[논문]Progress Towards Control of a Mycobacterial Pathogen, Mycobacterium aviumsubsp. paratuberculosis, the Causative Agent of Johne's Disease in Cattle and Humans

Davis, William C.; Park, Kun Taek

doi:10.13103/jfhs.2018.33.4.221

Progress Towards Control of a Mycobacterial Pathogen, Mycobacterium aviumsubsp. paratuberculosis, the Causative Agent of Johne's Disease in Cattle and Humans 원문보기 논문타임라인

한국식품위생안전성학회지 = Journal of food hygiene and safety, v.33 no.4, 2018년, pp.221 - 228

Davis, William C. (Department of Veterinary Microbiology and Pathology, Washington State University) , Park, Kun Taek (Department of Biotechnology, Inje University)

초록
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19세기말 Mycobacterium avium subsp. paratuberculosis(Map)이 요네병(Johne's disease)의 원인균임이 밝혀진 이후, 불현성 감염된 동물들의 국제적 이동은 요네병을 전세계로 퍼뜨리기 시작하였다. 이러한 요네병이 축산분야에 나타남과 동시에 새로운 형태의 대장염으로서 요네병과 같은 증상을 나타내는 질병(크론병)이 사람에게서도 나타나기 시작하였다. 그러나 Map이 이러한 새로운 대장염의 원인균이며 인수공통전염병의 원인체라는 인식은 20세기 후반 이러한 질병을 앓고 있는 사람의 조직으로부터 Map을 검출할 수 있게 되고서야 나타나기 시작했다. 본 총설은 어떻게 Map이 축산분야와 사람의 공중보건 측면에서 심각한 문제를 야기시키게 되었고, Map 감염에 의한 대장염 환자의 치료가 어떻게 발전되어 왔는지 간단히 요약하고, 축산에서 Map의 통제를 위한 새로운 백신개발 전략에 대하여 소개한다.

Abstract ▼ AI-Helper

Since the discovery that Mycobacterium aviumsubsp. paratuberculosis (Map) is the causative agent of Johne's disease (JD) in cattle at the end of the nineteenth century, movement of livestock latently infected with Map has led to the spread of JD throughout the world. A new form of enteritis with clinical features of JD in cattle appeared in humans concurrent with the appearance of Map as a disease problem in livestock. The demonstration that Map is a zoonotic pathogen and the causative agent of the new form of enteritis in humans, however, wasn't recognized until late in the twentieth century when methods were developed to detect the presence Map in tissues from patients with the new form of clinical enteritis. The objective of this short review is to provide a brief history explaining how Map has become a major disease problem in livestock and humans and then provide a review of the progress that has been made in treating patients with an enteritis caused by Map and the strategies underway to develop a vaccine to control infection in livestock.

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제안 방법

Some Map positive subjects had clinical signs of inflammatory bowel disease (IBD). Later follow up studies reported in a case report of a subject presenting with advanced stages of an inflammatory enteritis including emaciation and continuous bouts of diarrhea, revealed the presence of mycobacteria in his feces detectable by microscopy and acid fast staining. The mycobacterium obtained following culture proved to be the bison strain of Map, the primary strain of Map detected in humans, domestic and wild animals, and the environment in India¹⁶⁾.
Stevenson, collaborative studies led to the sequencing of available isolates of Map obtained from cattle, sheep, and humans¹³⁾. The studies included use of multi-locus sequence polymorphisms to distinguish and compare isolates obtained from domestic species, undomesticated wild species, and humans. Of interest, results from cumulative comparative studies of isolates from different species revealed the presence of isolates of the same phenotype in humans and animals, providing evidence of interspecies transmission as well as susceptibility of humans to infection with Map¹³⁾.

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