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NTIS 바로가기Journal of Korean academy of nursing = 대한간호학회지, v.49 no.3, 2019년, pp.317 - 328
박종민 (경희대학교 간호과학대학) , 김연정 (경희대학교 간호과학대학)
Purpose: The purpose of this study was to identify the effect of ghrelin on memory impairment in a rat model of vascular dementia induced by chronic cerebral hypoperfusion. Methods: Randomized controlled groups and the posttest design were used. We established the representative animal model of vasc...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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저산소증으로 유발된 산화 스트레스는 어떤 현상을 유발하는 가? | VaD를 일으키는 병리적 기전은 아직 명확히 밝혀지지 않았으나, AD와는 달리 만성 대뇌 저관류로 유도된 저산소증으로 인하여 산화 스트레스, 염증, 혈관 및 혈액-뇌 장벽의 손상이 동반된다고 알려져 있다[2]. 현재까지의 연구 결과를 살펴보면 저산소증으로 유발된 산화 스트레스는 미토콘드리아의 기능 이상을 유발하며, 체내의 활성산소를 증가시켜서 혈관과 신경세포에 손상을 일으킨다[3]. 혈류 감소로 인한 저산소증은 또한 미세혈관의 형태 및 기능 이상을 일으켜 내피세포의 기능 장애, 혈액-뇌 장벽의 붕괴 및 염증을 유발한다[4]. | |
그렐린의 투여가 BCCAO로 유발된 VaD 쥐의 기억 손상에 미치는 영향은? | 본 연구는 무작위 대조군 순수 실험연구로 그렐린의 투여가 BCCAO로 유발된 VaD 쥐의 기억 손상에 미치는 영향을 확인하고자 시행되었으며, 행동 실험 및 뇌 조직을 통한 해마와 백색질의 변화를 분자생물학적 기법으로 측정하였다. 본연구의 결과 그렐린 투여 후 백색질 및 해마의 미세혈관 손상이 감소되었고 혈관신생이 증진되었는데, 이는 행동실험의 결과인 공간 학습과 기억의 증진으로 관찰되었다. | |
혈관성 치매(vascular dementia [VaD])는 어떤 질환인가? | 혈관성 치매(vascular dementia [VaD])는 혈관의 폐색이나 혈관질환으로 발생한 만성 대뇌 저관류(chronic cerebral hypoperfusion)로 인하여 뇌의 혈류량이 감소하면서 점진적으로 기억력의 저하, 문제해결능력의 감퇴 및 사고 장애 등의 증상이 나타나는 질환으로 전체 치매 중 알츠하이머성 치매(Alzheimer’s disease [AD]) 다음으로 가장 큰 비율을 차지하고 있다[1]. VaD를 일으키는 병리적 기전은 아직 명확히 밝혀지지 않았으나, AD와는 달리 만성 대뇌 저관류로 유도된 저산소증으로 인하여 산화 스트레스, 염증, 혈관 및 혈액-뇌 장벽의 손상이 동반된다고 알려져 있다[2]. |
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