Yoo, Jae Hee
(Department of Acupuncture and Moxibustion medicine, College of Oriental medicine, DongShin University)
,
Ko, Hong Je
(Department of Acupuncture and Moxibustion medicine, College of Oriental medicine, DongShin University)
,
Jeong, Sang Jun
(Department of Acupuncture and Moxibustion medicine, College of Oriental medicine, DongShin University)
,
Kim, Min Wook
(Department of Acupuncture and Moxibustion medicine, College of Oriental medicine, DongShin University)
,
Kim, Soo Hyun
(Department of Acupuncture and Moxibustion medicine, College of Oriental medicine, DongShin University)
,
Kim, Seon Woo
(Department of Acupuncture and Moxibustion medicine, Gwang-ju Jaseng Hospital of Oriental Medicine)
,
Jang, Seung Won
(Department of Acupuncture and Moxibustion medicine, DongShin Korean Medicine Hospital)
,
Shin, Jeong Cheol
(Department of Acupuncture and Moxibustion medicine, College of Oriental medicine, DongShin University)
The aim of this study was to examine pharmacopuncture treatment for lateral epicondylitis, and to contribute to developing a standardized treatment regimen by reviewing trends in clinical trials. Five randomized controlled trials, 1 case-control study, and 8 cohort studies published after 1999, that...
The aim of this study was to examine pharmacopuncture treatment for lateral epicondylitis, and to contribute to developing a standardized treatment regimen by reviewing trends in clinical trials. Five randomized controlled trials, 1 case-control study, and 8 cohort studies published after 1999, that involved pharmacopuncture for lateral epicondylitis, were selected from Korean and international online databases (n = 8). The type of pharmacopuncture, dose, frequency, efficacy, and adverse events were analyzed. Seven types of pharmacopuncture were used, namely Bee Venom, Illicium henryi Diels, Akebiae Caulis, Angelicae sinensis Diels, Ligusticum chuanxiong Hort, Hominis Placenta, and Salviae Miltiorrhizae Radix. Dose, treatment duration, and treatment frequency varied widely. One study assessed the treatment efficacy according to frequency. Nine studies lacked data on adverse events. The quality of 5 randomized controlled trials was low. Although pharmacopuncture treatment appeared to be effective for lateral epicondylitis, it was difficult to standardize the regimen for lateral epicondylitis.
The aim of this study was to examine pharmacopuncture treatment for lateral epicondylitis, and to contribute to developing a standardized treatment regimen by reviewing trends in clinical trials. Five randomized controlled trials, 1 case-control study, and 8 cohort studies published after 1999, that involved pharmacopuncture for lateral epicondylitis, were selected from Korean and international online databases (n = 8). The type of pharmacopuncture, dose, frequency, efficacy, and adverse events were analyzed. Seven types of pharmacopuncture were used, namely Bee Venom, Illicium henryi Diels, Akebiae Caulis, Angelicae sinensis Diels, Ligusticum chuanxiong Hort, Hominis Placenta, and Salviae Miltiorrhizae Radix. Dose, treatment duration, and treatment frequency varied widely. One study assessed the treatment efficacy according to frequency. Nine studies lacked data on adverse events. The quality of 5 randomized controlled trials was low. Although pharmacopuncture treatment appeared to be effective for lateral epicondylitis, it was difficult to standardize the regimen for lateral epicondylitis.
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문제 정의
However, there are no systematic literature reviews that can confirm the safety, methodology and therapeutic effects of pharmacopuncture treatment for lateral epicondylitis. The authors conducted an analysis of the latest clinical studies in Korea and abroad on the treatment of lateral pharmacopuncture. The purpose of this study was to evaluate studies to contribute to developing a standardized treatment regimen for the treatment of lateral epicondylitis.
The authors conducted an analysis of the latest clinical studies in Korea and abroad on the treatment of lateral pharmacopuncture. The purpose of this study was to evaluate studies to contribute to developing a standardized treatment regimen for the treatment of lateral epicondylitis.
제안 방법
There were 12 studies including 2 articles with no access, 9 articles with less than 10 cases, and 1 article with secondary lateral epicondylitis which were also excluded from this current study. A total of 14 articles were selected for this study and were analyzed based on the publication year, research design, number of subjects, treatment method, evaluation index and treatment efficiency. The process of selection of articles was plotted in a flow diagram of Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) as shown in Fig.
