Objectives: The aim of this study was to investigate the anti-inflammatory effects of Curcuma longa rhizoma extract in an experimental rat model of osteoarthritis. Methods: Osteoarthritis was induced in rats by injecting monosodium iodoacetate (MIA) into the knee joint cavity of rats. The rats were ...
Objectives: The aim of this study was to investigate the anti-inflammatory effects of Curcuma longa rhizoma extract in an experimental rat model of osteoarthritis. Methods: Osteoarthritis was induced in rats by injecting monosodium iodoacetate (MIA) into the knee joint cavity of rats. The rats were divided into 5 groups (Normal, Control, positive comparison, low (CL) and high (CH) concentration groups). Rats in the low concentration (CL) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 50mg/kg body weight. Rats in the high concentration (CH) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 100mg/kg body weight. Hind paw weight distribution and ROS levels were measured. At the end of all treatments, changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine levels were analyzed. In addition, inflammatory protein levels were evaluated by western blot analysis. Results: In this study, hind paw weight distribution significantly improved in the CL and CH groups, while. Reactive oxygen species (ROS) production significantly decreased in both. The levels of ALT, AST, BUN, and creatinine did not significantly change in either group. The production of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), $p47^{phox}$, and Ras-related C3 botulinum toxin substrate 1 (RAC1) decreased in both. Catalase, heme oxygenase-1 (HO-1) and superoxide dismutase (SOD) significantly increased in the CL and CH groups, respectively. Nuclear factor erythroid 2 (Nrf2) increased, but there were no significant differences between the experimental and control groups. Inflammatory cytokines, including nuclear factor-kappa Bp65 (NF-${\kappa}Bp65$), interleukin-1beta (IL-$1{\beta}$), and tumor necrosis factor-alpha (TNF-${\alpha}$), decreased significantly in both the CL and CH groups. Conclusions: Our results showed that Curcuma longa rhizoma extract has anti-inflammatory effects. Anti-inflammatory activity is regulated by the inhibition of inflammatory cytokines and mediators, such as NF-${\kappa}B$, therefore, it suppresses cartilage damage as well.
Objectives: The aim of this study was to investigate the anti-inflammatory effects of Curcuma longa rhizoma extract in an experimental rat model of osteoarthritis. Methods: Osteoarthritis was induced in rats by injecting monosodium iodoacetate (MIA) into the knee joint cavity of rats. The rats were divided into 5 groups (Normal, Control, positive comparison, low (CL) and high (CH) concentration groups). Rats in the low concentration (CL) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 50mg/kg body weight. Rats in the high concentration (CH) group had MIA-induced osteoarthritis; they were treated with Curcuma longa rhizoma extract at a dose of 100mg/kg body weight. Hind paw weight distribution and ROS levels were measured. At the end of all treatments, changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and creatinine levels were analyzed. In addition, inflammatory protein levels were evaluated by western blot analysis. Results: In this study, hind paw weight distribution significantly improved in the CL and CH groups, while. Reactive oxygen species (ROS) production significantly decreased in both. The levels of ALT, AST, BUN, and creatinine did not significantly change in either group. The production of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), $p47^{phox}$, and Ras-related C3 botulinum toxin substrate 1 (RAC1) decreased in both. Catalase, heme oxygenase-1 (HO-1) and superoxide dismutase (SOD) significantly increased in the CL and CH groups, respectively. Nuclear factor erythroid 2 (Nrf2) increased, but there were no significant differences between the experimental and control groups. Inflammatory cytokines, including nuclear factor-kappa Bp65 (NF-${\kappa}Bp65$), interleukin-1beta (IL-$1{\beta}$), and tumor necrosis factor-alpha (TNF-${\alpha}$), decreased significantly in both the CL and CH groups. Conclusions: Our results showed that Curcuma longa rhizoma extract has anti-inflammatory effects. Anti-inflammatory activity is regulated by the inhibition of inflammatory cytokines and mediators, such as NF-${\kappa}B$, therefore, it suppresses cartilage damage as well.
골관절염 (osteoarthritis)은 가장 흔한 형태의 관절염으로 퇴행성 관절염 (degenerative arthritis), 퇴행성 관절질환 (degenerative joint disease) 또는 변형성 관절증 (osteoarthrosis)으로 불리는데1), 체중 부하가 걸리는 고관절 및 슬관절에 호발하며2), 그 유병률은 연령에 비례하여 증가하는 특징을 보여 현대사회의 노령화 추세와 더불어 지속적으로 증가할 것으로 예상된다3).
활성산소종의 역할은 무엇인가?
활성산소종 (Reactive oxygen species, ROS)은 생명체의 세포대사 과정에서 지속적으로 형성이 되는 물질로, ROS가 일정 수준 이상이 되면 병리적 상태가 유발된다43). 이러한 ROS는 O2¯ (superoxide radical), HO¯ (hydroxyl radical), H2O2¯ (hydrogen radical), ROO¯ (peroxyl radical) 등이 주를 이루며44), 세균 감염시 중요한 살균 작용을 하지만, 과다 생성시 발생하는 산화적 스트레스는 염증을 악화시키고 조직에 손상을 주게 되며, 신호 전달 분자의 활성화를 통하여 세포의 사멸을 유도하게 된다45). 본 연구에서 혈청내 ROS를 측정한 결과 CL 투여군, CH 투여군 모두 유의성 있게 감소하였다 (Fig.
골관절염 (osteoarthritis)의 특징은 무엇인가?
골관절염 (osteoarthritis)은 가장 흔한 형태의 관절염으로 퇴행성 관절염 (degenerative arthritis), 퇴행성 관절질환 (degenerative joint disease) 또는 변형성 관절증 (osteoarthrosis)으로 불리는데1), 체중 부하가 걸리는 고관절 및 슬관절에 호발하며2), 그 유병률은 연령에 비례하여 증가하는 특징을 보여 현대사회의 노령화 추세와 더불어 지속적으로 증가할 것으로 예상된다3).
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