$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

아시아인종에서 만성골수성백혈병과 Glutathione S-transferase 유전자 다형성의 메타분석
Association between the Polymorphism of Glutathione S-transferase Genes and Chronic Myeloid Leukemia in Asian Population: a Meta-analysis 원문보기

한국콘텐츠학회논문지 = The Journal of the Korea Contents Association, v.17 no.10, 2017년, pp.289 - 299  

김희성 (단국대학교 의과대학 제일병원 진단검사의학과)

초록
AI-Helper 아이콘AI-Helper

아시아인종에서 만성골수성백혈병 (Chronic myeloid leukemia; CML)과 Glutathione S-transferase(GST) 유전자 다형성과 관련된 감수성을 검증하기 위해, 2017년 7월까지 발표된 9편의 논문들을 메타분석에 인용하였다. GST 유전자 다형성의 아형 중 M1 (GSTM1)과 T1 (GSTT1)의 유전자의 null, present 유형을 개별적으로 분석하였다. CML환자와 GST 유전자 다형성 사이에 연관성이 발견되었다.(GSTM1; OR=1.306, 95% CI=1.091-1.563, p=0.004, GSTT1; OR=1.987, 95% CI=1.438-2.746, p=0.000). 또한, CML 환자와 GSTM1-GSTT1 유전자 다형성 조합 null 유형의 연관성이 있었다(OR=4.191, 95% CI=2.833-6.201, p=0.000). 이와 같이, 아시아인종에서 GSTM1 유전자 다형성, GSTT1 유전자 다형성, GSTM1-GSTT1 유전자 다형성 조합은 CML 환자의 위험인자가 될 수 있다.

Abstract AI-Helper 아이콘AI-Helper

To verify the association between susceptibility to chronic myeloid leukemia (CML) and GSTM1, GSTT1 gene polymorphisms in Asian populations, 9 papers published until July 2017 were cited in a meta-analysis. The null present types of the GSTM1, GSTT1 gene were analyzed individually. The significant a...

주제어

표/그림 (4)

참고문헌 (50)

  1. E. Estey and H. Dohner, "Acute myeloid leukaemia," Lancet, Vol.368, No.9550, pp.1894-1907, 2006. 

  2. J. D. Hayes, J. U. Flanagan, and I. R. Jowsey, "Glutathione transferases," Annu Rev Pharmacol Toxicol, Vol.45, pp.51-88, 2005. 

  3. A. Hatagima, "Genetic polymorphisms and metabolism of endocrine disruptors in cancer susceptibility," Cad Saude Publica, Vol.18, No.2, pp.357-377, 2002. 

  4. D. A. Arber, A. Orazi, R. Hasserjian, J. Thiele, M. J. Borowitz, M. M. Le Beau, C. D. Bloomfield, M. Cazzola, and J. W. Vardiman, "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia," Blood, Vol.127, No.20, pp.2391-2405, 2016. 

  5. E. Jabbour and H. Kantarjian, "Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management," Am J Hematol, Vol.89, No.5, pp.547-556, 2014. 

  6. S. O'Brien, J. P. Radich, C. N. Abboud, M. Akhtari, J. K. Altman, E. Berman, P. Curtin, D. J. DeAngelo, M. Deininger, S. Devine, A. T. Fathi, J. Gotlib, M. Jagasia, P. Kropf, J. O. Moore, A. Pallera, V. V. Reddy, N. P. Shah, B. D. Smith, D. S. Snyder, M. Wetzler, K. Gregory, and H. Sundar, "Chronic myelogenous leukemia, version 1.2015," J Natl Compr Canc Netw, Vol.12, No.11, pp.1590-1610, 2014. 

  7. M. W. Deininger, J. M. Goldman, and J. V. Melo, "The molecular biology of chronic myeloid leukemia," Blood, Vol.96, No.10, pp.3343-3356, 2000. 

  8. J. Bjork, M. Albin, H. Welinder, H. Tinnerberg, N. Mauritzson, T. Kauppinen, U. Stromberg, B. Johansson, R. Billstrom, Z. Mikoczy, T. Ahlgren, P. G. Nilsson, F. Mitelman, and L. Hagmar, "Are occupational, hobby, or lifestyle exposures associated with Philadelphia chromosome positive chronic myeloid leukaemia?," Occup Environ Med, Vol.58, No.11, pp.722-727, 2001. 

  9. P. D. Josephy, "Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology," Human genomics and proteomics : HGP, Vol.2010, p.876940, 2010. 

  10. P. J. Jakobsson, S. Thoren, R. Morgenstern and B. Samuelsson, "Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target," Proceedings of the National Academy of Sciences of the United States of America, Vol.96, pp.7220-7225, 1999. 

