[논문]인공 항원제시세포의 표면 분자의 특성 및 상호작용이 T 세포 활성화에 미치는 영향

민영실; 강윤중

doi:10.22156/cs4smb.2020.10.06.164

[국내논문] 인공 항원제시세포의 표면 분자의 특성 및 상호작용이 T 세포 활성화에 미치는 영향
The effects of properties and interactions of surface molecules in antigen presenting cells on T cell activation 원문보기

융합정보논문지 = Journal of Convergence for Information Technology, v.10 no.6, 2020년, pp.164 - 176

민영실 (중원대학교 제약공학과) , 강윤중 (중원대학교 의생명과학과)

초록
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인체 적응 면역 반응을 일으키는데 중요한 항원 특이적 T 세포를 활용한 면역 세포 치료에서 T 세포를 체외에서 배양하고 클론 확장시키는 과정은 매우 섬세하고 복잡하여 조절하기가 쉽지 않아 T 세포의 활성화와 클론 확장을 유도하면서도 조절 및 취급이 용이한 인공 항원제시세포 개발의 필요성이 대두되고 있다. 인공 항원제시세포는 인체의 항원제시세포의 세포 표면 분자와 작용을 모방하게 되는데, 기본적인 신호 분자인 MHC-항원 복합체, 공동 자극 분자, 그리고 용해성 면역 조절 분자를 필수적으로 발현하여야 한다. 또한 T 세포가 항원과 접촉할 때, 이들 분자들이 잘 조직화되어 작용하는 것이 효과적인 T 세포 활성화에 중요하다. 본 논문에서는 여러 인공 항원제시세포 제작 방법과 세포 표면 분자들의 결합 방법과 물리적인 특성이 T 세포와의 상호작용에 중요함을 고찰하였으며, 효과적인 T 세포 활성화를 유도하며 면역세포치료에 적용 가능한 인공항원제세세포의 제작 방법을 살펴보았다.

Abstract ▼ AI-Helper

Efficient production of antigen specific cytotoxic T cells is critical for appropriate adoptive immune response. In vitro culture and expansion of human T lymphocyte clones are very sophisticated and subtle procedure in immune cell therapy and hard to control. Therefore, many groups devoted their efforts to manipulate artificial antigen presenting cells (aAPCs) that can induce T cell activation and clonal expansion. To mimicking of natural antigen-presenting cells, aAPCs encompass basic signal molecules required for T cell activation: MHC:antigen complexes, co-stimulatory molecules and soluble immune modulating molecules. Orchestrated organization of these molecules is important for efficient T cell activation. Here, we discuss how those molecules have been incorporated in several aAPC models, but also how physical properties od aAPC are important for interaction with T cells.

주제어

표/그림 (4)

그림 Fig. 1. Antigen capture and presentation by antigen presenting cells.
그림 Fig. 2. Three ligands (recognition (red), costimulatory (green), and adhesion (blue)) that could be presented on the surface of artificial antigen presenting cells (aAPCs) in various ways.
그림 Fig. 3. Recruitment of Alexa Fluor 647-labelled SP94 peptides (white) to the surface of a Hep3B cell when peptides are displayed on a nitrobenzoxadiazole-labelled SLB (green) composed of DOPC (open circles) or DPPC (closed circles).
그림 Fig. 4. Schematic of signal classes presented by an antigen presenting cell (APC).

AI 본문요약
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문제 정의

This article explores the role of scaffold properties in cellular interactions and signaling procedures. Focus will be on the biomimicry of APCs in the context of cancer immunotherapy using artificial scaffolds.

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표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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