[논문]Anti-Oxidant Effects of Highly Bioavailable Curcumin Powder in High-Fat Diet Fed- and Streptozotocin-Induced Type 2 Diabetic Rats

Paik, Jean Kyung; Yeo, Hee Kyung; Yun, Jee Hye; Park, Hyun-Ji; Jang, Se-Eun

doi:10.9799/ksfan.2019.32.2.133

Anti-Oxidant Effects of Highly Bioavailable Curcumin Powder in High-Fat Diet Fed- and Streptozotocin-Induced Type 2 Diabetic Rats 원문보기

한국식품영양학회지 = The Korean journal of food and nutrition, v.32 no.2, 2019년, pp.133 - 137

Paik, Jean Kyung (Dept. of Food and Nutrition, Eulji University) , Yeo, Hee Kyung (R&D., HANDOK Inc.) , Yun, Jee Hye (R&D., HANDOK Inc.) , Park, Hyun-Ji (Validation Center, ChemOn Inc.) , Jang, Se-Eun (Dept. of Food and Nutrition, Eulji University)

Abstract ▼ AI-Helper

Curcumin is a hydrophobic polyphenol extracted from turmeric that exhibits a variety of biological functions has albeit with limited efficacy as a functional food material owing to its low absorption when administered orally. The newly developed curcumin powder formulation exhibits improved absorption rate in vivo. This study evaluates the anti-oxidant effects of $Theracurmin^{(R)}$ (TC), which is highly bio-available in curcumin powder. The antioxidant activity of TC was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferrous reducing antioxidant power (FRAP) assays, NO radical, superoxide radical, $H_2O_2$ scavenging activity, and total antioxidant capacity (TAC). Additionally, we evaluated the antioxidant activity of TC in high-fat diet (HFD)-fed streptozotocin (STZ)-induced Type 2 diabetic rats. As a result of oral administration of TC for 13 weeks in type 2 diabetic rats, the group administration of 2,000 mg/kg significantly increased FRAP, superoxide dismutase (SOD), and reduced the level of glutathione (GSH) in liver tissue 1.9, 1.2, and 1.2-times, respectively. Furthermore, serum TAC levels increased by 1.3-fold after the rats were administered with a dose of 500 mg/kg. These results were consistent with the in vitro assay results. In conclusion, TC exhibited its potential as a functional food material through its antioxidant properties.

주제어

표/그림 (3)

표 Table 1. Composition of feed
그림 Fig. 1. In vitro antioxidant effects of Theracurmin^® (TC).
표 Table 2. Effect of Theracurmin^® (TC) on blood glucose levels and antioxidant enzyme activities in liver tissue and serum in normal and T2DM rats

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제안 방법

These rats were then continued on HFD until the end of the study. To measure the anti-oxidant effect of TC, type 2 diabetic rats were randomly divided into five groups: untreated control, T2DM control, and 500, 1,000, or 2,000 mg/kg TC treated groups. TC was administered orally once a day for a period of 13 weeks.

대상 데이터

The energy supply of the HFD was as follows (%): fat, 60; carbohydrates, 19; protein, 20 (Table 1). Streptozotocin (STZ) was purchased from Sigma-Aldrich (St. Louis, MO, USA). Commercial assay kits for estimating FRAP, malondialdehyde (MDA) content, SOD content, TAC, and hydrogen peroxide (H₂O₂) content were purchased from Cell biolabs.
The test material TC (kindly provided by Theravalues, Tokyo, Japan) had a curcumin content of 300 mg/g and was prepared by mixing gum ghatti, maltose, citric acid, and dextrin. Turmeric raw material (Curcuma longa L.
The test material TC (kindly provided by Theravalues, Tokyo, Japan) had a curcumin content of 300 mg/g and was prepared by mixing gum ghatti, maltose, citric acid, and dextrin. Turmeric raw material (Curcuma longa L.) was cut and flaked, extracted with hexane and acetone, filtered and concentrated, and the turmeric oleoresin curcumin obtained after drying. Gum ghatti, maltose, citric acid, and dextrin were dissolved in water, and the primary obtained turmeric oleoresin curcumin was added mixed, and ground.

데이터처리

Data were expressed as mean±S.E. The results were analyzed by Student’s t-test.
Student's t-test was used for the parametric comparisons.

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