Kim, Seon-Kyun
(Department of Food Science and Biotechnology, Kyung Hee University)
,
Guevarra, Robin B.
(Department of Animal Resources Science, Dankook University)
,
Kim, You-Tae
(Department of Food Science and Biotechnology, Kyung Hee University)
,
Kwon, Joongi
(Department of Food Science and Biotechnology, Kyung Hee University)
,
Kim, Hyeri
(Department of Animal Resources Science, Dankook University)
,
Cho, Jae Hyoung
(Department of Animal Resources Science, Dankook University)
,
Kim, Hyeun Bum
(Department of Animal Resources Science, Dankook University)
,
Lee, Ju-Hoon
(Department of Food Science and Biotechnology, Kyung Hee University)
Probiotics, including bacteria and yeast, are live microorganisms that have demonstrated beneficial effects on human health. Recently, probiotic bacteria are constantly being studied and their applications are also being considered in promising adjuvant treatments for various intestinal diseases. Cl...
Probiotics, including bacteria and yeast, are live microorganisms that have demonstrated beneficial effects on human health. Recently, probiotic bacteria are constantly being studied and their applications are also being considered in promising adjuvant treatments for various intestinal diseases. Clinical trials and in vivo experiments have extended our current understanding of the important roles that probiotics play in human gut microbiomeassociated diseases. It has been documented through many clinical trials that probiotics could shape the intestinal microbiota leading to potential control of multiple bowel diseases and promotion of overall wellness. In this review, we focused on the relationship between probiotics and the human gut microbiota and its roles in gut microbiome-associated diseases. Here, we also discuss future directions and research areas that need further elucidation in order to better understand the roles of probiotics in the treatment of intestinal diseases.
Probiotics, including bacteria and yeast, are live microorganisms that have demonstrated beneficial effects on human health. Recently, probiotic bacteria are constantly being studied and their applications are also being considered in promising adjuvant treatments for various intestinal diseases. Clinical trials and in vivo experiments have extended our current understanding of the important roles that probiotics play in human gut microbiomeassociated diseases. It has been documented through many clinical trials that probiotics could shape the intestinal microbiota leading to potential control of multiple bowel diseases and promotion of overall wellness. In this review, we focused on the relationship between probiotics and the human gut microbiota and its roles in gut microbiome-associated diseases. Here, we also discuss future directions and research areas that need further elucidation in order to better understand the roles of probiotics in the treatment of intestinal diseases.
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문제 정의
In addition, although genomic and microbiological characteristics of individual probiotic strains are important, it is necessary to further understand the effect on human gut microbiota during ingestion. This review provides a brief summary of the concept and function of probiotics, and their relationship with intestinal microbiomeassociated diseases [4].
성능/효과
In this study, it has been reported that probiotic intervention may reduce the risk of AAD by 51% with no apparent increase in the risk of side effects [18]. Moreover, combined results in various trials showed that Lactobacillus rhamnosus and Saccharomyces boulardii were the most protective against AAD. Further clinical trials for ADD are summarized in Table 1.
후속연구
Further clinical trials for ADD are summarized in Table 1. However, the exact cause of AAD has not yet been determined, thus further studies are needed to elucidate the underlying mechanisms of AAD as caused by bacterial infection.
However, another recent study demonstrated that multi-strain probiotic adjuvant treatment had no significant changes in intestinal inflammation following the probiotic therapy in patients with CD [21]. Therefore, due to inconsistencies in the results of clinical trials involving probiotic supplementation in the treatment of CD, further research is needed to identify the roles of probiotics.
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