  11. D. M. Townsend, K. D. Tew, and H. Tapiero, "The importance of glutathione in human disease," Biomedicine & pharmacotherapy Biomedecine & pharmacotherapie, Vol.57, pp.145-155, 2003. 

  12. P. Jemth, G. Stenberg, G. Chaga and B. Mannervik, "Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2," The Biochemical journal, Vol.316(Pt 1), pp.131-136, 1996. 

  13. A. M. Ghelani, A. Samanta, A. C. Jones, and S. S. Mastana, "Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom," Rheumatology international, Vol.31, pp.1355-1361, 2011. 

  14. B. T. Ashok and R. Ali, "Binding of human anti-DNA autoantibodies to reactive oxygen species modified-DNA and probing oxidative DNA damage in cancer using monoclonal antibody," International journal of cancer. Journal international du cancer, Vol.78, pp.404-409, 1998. 

  15. B. T. Ashok and R. Ali, "The aging paradox: free radical theory of aging," Experimental gerontology, Vol.34, pp.293-303, 1999. 

  16. B. Ardesjo, C. M. Hansson, C. E. Bruder, F. Rorsman, C. Betterle, J. P. Dumanski, O. Kampe, and O. Ekwall, "Autoantibodies to glutathione S-transferase theta 1 in patients with primary sclerosing cholangitis and other autoimmune diseases," Journal of Autoimmunity, Vol.30, pp.273-282, 2008. 

  17. C. Duggan, R. Ballard-Barbash, R. N. Baumgartner, K. B. Baumgartner, L. Bernstein, and A. McTiernan, "Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile(105)Val polymorphism, and mortality in breast cancer survivors," Springerplus, Vol.2, p.450, 2013. 

  18. W. Tan, N. Song, G. Q. Wang, Q. Liu, H. J. Tang, F. F. Kadlubar, and D. X. Lin, "Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China," Cancer Epidemiol Biomarkers Prev, Vol.9, No.6, pp.551-556, 2000. 

  19. H. R. He, X. X. Zhang, J. Y. Sun, S. S. Hu, Y. Ma, Y. L. Dong, and J. Lu, "Glutathione S-transferase gene polymorphisms and susceptibility to chronic myeloid leukemia," Tumour Biol, Vol.35, No.6, pp.6119-6125, 2014. 

  20. M. Karkucak, T. Yakut, T. Gulten, and R. Ali, "Investigation of GSTP1 (Ile105V al) Gene Polymorphism in Chronic Myeloid Leukaemia Patients," Int J Hum Genet, Vol.12, No.3, pp.145-149, 2012. 

  21. A. Hishida, S. Terakura, N. Emi, K. Yamamoto, M. Murata, K. Nishio, Y. Sekido, T. Niwa, N. Hamajima, and T. Naoe, "GSTT1 and GSTM1 deletions, NQO1 C609T polymorphism and risk of chronic myelogenous leukemia in Japanese," Asian Pac J Cancer Prev, Vol.6, No.3, pp.251-255, 2005. 

  22. B. C. Mondal, N. Paria, S. Majumdar, S. Chandra, A. Mukhopadhyay, U. Chaudhuri, and U. B. Dasgupta, "Glutathione S-transferase M1 and T1 null genotype frequency in chronic myeloid leukaemia," Eur J Cancer Prev, Vol.14, No.3, pp.281-284, 2005. 

  23. A. Hirvonen, "Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer," Environ Health Perspect, Vol.107, Suppl.1, pp.37-47, 1999. 

  24. P. Bajpai, A. K. Tripathi, and D. Agrawal, "Increased frequencies of glutathione-S-transferase (GSTM1 and GSTT1) null genotypes in Indian patients with chronic myeloid leukemia," Leuk Res, Vol.31, No.10, pp.1359-1363, 2007. 

  25. E. Zintzaras and J. Lau, "Trends in meta-analysis of genetic association studies," J Hum Genet, Vol.53, No.1, pp.1-9, 2008. 

  26. E. Zintzaras, "C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies," Psychiatr Genet, Vol.16, No.3, pp.105-115, 2006. 

  27. H. C. Chen, W. X. Hu, Q. X. Liu, W. K. Li, F. Z. Chen, Z. Z. Rao, X. F. Liu, Y. P. Luo, and Y. F. Cao, "Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility," Eur J Cancer Prev, Vol.17, No.3, pp.251-258, 2008. 

  28. M. Taspinar, S. E. Aydos, O. Comez, A. H. Elhan, H. G. Karabulut, and A. Sunguroglu, "CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia," Swiss Med Wkly, Vol.138, No.1-2, pp.12-17, 2008. 

  29. G. Bhat, A. Bhat, A. Wani, N. Sadiq, S. Jeelani, R. Kaur, A. Masood, and B. Ganai, "Polymorphic variation in glutathione-S-transferase genes and risk of chronic myeloid leukaemia in the Kashmiri population," Asian Pac J Cancer Prev, Vol.13, No.1, pp.69-73, 2012. 

