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NTIS 바로가기Journal of biomedical engineering research : the official journal of the Korean Society of Medical & Biological Engineering, v.39 no.3, 2018년, pp.109 - 115
이정근 (연세대학교 보건과학대학 의공학부) , 이영훈 (연세대학교 보건과학대학 의공학부) , 박채림 (연세대학교 보건과학대학 의공학부) , 김지현 (연세대학교 보건과학대학 의공학부)
Obesity is a worldwide disease caused by the excessive proliferation of adipocytes. Multiple factors, including melatonin and physical loading, are involved in the control of obesity. Melatonin has been shown to induce apoptosis on preadipocytes while physical loading such as fluid shear stress (FSS...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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비만으로 인한 과도한 에너지 섭취로 인한 지방생성의 특징은? | 지방생성은 지방세포로 분화하기 전 단계인 지방전구세포(preadipocyte)가 성숙한 지방세포로 분화하는 일련의 과정으로, 세포 내 다양한 성장 인자들과 사이토카인(cytokine),호르몬의 영향을 받는다[8,9]. 지방생성을 조절하기 위한 실험에서 주로 mouse embryo 유래의 3T3-L1 지방전구세포가 사용되며[10], 지방전구세포의 세포신호전달에서 열량 보존이 주 역할인 백색 지방의 생성을 조절하는 것으로 알려진 주요 전사 인자들로 peroxisome proliferator-activated receptor gamma (PPARγ)와 CCAAT/enhancer-binding proteins (C/EBPs)가 있다[11]. | |
비만은 무엇인가? | 비만은 과도한 에너지 섭취로 인한 지방 조직의 비정상적인 발달을 특징으로 하는 대사 질환이다. 이는 제 2형 당뇨,심혈관계 질환 등 심각한 합병증을 유발하며[1,2] body mass index (BMI)를 기준으로 30 이상일 시 비만으로 정의한다[3]. | |
비만 인구가 꾸준히 증가하는 원인은 무엇인가? | 이는 제 2형 당뇨,심혈관계 질환 등 심각한 합병증을 유발하며[1,2] body mass index (BMI)를 기준으로 30 이상일 시 비만으로 정의한다[3]. 이 뿐만 아니라 선진국형의 정적인 생활습관과 육류 위주의 식습관으로 인해 비만 인구는 꾸준히 증가하는 추세에 있다[4]. 비만으로 인한 대사 불균형의 직접적인 원인으로는 지방세포의 과잉 증식 및 성장을 꼽을 수 있는데[5], 특히 지방세포의 직경이 커질 경우 인슐린 민감도가 저하되어 혈당 조절에 문제가 생겨 항상성 유지에 있어 지방의 역할을 잃어버리게 된다[6]. |
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