[논문]고지방식이로 유도된 비만 생쥐모델에서 저령차전자탕의 항비만 효과

장순우; 고영미; 곽진영; 안택원

doi:10.7730/jscm.2018.30.2.8

고지방식이로 유도된 비만 생쥐모델에서 저령차전자탕의 항비만 효과
Anti-obesity Effect of Jeoreongchajeonja-tang in a High-fat Diet-induced Obesity Mouse model 원문보기

JSCM : Journal of Sasang constitutional medicine, v.30 no.2, 2018년, pp.8 - 27

장순우 (대전대학교 한의과대학 사상체질과) , 고영미 (대전대학교 한의과대학 사상체질과) , 곽진영 (대전대학교 한의과대학 사상체질과) , 안택원 (대전대학교 한의과대학 사상체질과)

Abstract ▼ AI-Helper

Objective This study investigated the effects of Jeoreongchajeonja-tang in a high-fat diet-induced obesity mouse model. Methods The study examined 9-week-old male mice (C57bl/6J) divided into four groups: the normal(C57bl/6J-Nr), control (high-fat diet only; HFD-CTL), positive-control (high-fat diet with Garcinia cambogia), and experimental (high-fat diet with Jeoreongchajeonja-tang; HFD-JCT) groups. After 7 weeks, the body weight, food efficiency ratio, organ weight, and visceral fat weight of the mice were measured. Blood serum tests, mRNA, liver histopathology, and epididymis adipocytes were also examined. Results Compared with the Control(HFD-CTL) group, the Experimental(HFD-JCT) group given Jeoreongchajeonja-tang showed significant reductions in absolute body weight and food efficiency ratio. The serum alanine aminotransferase, total-cholesterol, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, insulin-like growth factor-1, and leptin levels were significantly lower in the experimental group than in the control group. The serum adiponectin levels were significantly higher in the experimental group than in the control group. Compared with the control group, the experimental group showed significant reductions in absolute abdominal subcutaneous fat, epididymal adipose tissue, kidney adipose tissue, intestine adipose tissue, and liver, kidney and spleen adipose tissue weights. The C/EBP-${\beta}$, leptin, and SREBP1c/ADD1 mRNA expression were significantly lower in the experimental group than in the control group, while the UCP-2 and adiponectin mRNA expression were significantly higher. Compared with the control group, the experimental group showed a significant reduction in the absolute adipocyte area in the liver and epididymal adipose tissue. Conclusion Jeoreongchajeonja-tang has an anti-obesity effect. Additional clinical studies are expected.

주제어

질의응답

핵심어	질문	논문에서 추출한 답변
	비만 치료약의 2가지 종류는?	비만 치료약들은 현대의학에서 크게 두 가지 카테고리로 분류한다. 첫째는 식욕억제제이고 둘째는 위장관 지방흡수 억제제이다. 식욕억제제는 시상하부의 노르아드레날린, 도파민, 세로토닌 수용체를 대상으로 작용한다.
	비만이란?	과체중과 비만이 다양한 합병증 및 사망과 연관되어 있다는 점은 2500년 전 히포크라테스 시대부터 의료 종사자들에게 알려져 있었다1. 비만은 체내 지방의 과잉 축적 상태로, 비만의 정도가 심할수록 대사 증후군의 빈도 및 합병증이 증가하는데, 비만은 관상동맥질환의 위험을 50% 높일 뿐만 아니라 심혈관계 질환, 관상동맥질환에 의한 사망률을 모두 50% 높인다2. 비만은 인슐린 저항성 및 고혈당, 이상지질혈증을 유발함으로서 제2형 당뇨병 발생 위험성을 증가시키며3, 암의 위험성도 증가시킨다4.
	비만이 유발하는 질병은?	비만은 체내 지방의 과잉 축적 상태로, 비만의 정도가 심할수록 대사 증후군의 빈도 및 합병증이 증가하는데, 비만은 관상동맥질환의 위험을 50% 높일 뿐만 아니라 심혈관계 질환, 관상동맥질환에 의한 사망률을 모두 50% 높인다2. 비만은 인슐린 저항성 및 고혈당, 이상지질혈증을 유발함으로서 제2형 당뇨병 발생 위험성을 증가시키며3, 암의 위험성도 증가시킨다4. 이처럼 비만은 많은 심각한 합병증을 발생시키기에 의학계에서 비만을 조기에 진단하고 치료하는 것은 주요한 관심 사안이며.

