최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Journal of dairy science and biotechnology, v.38 no.1, 2020년, pp.27 - 36
윤정희 (농촌진흥청 국립축산과학원) , 설국환 (농촌진흥청 국립축산과학원) , 유자연 (농촌진흥청 국립축산과학원) , 오미화 (농촌진흥청 국립축산과학원) , 함준상 (농촌진흥청 국립축산과학원)
The prevention of cognitive decline and dementia is an increasingly important global public health priority due to an increase in the percentage of the elderly population. Dementia, a severe cognitive disorder, not only negatively impacts the patients' quality of life but also creates a substantial ...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
알츠하이머병은 조직병리학적 특성으로 무엇이 존재하는가? | 가장 일반적인 형태의 치매는 알츠하이머병으로 치매 환자의 50%–70%를 차지한다. 알츠하이머병은 베타 아밀로이드(Aβ) 플라그와 과인산화 타우(tau) 단백질로 구성된 세포내 신경원섬유매듭(NFTs)의 존재하는 조직병리학적 특성이 있다. 노인성의 베타 아밀로이드 플라그와 NFTs는 불용성의 밀집한 단백질 섬유를 형성한다. | |
유제품 섭취에 의한 치매 및 인지 저하 예방 효과에 관한 연구에서 효과 물질로 무엇이 논의되었는가? | 이들 문제와 관련한 보고들은 치매 예방을 위한 새로운 접근법 개발에 도움이 될 것이다. Oleamide와 dehydroergosterol이 유제품내 효과 물질로 논의되었다. 그런데, 발효중 생산되는 다양한 지방산과 펩타이드의 기능은 밝혀지지 않았다. | |
알츠하이머병 이외 일반적 형태의 치매에는 무엇이 있는가? | 베타 아밀로이드 플라그와 NFTs의 축적은 알츠하이머병의 증상과 관련이 있고, 신경 손상과 사망에 이르게 된다[1–4]. 다른 일반적 형태의 치매에는 혈관성 치매[5], 루이 소체(Lewy body) 치매[6], 그리고 전측두엽 치매[7]가 있다. 많은 보고에서 뇌에 베타 아밀로이드 플라그 형성 후 염증이 따르는데, 이는 NFTs와 밀접한 관련이 있고, 알츠하이머병의 진전을 가속한다[2, 4, 8, 9]. |
Bloom GS. Amyloid- ${\beta}$ and tau: the trigger and bullet in Alzheimer disease pathogenesis. JAMA Neurol. 2014;71:505-508.
Congdon EE, Sigurdsson EM. Tau-targeting therapies for Alzheimer disease. Nat Rev Neurol. 2018;14:399-415.
Polanco JC, Li C, Bodea LG, Martinez-Marmol R, Meunier FA, Gotz J. Amyloid- ${\beta}$ and tau complexity-towards improved biomarkers and targeted therapies. Nat Rev Neurol. 2018;14:22-39.
Takashima A. Amyloid-beta, tau, and dementia. J Alzheimers Dis. 2009;17:729-736.
Kalaria RN. The pathology and pathophysiology of vascular dementia. Neuropharmacology. 2018;134:226-239.
Mueller C, Ballard C, Corbett A, Aarsland D. The prognosis of dementia with Lewy bodies. Lancet Neurol. 2017;16:390-398.
Silveri MC. Frontotemporal dementia to Alzheimer's disease. Dialogues Clin Neurosci. 2007;9:153-160.
Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015;16:358-372.
Ransohoff RM. Specks of insight into Alzheimer's disease. Nature. 2017;552:342-343.
Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390:2673-2734.
Caruso A, Nicoletti F, Mango D, Saidi A, Orlando R, Scaccianoce S. Stress as risk factor for Alzheimer's disease. Pharmacol Res. 2018;132:130-134.
Lourida I, Soni M, Thompson-Coon J, Purandare N, Lang IA, Ukoumunne OC, et al. Mediterranean diet, cognitive function, and dementia: a systematic review. Epidemiology. 2013;24:479-489.
Petersson SD, Philippou E. Mediterranean diet, cognitive function, and dementia: a systematic review of the evidence. Adv Nutr. 2016;7:889-904.
Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, et al. Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;39:271-282.
