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NTIS 바로가기한국산업보건학회지 = Journal of Korean Society of Occupational and Environmental Hygiene, v.27 no.3, 2017년, pp.193 - 200
손영우 (원광대학교 의과대학 산본병원) , 임요섭 (순천대학교 생명산업과학대학) , 서영미 (서남대학교 간호학과)
Objectives: This study was performed to evaluate the neurototoxicity of the environmental pollutant lead acetate(LA) and the protective effect of the D-2-amino-5-phosphonovaleric acid(APV), N-methyl-D-aspartate(NMDA) receptor antagonist on LA-induced cytotoxicity in cultured C6 glioma cells. Materia...
핵심어 | 질문 | 논문에서 추출한 답변 |
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납중독의 임상적 징후는 무엇인가? | ,1994). 납중독에 대한 임상적 징후로는 피로나 기억감퇴를 비롯하여 위장장애, 정신적 조증(mania) 및 반사소실 등과 같은 현상을 나타냄으로써 조기진찰과 빠른 진단을 통해 치료하지 않으면 심각한 후유증을 초래한다(Busselberg, 1991). 뇌조직 중 신경교세포(neuroglial cell)는 납중독 시 가장 빠르게 활성화되어 손상된 뇌의 회복을 위하여 가장 먼저 반응하는 일차적인 반응세포이다(Chen et al. | |
자유라디칼의 특징은 무엇인가? | , 2014). 산화적 손상을 유발하는 자유라디칼은 막의 지질과산화사슬(lipid peroxidation channel)을 촉진시킬 뿐만 아니라(Hah et al., 2005), 칼슘채널과 연관되어 막표면에 위치하고 있는 N-methyl-D-aspatate(NMDA) 수용체를 과활성 시켜 세포내로 다량의 칼슘이 유입되어 세포의 퇴화나 사멸을 초래한다(Jung, 2009). 세포내로 유입된 칼슘은 calcium-mediated intercellular free radicals를 생성하여 세포고사를 더욱 촉진시킨다(Pellegrini-Giampietro et al. | |
납독성이 인체에 과량 축적될 경우 어떤 일이 발생되는가? | , 2014). 그러나 독성이 강하기 때문에 일단 인체 내 과량이 축적된 경우, 납중독을 유발함으로써 심각한 부작용을 초래하게 된다(Son & Jung, 2012). 특히, 납은 피부접촉이나 호흡기를 통하여 인체 내로 유입된 후 혈류를 통해 조혈기능에 손상을 줄 뿐 아니라, 혈액-뇌장벽(blood-brain barrier, BBB)을 통과하여 뇌중독을 유발한다는 것은 이미 잘 알려진 사실이다(Bressler et al.,1994). |
Bakker MH, Mckernan RM, Wong EM, Foster AC. [ $^{3}H$ ] MK-801 binding to N-methyl-D-aspartate receptors sloubilized from rat brain: Effects of glycine site ligands, polyamines, ifenprodil, and desipramine. J Neurochem 1991;57:39-45
Borenfreund E, Puerner JA. A simple quantitative procedure using monolayer culture for cytotoxicity assay (HTD/NR-90). J Tiss Cult Meth 1984;9(1):7-9
Bressler J, Forman S, Goldstein GW. Phospholipid metabolism in neural microvascular endothelial cells after exposure to lead in vitro. Toxicol Appl Pharmacol 1994;126:352-360
Buchan A, Gertler SZ, Li H, Xue ZG, Chaundy KE. A selective N-type $Ca^{2+}$ channel blocker prevent CA1 injury 24 hr following severe forebrain ischemia and reduces in fraction following focal ischemia. J Cereb Blood Flow Metab 1994;14:903-910
Busselberg D, Evans ML, Rahmann H, Carpenter DO. Lead and zinc block a voltage-activated calcium channel of aplysia neurons. J Neurophysiol 1991;65:786-795
Busselberg D, Evans ML, Haas HL, Carpenter DO. Blockade of mammalian and invertebrate calcium channels by lead. Neurotoxicol 1993;14:249-258
Chen YJ, Yang BC, Hsieh WC, Huang BM, Liu MY. Enhancement of $TNF-{\alpha}$ expression does not trigger apoptosis upon exposure of glial cells to lead and lipopolysaccharide. Toxicol 2002;178:183-191
Choi YS, Ha DH, Jeong SJ, Lee JH, Kim SS, et al. Effects of acanthopancis cortex on osteo- blasts damaged by $FeSO_4$ . Kor J Med Physiol Pathol 2001;15(4):581-584
