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NTIS 바로가기대한한방내과학회지 = The journal of internal Korean medicine, v.38 no.5, 2017년, pp.600 - 609
김은지 (목동동신한방병원 한방내과) , 송호준 (목동동신한방병원 침구과) , 김현호 (목동동신한방병원 침구과) , 한양희 (목동동신한방병원 한방내과) , 임정태 (목동동신한방병원 한방내과)
Drug-induced Parkinsonism is the most frequently observed type among the cases of secondary Parkinsonism. Besides typical parkinsonian symptoms, such as tremor, rigidity and bradykinesia, drug-induced Parkinsonism manifests with additional simultaneous symptoms like orobuccolingual dyskinesia, mixed...
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
파킨슨증후군이란? | 파킨슨증후군(Parkinsonism)은 근긴장이상, 무도병, 틱 등과 함께 추체외로증후군(extrapyramidal syndrome, EPS)에 속하며, 진전(tremor), 경축(rigidity), 운동완만증(bradykinesia)의 파킨슨증상을 주증상으로 나타내는 임상적 증후군을 지칭한다1. 파킨슨병(Parkinson’s disease, PD, 이하 PD로 칭한다), 이차성파킨슨증후군(secondary Parkinsonism), 비정형 파킨슨증후군(atypical Parkinsonism) 등이 파킨슨증후군에 속한다2. | |
이차성파킨슨증후군의 원인은? | 파킨슨병(Parkinson’s disease, PD, 이하 PD로 칭한다), 이차성파킨슨증후군(secondary Parkinsonism), 비정형 파킨슨증후군(atypical Parkinsonism) 등이 파킨슨증후군에 속한다2. 이 중 PD는 원인불명으로 흑색질(substantianigra)의 변성에 의해 나타나는 신경변성질환이고, 이차성파킨슨증후군은 약물, 외상, 감염, 종양, 독소 등이 원인이 되어 발생한다. 파킨슨증상의 유발원인 유무여부에 따라 이차성파킨슨증후군은 파킨슨병과 구별된다2. | |
약인 성파킨슨증후군에 대한 적극적인 치료법이 필요한 이유는? | DIP의 증상은 해당 원인 약물을 중단하는 것으로 대부분 4개월 안에 경감 혹 소실되나, 일부에선 약 6-18개월간 지속될 수 있고, 많게는 20%에서 진행 및 악화될 수 있다4. 또한, Chabolla 등의 연구에 따르면, DIP 경험군이 비경험군 보다 PD 발생 위험이 유의하게 높고, 이는 DIP가 PD에 선행할 수 있음을 보여준다4. 따라서, 치료기간의 단축, 질병 진행의 억제, 부작용 및 후유증의 최소화를 위하여 DIP에 대한 적극적인 치료법이 필요하다. 하지만 기존의 양방치료에선 예방이 가장 중요한 요소다. |
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