[논문]동신기혈양수방(東新氣血養睡方) 액상 스틱 파우치가 Chronic Mild Stress 유발 흰쥐의 스트레스 및 수면 관련 호르몬에 미치는 영향

최창원; 이영수; 문영호; 김경옥

doi:10.7231/jon.2017.28.3.231

[국내논문] 동신기혈양수방(東新氣血養睡方) 액상 스틱 파우치가 Chronic Mild Stress 유발 흰쥐의 스트레스 및 수면 관련 호르몬에 미치는 영향
The Effects Liquid Stick Packs of Dongshingihyeolyangsubang on Stress and Sleep-Related Substance of Rats Induced by Chronic Mild Stress 원문보기

동의신경정신과학회지 = Journal of oriental neuropsychiatry, v.28 no.3, 2017년, pp.231 - 248

최창원 (동신대학교 한의과대학 내과학교실) , 이영수 (동신대학교 한의과대학 내과학교실) , 문영호 (동신대학교 한의과대학 내과학교실) , 김경옥 (동신대학교 한의과대학 한방신경정신과학교실)

Abstract ▼ AI-Helper

Objectives: This study evaluates anti-stress and sleep-inductive effects of Dongshingihyeolyangsubang (DSGYSB) on rats induced by chronic mild stress (CMS). Methods: Twenty-five healthy rats were randomly divided into five groups: normal, CMS (Control), DSGYSB50, DSGYSB100, and DSGYSBS200. All rats except the normal group were exposed to unpredictable stress conditions such as water deprivation, empty bottles, and forced treadmill. A week after starting the experiment, rats in DSGYSB50, DSGYSB100, and DSGYSB200 groups were fed orally with water once a day for two weeks. Then blood samples were taken from the rats for analysis of complete blood count, AST, ALT, and glucose. Noradrenaline, corticosterone, serotonin, GABA and melatonin were measured by ELISA kit. BDNF, CREB, TrkB and $TNF-{\alpha}$ were measured by RT-PCT. Results: In Noradrenaline contents, the DSGYSB200 group revealed significant decrease compared to the control group. In corticosterone contents, the DSGYSB200 group revealed significant decrease compared to the control group. In serotonin contents, the DSGYSB200 group revealed significant increase compared to the control group. In GABA contents, the DSGYSB50, DSGYSB100, and DSGYSB200 groups revealed significant increase compared to the control group. In the activity of BDNF, the DSGYSB50, DSGYSB100 and DSGYSB200 groups revealed significant increase compared to the control group. In the activity of CREB, the DSGYSB100 and DSGYSB200 groups revealed a significant decrease compared to the control group. In the activity of TrkB, the DSGYSB100 and DSGYSB200 groups revealed significant decrease compared to the control group. In the activity of $TNF-{\alpha}$, DSGYSB100 and DSGYSB200 groups revealed significant decrease compared to the control group. In glucose contents, the DSGYSB100 and DSGYSB200 groups revealed significant decrease compared to the control group. In the leukocyte changes, white blood cells, neutrophil, lymphocytes, and monocyte significantly increased in the DSGYSB100 and DSGYSB200 groups than the control group. In the erythrocyte changes, hemoglobin significantly increased in the DSGYSB200 group than the control group. Conclusions: Results suggest that Dongshingihyeolyangsubang has anti-stress and sleep-inductive effects on rats induced by CMS.

Keyword

질의응답

핵심어	질문	논문에서 추출한 답변
	수면은 인간에게 어떤 요소인가?	수면은 신체적ㆍ정신적 성장과 안정 및 두뇌의 발달에 기초적인 생리적 현상으로 인간이 정상적인 활동을 영위하는데 필수적인 요소이다1). 이러한 수면이 시작이나 유지가 어려워 충분한 수면을 취하지 못하거나 불충분한 수면으로 피로감, 무력감 및 주의 집중력 감소 등이 동반하는 것을 수면장애라고 한다2).
	수면장애는 무엇인가?	수면은 신체적ㆍ정신적 성장과 안정 및 두뇌의 발달에 기초적인 생리적 현상으로 인간이 정상적인 활동을 영위하는데 필수적인 요소이다1). 이러한 수면이 시작이나 유지가 어려워 충분한 수면을 취하지 못하거나 불충분한 수면으로 피로감, 무력감 및 주의 집중력 감소 등이 동반하는 것을 수면장애라고 한다2). 이러한 수면장애는 크게 4가지의 범주가 있는데, 그 중 하나가 스트레스나 입원과 같은 환경적 변화로 생길 수 있다고 한다1).
	한의학에서 수면장애에 처방하는 동신기혈양수방에 대해 설명하시오.	본 연구에서 사용된 동신기혈양수방은 ≪변증기문(辨證奇聞)≫9)의 <불매문(不寐門)>에 수록된 윤조교심탕(潤燥交心湯)에 수증가감(隨證加減)한 것으로 저자의 임상에서 심신불교(心腎不交)하고 간기태조(肝氣太燥)하여 생기는 불면과, 막연한 불안이나 생각이 많아 쉽게 잠을 이루지 못하는 경우와 오래도록 근심걱정을 한 후에 피곤하지만 잠을 이루지 못하는 경우 등 다양하게 활용하고 있는 처방이다.

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