Study retrieval and screening was conducted independently by 2 researchers where the titles and abstracts were checked to determine if they fitted the selection criteria for this study. Two researchers reviewed the full articles and agreed upon the selected studies.
The actual search was modified and changed according to the characteristics of each database. When searching Korean and Chinese databases, the above-mentioned English terms were also used.
The clinical tests used to diagnose lateral epicondylitis include Cozen’s test and the Chair test.
Study design of the 14 articles included RCTs, CCS, and CSs. The purpose of the studies was to compare the effect of pharmacopuncture with other treatment in 3 studies, to observe the effect of integrated treatment in 5 studies, to observe the effect of a single treatment in 3 studies, to compare the effects of additional treatments with existing treatments in 2 studies, and compare the integrated effect with other treatments in 1 study. Since steroid injections are widely used as a conservative treatment, 3 studies comparing the treatment efficacy of pharmacopuncture and steroid injections may be of great clinical value.
However, there was no analysis of the research trends of pharmacopuncture for lateral epicondylitis. The purpose of this study was to evaluate the efficacy of pharmacopuncture used for lateral epicondylitis and standardized the treatment of lateral epicondylitis with pharmacopuncture. Therefore, the types, doses, and treatment efficacy of pharmacopuncture was analyzed by performing a literature review of 8 online databases (PubMed, Cochrane, EMBASE, CNKI, NDSL, OASIS, KISS and RISS).
Using EndNote X8.2 the selected articles were reviewed for title, first author, publication year, type of research, number of subjects, treatment content, number and duration treatment, and adverse events.
대상 데이터
A total of 209 articles were retrieved from PubMed (n = 8), Cochrane (n = 4), EMBASE (n = 17), CNKI (n = 136), NDSL (n = 19), OASIS (n = 4), KISS (n = 12) and RISS (n = 9). Of these, 42 duplications were removed.
A total of 8 online databases were used to retrieve studies up to October 20, 2018, including 4 international online databases [Pubmed, Cochrane library, Excerpta Medica database (EMBASE), China National Knowledge Ingrastructure (CNKI)], and 4 Korean online databases [National Digital Science Links (NDSL), Oriental medicine Advanced Searching Integrated System (OASIS), Korean studies Information Service System (KISS), Research Information Sharing Service (RISS)] shown in Table 1.
There were 21 studies performed before 1999, and 120 which did not apply pharmacopuncture for lateral epicondylitis. After the first screening, there were 26 articles left to review. There were 12 studies including 2 articles with no access, 9 articles with less than 10 cases, and 1 article with secondary lateral epicondylitis which were also excluded from this current study.
The highest number of studies were published in 2012 (n = 4). Study design of the 14 articles included RCTs, CCS, and CSs. The purpose of the studies was to compare the effect of pharmacopuncture with other treatment in 3 studies, to observe the effect of integrated treatment in 5 studies, to observe the effect of a single treatment in 3 studies, to compare the effects of additional treatments with existing treatments in 2 studies, and compare the integrated effect with other treatments in 1 study.
There were 8 studies published within the last 10 years, of which 4 studies were published in 2012. The study design of the included articles were RCT (n = 5), CCS (n = 1) and CS (n = 8). No SR were performed with pharmacopuncture for lateral epicondylitis.
There were a total of 1,214 participants across all studies. The smallest study had 13 participants in the intervention group and 21 subjects in the control group.
성능/효과
The 7 types of pharmacopuncture used in the treatment were 6 kinds of BV, 2 kinds of Illicium henryi Diels, 2 kinds of Akebiae Caulis, 1 piece of Angelicae sinensis Diels, 1 piece of Ligusticum chuanxiong Hort, 1 mixture of Ligusticum chuanxiong Hort and Hominis Placenta and 1 mixture of Salviae Miltiorrhizae Radix and Akebiae Caulis. BV seems to be most actively studied in clinical practice, and it seems to have treatment efficacy through BV counter stimulation effects, immunoregulatory action, and circulation facilitation action [38].
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