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NTIS 바로가기생명과학회지 = Journal of life science, v.28 no.8 = no.220, 2018년, pp.992 - 998
민도식 (부산대학교 자연과학대학 분자생물학과)
Cancer cells grow in an environment composed of various components that supports tumor growth. Major cell types in the tumor microenvironment are fibroblast, endothelial cells and immune cells. All of these cells communicate with cancer cells. Among infiltrating immune cells as an abundant component...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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암세포는 어떠한 환경에서 자라는가? | 암세포는 종양의 성장을 지지하는 다양한 성분으로 구성되어 있는 환경에서 자란다. 암미세환경에 존재하는 주요 세포등은 섬유아세포, 내피세포, 면역세포들이며 이들세포들은 암세포들과 서로 소통을 하고 있다 종양조직에 유입된 면역세포중에서 대식세포가 종양미세환경의 주요성분으로서 다양한 면역현상들을 조절한다. | |
암미세환경에 존재하는 주요 세포는 무엇이 있는가? | 암세포는 종양의 성장을 지지하는 다양한 성분으로 구성되어 있는 환경에서 자란다. 암미세환경에 존재하는 주요 세포등은 섬유아세포, 내피세포, 면역세포들이며 이들세포들은 암세포들과 서로 소통을 하고 있다 종양조직에 유입된 면역세포중에서 대식세포가 종양미세환경의 주요성분으로서 다양한 면역현상들을 조절한다. 면역세포유입에 의한 암촉진과 항암효과 간의 복잡한 균형은 종양의 성장과 진행에 필요한 만성염증 환경을 생성시킬 수 있다. | |
암미세환경에 존재하는 대식세포 이외에 암미세환경을 구성하는 세포는 무엇이 있는가? | 암미세환경에 존재하는 대식세포는 종양의 혈관 생성을 촉진하고 암세포의 이동 및 침윤등을 증가시킨다. 대식세포이외에도 백혈구, 섬유아세포, 혈관내피세포들도 암미세환경을 구성하고 있으며 면역세포들이 암미세환경의 주요 구성성분이다. 이러한 면역세포들이 암세포와 상호작용하여 종양의 개시, 성장, 전이에 영향을 준다[30]. |
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