  30. N. Ozten, A. Sunguroglu, and M. C. Bosland, "Variations in glutathione-S-transferase genes influence risk of chronic myeloid leukemia," Hematol Oncol, Vol.30, No.3, pp.150-155, 2012. 

  31. W. Al-Achkar, G. Azeiz, F. Moassass, and A. Wafa, "Influence of CYP1A1, GST polymorphisms and susceptibility risk of chronic myeloid leukemia in Syrian population," Med Oncol, Vol.31, No.5, p.889, 2014. 

  32. W. Al-Achkar, F. Moassass, R. Aroutiounian, T. Harutyunyan, T. Liehr, and A. Wafa, "Effect of Glutathione S-transferase mu 1 (GSTM1) gene polymorphism on chronic myeloid leukemia risk and Imatinib treatment response," Meta gene, Vol.12, pp.113-117, 2017. 

  33. K. Sailaja, D. Surekha, D. N. Rao, D. R. Rao, and S. Vishnupriya, "Association of the GSTP1 gene (Ile105Val) polymorphism with chronic myeloid leukemia," Asian Pac J Cancer Prev, Vol.11, No.2, pp.461-464, 2010. 

  34. T. R. Rebbeck, "Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility," Cancer Epidemiol Biomarkers Prev, Vol.6, No.9, pp.733-743, 1997. 

  35. S. C. Cotton, L. Sharp, J. Little, and N. Brockton, "Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review," Am J Epidemiol, Vol.151, No.1, pp.7-32, 2000. 

  36. C. de Oliveira Hiragi, A. L. Miranda-Vilela, D. M. Rocha, S. F. de Oliveira, A. Hatagima, and M. de Nazare Klautau-Guimaraes, "Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups," Genet Mol Biol, Vol.34, No.1, pp.11-18, 2011. 

  37. M. E. Maciel, F. K. Oliveira, G. B. Propst, M. da Graca Bicalho, I. J. Cavalli, and E. M. Ribeiro, "Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants," Genet Mol Biol, Vol.32, No.4, pp.723-728, 2009. 

  38. E. Zintzaras, "Glutathione S-transferase M1 and T1 genes and susceptibility to chronic myeloid leukemia: a meta-analysis," Genet Test Mol Biomarkers, Vol.13, No.6, pp.791-797, 2009. 

  39. S. Landi, "Mammalian class theta GST and differential susceptibility to carcinogens: a review," Mutat Res, Vol.463, No.3, pp.247-283, 2000. 

  40. M. A. Mehlman, "Causal relationship from exposure to chemicals in oil refining and chemical industries and malignant melanoma," Ann N Y Acad Sci, Vol.1076, pp.822-828, 2006. 

  41. A. Khalade, M. S. Jaakkola, E. Pukkala, and J. J. Jaakkola, "Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis," Environ Health, Vol.9, p.31, 2010. 

  42. E. Zintzaras and J. Lau, "Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches," J Clin Epidemiol, Vol.61, No.7, pp.634-645, 2008. 

  43. E. Zintzaras and J. P. Ioannidis, "Meta-analysis for ranked discovery datasets: theoretical framework and empirical demonstration for microarrays," Comput Biol Chem, Vol.32, No.1, pp.38-46, 2008. 

  44. N. Zdoukopoulos and E. Zintzaras, "Genetic risk factors for placental abruption: a HuGE review and meta-analysis," Epidemiology, Vol.19, No.2, pp.309-323, 2008. 

  45. H. D. Hosgood, 3rd, S. I. Berndt, and Q. Lan, "GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: a meta-analysis," Mutat Res, Vol.636, No.1-3, pp.134-143, 2007. 

  46. E. Zintzaras and G. D. Kitsios, "Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system," Am J Epidemiol, Vol.170, No.6, pp.671-678, 2009. 

  47. H. Bartsch, U. Nair, A. Risch, M. Rojas, H. Wikman, and K. Alexandrov, "Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers," Cancer Epidemiol Biomarkers Prev, Vol.9, No.1, pp.3-28, 2000. 

  48. P. Das, A. P. Shaik, and V. K. Bammidi, "Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia," Leuk Lymphoma, Vol.50, No.8, pp.1345-1351, 2009. 

  49. E. Zintzaras, "Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis," J Hum Genet, Vol.51, No.7, pp.618-624, 2006. 

  50. E. Zintzaras, S. Giannouli, P. Rodopoulou, and M. Voulgarelis, "The role of MTHFR gene in multiple myeloma," J Hum Genet, Vol.53, No.6, pp.499-507, 2008. 

저자의 다른 논문 :

섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로