편의점 안전상비의약품 판매 허용 이후 치료 약물 중독 Pharmaceutical Drug Poisoning after Deregulation of Over the Counter Drug Sales: Emergency Department Based In-depth Injury Surveillance원문보기
Purpose: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence and the clinical outcome of acute pharmaceutical drug poisoning after the deregulation...
Purpose: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence and the clinical outcome of acute pharmaceutical drug poisoning after the deregulation of OTC drug sales. Methods: This study analyzed the data of Emergency Department based Injury In-depth Injury Surveillance (EDIIS), Korea Centers for Disease Control and Prevention, from 2011 to 2014. The following items were examined: age, gender, intention, alcohol association, pharmaceutical drugs resulting acute poisoning, the clinical outcomes in emergency department, and the admission rate of intensive care unit (ICU). This is a retrospective cross section observational study. Results: A total of 10,162 patients were subject to pharmaceutical drug poisoning. Acute poisoning by acetaminophen and other drugs were 1,015 (10.0%) and 9,147 (90.0%) patients, respectively. After the deregulation of OTC drug sales, acute poisoning by other drugs increased from 4,385 to 4,762 patients but acute poisoning by acetaminophen decreased from 538 to 477 patients (p<0.05). The rate of admission of acetaminophen poisoning increased from 36.1% (194/538) to 46.8% (223/477). The admission rate to the ICU by acetaminophen poisoning increased from 4.6% (25/538) to 11.3% (54/477) after the deregulation of OTC drug sales (p<0.05). Conclusion: Since the deregulation of OTC drugs sales, pharmaceutical drug poisoning has increased but acetaminophen poisoning has decreased. The rate of hospitalization and ICU admission by pharmaceutical drug poisoning with or without acetaminophen has also increased.
Purpose: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence and the clinical outcome of acute pharmaceutical drug poisoning after the deregulation of OTC drug sales. Methods: This study analyzed the data of Emergency Department based Injury In-depth Injury Surveillance (EDIIS), Korea Centers for Disease Control and Prevention, from 2011 to 2014. The following items were examined: age, gender, intention, alcohol association, pharmaceutical drugs resulting acute poisoning, the clinical outcomes in emergency department, and the admission rate of intensive care unit (ICU). This is a retrospective cross section observational study. Results: A total of 10,162 patients were subject to pharmaceutical drug poisoning. Acute poisoning by acetaminophen and other drugs were 1,015 (10.0%) and 9,147 (90.0%) patients, respectively. After the deregulation of OTC drug sales, acute poisoning by other drugs increased from 4,385 to 4,762 patients but acute poisoning by acetaminophen decreased from 538 to 477 patients (p<0.05). The rate of admission of acetaminophen poisoning increased from 36.1% (194/538) to 46.8% (223/477). The admission rate to the ICU by acetaminophen poisoning increased from 4.6% (25/538) to 11.3% (54/477) after the deregulation of OTC drug sales (p<0.05). Conclusion: Since the deregulation of OTC drugs sales, pharmaceutical drug poisoning has increased but acetaminophen poisoning has decreased. The rate of hospitalization and ICU admission by pharmaceutical drug poisoning with or without acetaminophen has also increased.
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제안 방법
However, our study could not identify the route of purchase. Second, the serologic test results of acute poisoning patients and the use of antidote were not available; therefore, we reviewed the status of discharge, hospitalization and ICU admissions. However, we could not accurately reflect the severity of acute poisoning patients for several reasons.
대상 데이터
0%) did not show association (Table 3). For the clinical outcome of acute poisoning, 6,489 patients (63.8%) were discharged, and 3,673 patients (36.2%) were general ward and ICU admission, including 16 patients (0.2%) died in emergency room (Table 3).
For this study, we retrospectively analysed Emergency Department Injury In-depth Surveillance (EDIIS) data collected from the emergency rooms of 20 hospitals designated as local or regional emergency medical centres during the four-year period from January 1, 2011, to December 31, 2014. Deregulation of off-pharmacy OTC drug sales began in November 15, 2012.
데이터처리
Categorical variables like sex, results of emergency room examination, intentionality, association with alcohol consumption, and inclusion of acetaminophen are presented as number of cases and frequency (%), while continuous variables like age were analysed with Kolmogorov-Smirnov test and those showing normal distribution are presented as mean with standard deviation. Comparison analysis of before and after allowing sales of 13 OTC drugs in convenience stores other than pharmacies was done with chai-square and independent t test. Statistical analysis was performed with SPSS 21.
성능/효과
According to the results of this study, general ward and ICU admission occurred in 1,670 cases (33.9%) before deregulation of off-pharmacy OTC drug sales and in 1,996 cases (38.2%) after; the rates for ICU admission before and after were 34.9% (495/1,418) and 41.2% (749/1,817), respectively, showing a statistically significant increase (p<0.05).
Categorical variables like sex, results of emergency room examination, intentionality, association with alcohol consumption, and inclusion of acetaminophen are presented as number of cases and frequency (%), while continuous variables like age were analysed with Kolmogorov-Smirnov test and those showing normal distribution are presented as mean with standard deviation. Comparison analysis of before and after allowing sales of 13 OTC drugs in convenience stores other than pharmacies was done with chai-square and independent t test.
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