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한국산업보건학회지 = Journal of Korean Society of Occupational and Environmental Hygiene, v.27 no.3, 2017년, pp.193 - 200
손영우 (원광대학교 의과대학 산본병원) , 임요섭 (순천대학교 생명산업과학대학) , 서영미 (서남대학교 간호학과)
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Objectives: This study was performed to evaluate the neurototoxicity of the environmental pollutant lead acetate(LA) and the protective effect of the D-2-amino-5-phosphonovaleric acid(APV), N-methyl-D-aspartate(NMDA) receptor antagonist on LA-induced cytotoxicity in cultured C6 glioma cells. Materia...
| 핵심어 | 질문 | 논문에서 추출한 답변 |
|---|---|---|
| 납중독의 임상적 징후는 무엇인가? | ,1994). 납중독에 대한 임상적 징후로는 피로나 기억감퇴를 비롯하여 위장장애, 정신적 조증(mania) 및 반사소실 등과 같은 현상을 나타냄으로써 조기진찰과 빠른 진단을 통해 치료하지 않으면 심각한 후유증을 초래한다(Busselberg, 1991). 뇌조직 중 신경교세포(neuroglial cell)는 납중독 시 가장 빠르게 활성화되어 손상된 뇌의 회복을 위하여 가장 먼저 반응하는 일차적인 반응세포이다(Chen et al. | |
| 자유라디칼의 특징은 무엇인가? | , 2014). 산화적 손상을 유발하는 자유라디칼은 막의 지질과산화사슬(lipid peroxidation channel)을 촉진시킬 뿐만 아니라(Hah et al., 2005), 칼슘채널과 연관되어 막표면에 위치하고 있는 N-methyl-D-aspatate(NMDA) 수용체를 과활성 시켜 세포내로 다량의 칼슘이 유입되어 세포의 퇴화나 사멸을 초래한다(Jung, 2009). 세포내로 유입된 칼슘은 calcium-mediated intercellular free radicals를 생성하여 세포고사를 더욱 촉진시킨다(Pellegrini-Giampietro et al. | |
| 납독성이 인체에 과량 축적될 경우 어떤 일이 발생되는가? | , 2014). 그러나 독성이 강하기 때문에 일단 인체 내 과량이 축적된 경우, 납중독을 유발함으로써 심각한 부작용을 초래하게 된다(Son & Jung, 2012). 특히, 납은 피부접촉이나 호흡기를 통하여 인체 내로 유입된 후 혈류를 통해 조혈기능에 손상을 줄 뿐 아니라, 혈액-뇌장벽(blood-brain barrier, BBB)을 통과하여 뇌중독을 유발한다는 것은 이미 잘 알려진 사실이다(Bressler et al.,1994). |
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