Ha DH, Yang HW, Lee JH, Lee KC. Effect of NMDA receptor antagonist on osteoblasts damaged by methymercuric chloride. Kor J Oriental Physiol Pathol 2003;17(2):412-415
Hah DS, Kim CH, Kim GS, Kim EG, Kim JS. Antioxidative effects of traditional medicinal plants on lipid peroxidation, Kor J Ver Res 2005;45(3):341-350
Han DH, Kwon KB, Kim WK, Oh KS, Kim IG, et al. Effects of Sylso-san water extract on LDH activity in cultured myocardial cells. Kor J Oriental Med Physiol & Pathol 2001;15(5):770-774
Jung IJ. The effect of NMDA/glycin receptor antagonist, 7-chlorokynurenic acid on cultured astrocytes damaged by ischemia-like condition. Kor J Biomed Labor Sci 2009;15(4):355-362
Jung JY, Oh YH, Park SH, Yoon MY, Pyo AJ, et al. Antioxidative and whitening effects Houttuynia cordata extract on lead acetate of hair dye component. J Invest Cosm 2014;10(2):99-105
Kern M, Audesirk T, Audesirk G. Effects of inorganic lead on the differentiation and growth of cortical neurons in culture. Neurotoxical 1993;14:319-327
Kikuchi S, Kim SU. Glutamate neurotoxicity in mesencephalic dopaminergic neurons in culture. J Neurosci Res 1993;36:558-569
Kim SJ, Yu YW, Lee JK. Cytotoxicity and protective effect of Portulaca oleracea L. extract on cultured neuroglioma cells damaged by aluminum of dementiainduced agent. J Kor Soc Plants Environ 2013;16(5):251-256
Leonard S, Wang S, Zang L, Castranova V, Vallyathan V, et al. Role of molecular oxygen in the generation of hydroxyl and super- oxide anion radicals during enzymatic Cr (VI)- induced carcinogenesis. J Environ Pathol Toxicol Oncol 2000;19(1-2):49-60
Lim KT, Park ST, Cho MK, Chung YT. Neuronal cytotoxicity of oxygen radical in newborn mouse forebrain culture. Kor J Toxicol 1995;11(2):187-192
Liu Y, Hsieh WC, Yang BC. In vitro aberrant gene expression as the indicator of lead-induced neurotoxicity in U-373MG cells. Toxicol 2000;147(1):59-64
Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods 1983;65(1-2):55-63
Park ST, Lim KT, Chung YT, Kim SU. Methylmercuryinduced neurotoxicity in cerebral neuron culture is blocked by antioxidants and NMDA receptor antagonists. Neurotoxicol 1996;17(1):37-46
Pellegrini-Giampietro DE, Cheriei G, Alesiani M, Carla V, Moroni F. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemiainduced neuronal damage. J Neurosci 1990;10:1035-1041
Son YW, Jung IJ. Alleviating effect of Elscholtziae splendense extract on the induced toxicity by lead actate of hair dye compound in cultured glioma cells. J Invest Cosm 2012;8(2):115-120
Tiffany CE, Garcia DE, Wu JN, Zmudzki J, Brattpn GR. Effects of lead on viability and intercellular metal content of C6 glioma cells. J Toxicol Environ Health 1988;23:267-279
Zeman S, Lloyd C, Meldrum B, Leigh PN. Excitatory amino acid, free radicals and the pathogenesis of motor neuron disease. Neuro Appl Neurobiol 1994;20:219-231
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