Crupi R, Marino A, Cuzzocrea S. n-3 fatty acids: role in neurogenesis and neuroplasticity. Curr Med Chem. 2013;20:2953-2963.
Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52.
Freitas HR, Ferreira GDC, Trevenzoli IH, Oliveira KJ, de Melo Reis RA. Fatty acids, antioxidants and physical activity in brain aging. Nutrients. 2017;9:1263.
Heras-Sandoval D, Pedraza-Chaverri J, Perez-Rojas JM. Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer's disease. J Neuroinflammation. 2016;13:61.
Bastianetto S, Menard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015;1852:1195-1201.
Sawda C, Moussa C, Turner RS. Resveratrol for Alzheimer's disease. Ann NY Acad Sci. 2017;1403:142-149.
Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, et al. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015;85:1383-1391.
Botchway BOA, Moore MK, Akinleye FO, Iyer IC, Fang M. Nutrition: review on the possible treatment for Alzheimer's disease. J Alzheimers Dis. 2018;61:867-883.
Goozee KG, Shah TM, Sohrabi HR, Rainey-Smith SR, Brown B, Verdile G, et al. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. Br J Nutr. 2016;115:449-465.
Reddy PH, Manczak M, Yin X, Grady MC, Mitchell A, Tonk S, et al. Protective effects of indian spice curcumin against amyloid- ${\beta}$ in Alzheimer's disease. J Alzheimers Dis. 2018;61:843-866.
Camfield DA, Owen L, Scholey AB, Pipingas A, Stough C. Dairy constituents and neurocognitive health in ageing. Br J Nutr. 2011;106:159-174.
Crichton GE, Bryan J, Murphy KJ, Buckley J. Review of dairy consumption and cognitive performance in adults: findings and methodological issues. Dement Geriatr Cogn Disord. 2010;30:352-361.
Crichton GE, Murphy KJ, Bryan J. Dairy intake and cognitive health in middle-aged South Australians. Asia Pac J Clin Nutr. 2010;19:161-171.
Dik MG, Jonker C, Comijs HC, Deeg DJ, Kok A, Yaffe K, et al. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care. 2007;30:2655-2660.
Raffaitin C, Gin H, Empana JP, Helmer C, Berr C, Tzourio C, et al. Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the three-city study. Diabetes Care. 2009;32:169-174.
Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi T, Azizi F. Beneficial effects of a dietary approaches to stop hypertension eating plan on features of the metabolic syndrome. Diabetes Care. 2005;28:2823-2831.
Major GC, Chaput JP, Ledoux M, St-Pierre S, Anderson GH, Zemel MB, et al. Recent developments in calcium-related obesity research. Obes Rev. 2008;9:428-445.
Zemel MB. Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr. 2004;79:907S-912S.
Choi HK, Willett WC, Stampfer MJ, Rimm E, Hu FB. Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med. 2005;165:997-1003.
Liu S, Choi HK, Ford E, Song Y, Klevak A, Buring JE, et al. A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care. 2006;29:1579-1584.
Rahman A, Sawyer Baker P, Allman RM, Zamrini E. Dietary factors and cognitive impairment in community-dwelling elderly. J Nutr Health Aging. 2007;11:49-54.
Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, et al. Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. Am J Clin Nutr. 2013;97:1076-1082.
Hoffmann K, Schulze MB, Schienkiewitz A, Nothlings U, Boeing H. Application of a new statistical method to derive dietary patterns in nutritional epidemiology. Am J Epidemiol. 2004;159:935-944.
Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, et al. Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama study. J Am Geriatr Soc. 2014;62:1224-1230.
Ogata S, Tanaka H, Omura K, Honda C, Hayakawa K. Association between intake of dairy products and short-term memory with and without adjustment for genetic and family environmental factors: a twin study. Clin Nutr. 2016;35:507-513.
Markus CR, Olivier B, de Haan EH. Whey protein rich in alpha-lactalbumin increases the ratio of plasma tryptophan to the sum of the other large neutral amino acids and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr. 2002;75:1051-1056.
Markus CR, Olivier B, Panhuysen GE, Van Der Gugten J, Alles MS, Tuiten A, et al. The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Am J Clin Nutr. 2000;71:1536-1544.
Ano Y, Ozawa M, Kutsukake T, Sugiyama S, Uchida K, Yoshida A, et al. Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity. PloS One. 2015;10:e0118512.
