetia brevitarsis on carbon tetrachloride-induced hepatotoxicity in the mice. J Seric Entomol Sci. 2012;50(2): 93-100.
AI-Helper
※ AI-Helper는 부적절한 답변을 할 수 있습니다.