참고문헌 (40)

Bray GA. The Battle of the Bulge: A History of Obesity Research, Dorrance, Pittsburgh 2007.
Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The of co-morbidities related to obesity and overweight: a systematic and meta-analysis. BMC Public Health 2009;9:88.

상세보기
Lenz M, Richter T, Muhlhauser I. The morbidity and mortality associated with and obesity in adulthood: a systematic review. Dtsch Arztebl Int 2009;106(40):641-8.
Oh SW, Yoon YS, Shin SA. Effects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol 2005;23(21):4742-54.

상세보기
Kang Jae hun, Kang Joon Goo, Kang Ji Hun et al. Korean Obesity Treatment Guideline 2014, Korean Soceity For The Study Of Obesity, 2014. (Korean)
Dennis L.Kasper, Anthony S.Fauci, Dan L.Longo et al. Harrison's Principles Of Internal Medicine 19th edition McGraw-Hill Education. 2015.
Lee, Sung-Hyun, Lee, Jae-Sung, The Reductive Effects of Oriental Medicine on the Body Fat and Abdominal Obesity, The Society of Korean Medicine for Obesity Research. 2001:1(1):33-42.(Korean)
Moon Soo Jung, Review of Clinical Studies on Oriental Medicine Treatment for Obesity in the Korean Literature, Master Dissertation, Wonkwang University, 2010.(Korean)
Go Ga Yeon, Anti-obesity effect of Yeoldahanso-tang on high fat diet-induced obesity mice. Doctoral Dissertation, Daejeon Universeity, 2016.
Park Jae-Hyoung, Jeon Byung-Hoon, Kim Kyung-Yo, Effects of Ryangkeogsanwhatang on the Adipocyte induced by Gold thioglucose in the Rat, The Journal of Korean Oriental Medical Society 1996:17(2). (Korean)
Go Nam-Gyeong, Lee Yong-Ho, Min Deul-Le, Korean Medical Obesity Treatments on Localized Fat in Three Japanese. J Korean Med Obes Res 2015;15(1):51-54. (Korean)