Sarlus H, Heneka MT. Microglia in Alzheimer's disease. J Clin Invest. 2017;127:3240-3249.
Visan I. Alzheimer's disease microglia. Nat Immunol. 2017;18:876.
Lee CY, Landreth GE. The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna). 2010;117:949-960.
Hansen DV, Hanson JE, Sheng M. Microglia in Alzheimer's disease. J Cell Biol. 2018;217:459-472.
Imbimbo BP, Solfrizzi V, Panza F. Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment? Front Aging Neurosci. 2010;2:19.
Miguel-Alvarez M, Santos-Lozano A, Sanchis-Gomar F, Fiuza-Luces C, Pareja-Galeano H, Garatachea N, et al. Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer's disease: a systematic review and meta-analysis of treatment effect. Drugs Aging. 2015;32:139-147.
Stewart WF, Kawas C, Corrada M, Metter EJ. Risk of Alzheimer's disease and duration of NSAID use. Neurology. 1997;48:626-632.
Wang J, Tan L, Wang HF, Tan CC, Meng XF, Wang C, et al. Anti-inflammatory drugs and risk of Alzheimer's disease: an updated systematic review and meta-analysis. J Alzheimers Dis. 2015;44:385-396.
Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, et al. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009;119:3692-3702.
Wyss-Coray T, Mucke L. Ibuprofen, inflammation and Alzheimer disease. Nat Med. 2000;6:973-974.
Ano Y, Kutsukake T, Hoshi A, Yoshida A, Nakayama H. Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum. PloS One. 2015;10:e0116598.
Awasthi NP, Singh RP. Lipase-catalyzed synthesis of fatty acid amide (erucamide) using fatty acid and urea. J Oleo Sci. 2007;56:507-509.
Slotema WF, Sandoval G, Guieysse D, Straathof AJ, Marty A. Economically pertinent continuous amide formation by direct lipase-catalyzed amidation with ammonia. Biotechnol Bioeng. 2003;82:664-669.
Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 1996;384:83-87.
Boger DL, Henriksen SJ, Cravatt BF. Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Curr Pharm Des. 1998;4:303-314.
Prospero-Garcia O, Amancio-Belmont O, Becerril Melendez AL, Ruiz-Contreras AE, Mendez-Diaz M. Endocannabinoids and sleep. Neurosci Biobehav Rev. 2016;71:671-679.
Cassano T, Calcagnini S, Pace L, De Marco F, Romano A, Gaetani S. Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target. Front Neurosci. 2017;11:30.
Mecha M, Carrillo-Salinas FJ, Feliu A, Mestre L, Guaza C. Microglia activation states and cannabinoid system: therapeutic implications. Pharmacol Ther. 2016;166:40-55.
Navarro G, Morales P, Rodriguez-Cueto C, Fernandez-Ruiz J, Jagerovic N, Franco R. Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders. Front Neurosci. 2016;10:406.
Tachibana Y. Synthesis and structure-activity relationships of bioactive compounds using sterols. Yakugaku Zasshi. 2006;126:1139-1154.
Wustner D. Fluorescent sterols as tools in membrane biophysics and cell biology. Chem Phys Lipids. 2007;146:1-25.
Wu Y, Dissing-Olesen L, MacVicar BA, Stevens B. Microglia: dynamic mediators of synapse development and plasticity. Trends Immunol. 2015;36:605-613.
Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol. 2016;16:22-34.
Salim S, Chugh G, Asghar M. Inflammation in anxiety. Adv Protein Chem Struct Biol. 2012;88:1-25.
Komaroff AL. Inflammation correlates with symptoms in chronic fatigue syndrome. Proc Natl Acad Sci USA. 2017;114:8914-8916.
Amor S, Peferoen LA, Vogel DY, Breur M, van der Valk P, Baker D, et al. Inflammation in neurodegenerative diseases-an update. Immunology. 2014;142:151-166.
Sue W, Griffin T. Inflammation and neurodegenerative diseases. Am J Clin Nutr. 2006;83:470S-474S.
Kruk-Slomka M, Michalak A, Biala G. Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: mechanism of action and possible interactions with cholinergic system. Behav Brain Res. 2015;284:24-36.
Ano Y, Nakayama H. Preventive effects of dairy products on dementia and the underlying mechanisms. Int J Mol. 2018;19:E1927.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.