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NTIS 바로가기韓方眼耳鼻咽喉皮膚科學會誌 = The journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, v.32 no.2, 2019년, pp.94 - 106
손미주 (한국한의학연구원 임상의학부) , 이소민 (한국한의학연구원 임상의학부) , 박성환 (한국한의학연구원 임상의학부) , 김영은 (한국한의학연구원 미래의학부) , 정지연 (한국한의학연구원 임상의학부)
Objectives : This study was conducted to investigate the effects of Gwakhyangjeonggi-san(GJS) on atopic dermatitis(AD) induced by 2,4-dinitrochlorobenzene(DNCB) in mice. Methods : The mice(Balb/c mice) were divided into three groups; normal Balb/c mice with oil treatment(Sham group), DNCB-induced AD...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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아토피 피부염이란? | 아토피 피부염은 영유아기의 흔한 피부 질환 중 하나로 소양감과 피부의 홍반, 부종, 삼출, 태선화 등의 증상이 특징적인 만성 재발성 피부염이다1). 2017년 국민건강영양조사에 따르면 청소년의 25. | |
위장 질환과 아토피 간에 관련이 있는 이유는 무엇인가? | 최근 위장 질환과 아토피 질환과의 관련성이 보고되고 있는데5), 위장은 음식의 소화 흡수로 인체 내 영양분의 원활한 공급하는 기능을 할뿐만 아니라 면역시스템에서의 중요한 작용을 하고 있다6). | |
아토피 피부염의 원인 중에 후천적 소인이 중요하게 작용하고 있음을 나타내는 것은? | 아토피 피부염의 원인은 유전적 소인과 후천적 소인으로 나눌 수 있다. 특히 성인의 아토피 피부염의 증가 추세는 아토피 피부염의 발생과 악화에 있어서 유전적 소인뿐만 아니라 산업화, 주거 행태 및 식습관의 서구화 등으로 인한 생활환경적 요인과 같은 후천적 소인이 중요하게 작용하고 있음을 시사한다4). |
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Kobayashi H, Ishii M, Takeuchi S, Tanaka Y, Shintani T, Yamatodani A, et al. Efficacy and Safety of a Traditional Herbal Medicine, Hochu-ekki-to in the Long-term Management of Kikyo(Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicenter, Double-blind, Randomized, Placebo-controlled Study. Evidence-based Complementary and Alternative Medicine. 2010;7(3):367-73.
Cheng HM, Chiang LC, Jan YM, Chen GW, Li TC. The efficacy and safety of a Chinese herbal product(Xiao-Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial. International Archives of Allergy and Immunology. 2011;155(2):141-8.
Korea Institute of Oriental Medicine. Mediclassics [Internet]. Korea Institute of Oriental Medicine. 2015. [cited 19 Apr 2019]. Available from: URL: https://mediclassics.kr/books/8/volume/10#content_1156
Jeong SJ, Kim OS, Yoo SR, Seo CS, Kim Y, Shin HK. Anti-inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggisan via enhancement of heme oxygenase1 expression in RAW264.7 macrophages. Molecular Medicine Reports. 2016;13(5):4365-71.
Han Y. Experimental study on Huoxiangzhengqi decoction and it's drug-serum against allergic reaction. Kunming: Kunming medical university; 2006.
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Yamaguchi T, Maekawa T, Nishikawa Y, Nojima H, Kaneko M, Kawakita T, et al. Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis. Journal of Dermatological Science. 2001;25(1):20-8.
Indra AK. Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis. Expert Review of Proteomics. 2013;10(4):309-11.
Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunology. 2002;3(7):673-80.
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Serezani APM, Bozdogan G, Sehra S, Walsh D, Krishnamurthy P, Sierra Potchanant EA, et al. IL-4 impairs wound healing potential in the skin by repressing fibronectin expression. The Journal of Allergy and Clinical Immunology. 2017;139(1):142-51.e5.
Leung DYM. Role of IgE in atopic dermatitis. Current Opinion in Immunology. 1993;5(6):956-62.
Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, et al. $TNF-{\alpha}$ and Th2 Cytokines Induce Atopic Dermatitis-Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents. Current Opinion in Immunology. 2014;134(7):1941-50.
Sumimoto S, Kawai M, Kasajima Y, Hamamoto T. Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis. Archives of Disease in Childhood. 1992;67(3):277-9.
Toshitani A, Ansel JC, Chan SC, Li SH, Hanifin JM. Increased Interleukin 6 Production by T Cells Derived from Patients with Atopic Dermatitis. Journal of Investigative Dermatology. 1993;100(3):299-304.
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