원문보기 상세보기
Kim Hye-Ju, Ahn Hong-Seok, Oh Eun-Ha, et al. Effect of Taeeumjoweetang on the Body Composition, Serum Lipid Level and Antioxidant Enzyme Activity of Obese Female Colleage Students. 2011;23(3):391-401.(Korean)
Lee Jae Ma, 東醫壽世保元, The 2nd Chapter. 四端論, 2-10,1894.(Korean)
Lee Jae Ma, 東醫壽世保元, The 9th Chapter 脾受寒表寒病論, 9-22,1894.(Korean)
Park Eun-Ah, A clinical case study of Yin Exhausted Syndrome in Two Soyangin Patients, J of Sasang Constitutional Medicine 2006;18(3):210-215.(Korean)
Park In Sun, The Inhibitory effects of So-yangin Bimanbang on the Obese-Mice induced by High-Fat Diet. Master Dissertation, Daejeon University, 2010.
Sung hwan Moon, Byng hee Koh, Il byung Song, The effects of proliferation and differentiation on adipocyte 3T3-L1 by herbs and herbal prescriptions of Soeumin and Soyangin, Journal of KyungHee Oriental Medicine College. 1998:21(1).(Korean)
Hong-won Sik. Hwnag-jenaegyeong. Seoul:Oriental Medicine Research Publication. 1991:61, 94, 219, 220, 275.(Korean)
Kim Sung-Hoon, Lee Byung-Joo. The Discussion of the Concept, Diagnosis, Treatment of Obesity in Korean Medicine References. Journal of Haehwa Medicine. 1998:7(1):533-541.(Korean)
Lee HY, Yoon KH, Seo BI, Park GR, Yoon MC, Shen ZB, Cui HH, Shin SS. Molecular biologic mechanism of obesity by GGEx18. Kor J Herbology. 2011; 26(1):65-74.(Korean)
Jang YJ, Cho JH, Song BJ. Effect of Taeyeumjoweetang and electroacupuncture combined-therapy on obesity. J Korean Orien Assoc Stud Obes. 2001;1(1):77-83.(Korean)
Hwang DS, Ahn SJ, Lee KS, Kim JS, Kim YS, Shin HT. Effect of electro-acupuncture on regional fat by measuring thigh circumstance. J Korean Orient Assoc Stud Obes 2005;5(1):1-8.(Korean)
Choi HS, Choi S, Lee YJ. Compative prospective short-term study on effect of electro-acupuncture on thigh circumference. J Korean Orient Assoc Stud Obes. 2003;3(1):61-7.(Korean)
Kim Kyung-yo et al, The Effect of Taesoeum-in, Soyang-in Prescriptions in a Gold thioglucose induced obesity mouse model. Journal Of Sasang Constitutional Medicine. 1989;3(1):57-61.(Korean)
Lee GJ, Jeon BH, Kim KG. Effects of Taeyeumjoweetang on obesity of mouse and induced adipocyte 3T3-L1. J Sasang Med. 1996;8(2):219-8. (Korean)
Kwon Oh-Won, Kim Bae-Su, Lee Eui-ju et al, The Origin, Changes and Compositive Principles of Jeoryoungchajeonja-tang, J Sasang Constitut Med 2016;28(2):103-109.(Korean)

원문보기 상세보기
Kim Jung-Hwa, Kim Jong-Won. Experimental Atudy on Anti-obesity Effect According to Inhibitory Effect against Lipase Activity of Sasang Constitution Medicines. Korean J. Oriental Physiology & Pathology 2005;19(3):710-715.(Korean)
Bacon BR, Farahvash MJ, Janney CG, Neuschwander-Tetri BA. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994;107:1103.

상세보기
Kathleen DP et al. Mosby's Manual of Diagnostic and Laboratory Tests, fifth Edision. Mosby, 2002.
Stein O, Stein Y. Atheroprotective mechanisms of HDL. Atherosclerosis 1999;144:285-301.

상세보기
Kitamura A, Iso H, Naito Y, et al. High-density lipoprotein cholesterol and premature coronary heart disease in urban Japanese men. Circulation. 1994;89:2533-9.

상세보기
Iuliano L, Mauriello A, Sbarigia E, et al. Radiolabeled native low-density lipoprotein injected into patients with carotid stenosis accumulates in macrophages of atherosclerotic plaque : effect of vitamin E supplementation. Circulation 2000;101:1249.

상세보기
Anderson TJ, Meredith IT, Yeung AC, et al. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 1995; 332:488.

상세보기
Kim JS, Park JH, Cho HS et al. Effect of YGF251 on Secretion of IGF-1 in Human Blood. Korean J. Biotechol. bIOENG. 2002;17(4):403-8.(Korean)
Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004;50:1511.

상세보기
Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941.

상세보기
Brun, R.P., Kim, J.B., Hu, E., et al. Adipocyte differentiation: a transcriptional regulatory cascade. Curr. Opin. Cell. Biol. 1996;8:826-832.

상세보기
Cao Z, Umek RM, McKnight SL. "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 1991;5(9):1538-52.

상세보기
Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 1997:235(1):79-82.

상세보기
Ribot J, Rantala M, Kesaniemi YA, et al. Weight loss reduces expression of SREBP1c/ADD1 and PPARgamma2 in adipose tissue of obese women. Pflugers Arch. 2001;441(4):498-505.

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