[논문]Autumn olive (Elaeagnus umbellata Thunb.) berry reduces fasting and postprandial glucose levels in mice

Kim, Jung-In; Baek, Hee-Jin; Han, Do-Won; Yun, Jeong-A

doi:10.4162/nrp.2019.13.1.11

Autumn olive (Elaeagnus umbellata Thunb.) berry reduces fasting and postprandial glucose levels in mice 원문보기

Nutrition research and practice, v.13 no.1, 2019년, pp.11 - 16

Kim, Jung-In (Department of Smart Food and Drug, School of Bio Nano Information Technology, Inje University) , Baek, Hee-Jin (Department of Smart Food and Drug, School of Bio Nano Information Technology, Inje University) , Han, Do-Won (Department of Smart Food and Drug, School of Bio Nano Information Technology, Inje University) , Yun, Jeong-A (Department of Smart Food and Drug, School of Bio Nano Information Technology, Inje University)

Abstract ▼ AI-Helper

BACKGROUND/OBJECTIVES: Fasting and postprandial hyperglycemia should be controlled to avoid complications of diabetes mellitus. This study investigated the effects of autumn olive (Elaeagnus umbellata Thunb.) berry (AOB) on fasting and postprandial hyperglycemia in mice. MATERIALS/METHODS: In vitro ${\alpha}$-glucosidase inhibitory effect of AOB was determined. Maltose solution (2 g/kg) with and without AOB extract at 500 mg/kg or acarbose at 50 mg/kg was orally administered to normal mice after overnight fasting and glucose levels were measured. To study the effects of chronic consumption of AOB, db/db mice received the basal diet or a diet containing AOB extract at 0.4% or 0.8%, or acarbose at 0.04% for 7 weeks. Blood glycated hemoglobin and serum glucose and insulin levels were measured. Expression of adiponectin protein in epididymal white adipose tissue was determined by Western blotting. RESULTS: In vitro inhibitory effect of AOB extract on ${\alpha}$-glucosidase was 92% as strong as that of acarbose. The AOB extract (500 mg/kg) or acarbose (50 mg/kg) significantly suppressed the postprandial rise of blood glucose after maltose challenge and the area under the glycemic response curve in normal mice. The AOB extract at 0.4% or 0.8% of diet or acarbose at 0.04% of diet significantly lowered levels of serum glucose and blood glycated hemoglobin and homeostasis model assessment for insulin resistance values in db/db mice. The expression of adiponectin protein in adipose tissue was significantly elevated by the consumption of AOB at 0.8% of diet. CONCLUSIONS: Autumn olive (E. umbellata Thunb.) berry may reduce postprandial hyperglycemia by inhibiting ${\alpha}$-glucosidase in normal mice. Chronic consumption of AOB may alleviate fasting hyperglycemia in db/db mice partly by inhibiting ${\alpha}$-glucosidase and upregulating adiponectin expression.

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문제 정의

The proanthocyanidins in a grape seed extract improve insulin sensitivity by inducing adiponectin mRNA expression in rats with high-fructose diet-induced insulin resistance [17]. The goal of this study was to investigate the anti-diabetic potential of AOB. The α -glucosidase inhibitory activity of AOB was assessed in vitro.

대상 데이터

A total of 28 male C57BL/KsJ-db/db mice (age, six weeks) were obtained from the Korea Research Institute of Bioscience and Biotechnology (Ochang, Korea).

데이터처리

One-way analysis of variance with a post hoc Tukey test were used to determine significant differences among the groups (P < 0.05).

성능/효과

8% AOB extract, respectively, which replaced cornstarch. Based on a preliminary study, it was assumed that the food intake and average of initial and final body weights of the mice would be 4 g/day and 30 g, respectively. The diets containing 0.
In comparison with the mice fed the basal diet, the HOMA-IR values of the LAOB, HAOB, and acarbose groups were significantly reduced.
In conclusion, AOB reduced postprandial hyperglycemia by inhibiting α-glucosidase in normal mice.
The average daily intake of AOB extract by the LAOB and HAOB groups was calculated to be 502 ± 18 and 1,009 ± 19 mg/kg body weight, respectively, whereas the daily intake of acarbose by the acarbose group was 50 ± 2 mg/kg body weight. The mice received LAOB, HAOB, or acarbose showed lowered HOMA-IR, a surrogate parameter of insulin resistance, compared with the basal diet-fed mice. Clinical trials have confirmed that acarbose monotherapy lowers the fasting blood levels of glucose in patients with type 2 diabetes [27-29].
The mice treated with the AOB extract at 500 mg/kg showed significantly lowered incremental blood glucose levels 30 (P <0.01) and 60 (P < 0.05) min after maltose administration (2 g/kg) compared with the mice administered maltose.

후속연구

Adiponectin has been reported to be anti-inflammatory factor which reduces pro-inflammatory cytokine levels [34]. Thus, further study to determine the anti-inflammatory effect of HAOB in diabetes could be worth-while. The proanthocyanidin-rich extract of grape seed induces adiponectin mRNA expression and the expression of Akt protein, an insulin signaling pathway-related factor, in rats with diet-induced insulin resistance [17].

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