[논문]A Study of the Initial Dose of Sweet Bee Venom for the Treatment of Patients with Lower Back Pain

Lee, Kwang Ho

doi:10.13045/jar.2020.00227

A Study of the Initial Dose of Sweet Bee Venom for the Treatment of Patients with Lower Back Pain 원문보기

Journal of acupuncture research, v.37 no.3, 2020년, pp.173 - 176

Lee, Kwang Ho (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University)

Abstract ▼ AI-Helper

Sweet bee venom (SBV) causes less hypersensitivity reactions compared with whole bee venom. To determine the appropriate SBV initial dose for pharmacopuncture treatment of lower back pain, the initial dose, and the dose which caused hypersensitivity were retrospectively reviewed between January 1st, 2017 and December 31st, 2019. There were 523 first-visit patients who received SBV pharmacopuncture for lower back pain and 41 showed hypersensitivity. No systemic reactions were observed and localized reactions were not severe. Hypersensitivity was observed during the first (7 cases), and fifth treatments (8 cases). An initial SBV (10%) volume of 0.1 mL was used in 2 cases, 0.2 mL in 6 cases, 0.6 mL in 41 cases, and 1.2 mL in 474 cases. The hypersensitivity rate during the first and fifth treatment was 1.34% and 1.53%, respectively. As a result, 1.2 mL of SBV was considered the acceptable initial dose. However, for safer treatment, we recommend limiting the initial dose of SBV to 0.5 mL.

주제어

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제안 방법

In this case report, the initial SBV volume used in all patients was reviewed. Hypersensitivity, and the dose used when hypersensitivity occurred, the treatment schedule which caused hypersensitivity, and the methods used to treat these reactions were investigated. This study was approved by the institutional review board (IRB) of Korean medicine hospital of Sangji University (no.
This study retrospectively analyzed the medical records of patients who received SBV pharmacopuncture in the Department of Acupuncture over the last 3 years to identify the initial dose and the dose at which hypersensitivity was caused by SBV.
This study was limited to patients with low back pain to exclude characteristics according to the treatment area, and various disease-specific differences. All 523 patients were enrolled according to the following inclusion and exclusion criteria.

대상 데이터

This was a retrospective study of 523 first-visit patients who underwent BVP for lower back pain in Acupuncture Department 2, the Korean Medicine Hospital, Sangji University, from January 1^st, 2017 to December 31^st, 2019. In this case report, the initial SBV volume used in all patients was reviewed.

성능/효과

SBV (Kirin Korean medicine extramural herbal dispensary facility, Wonju, Korea) pharmacopuncture was used for treatment for lower back pain patients. Firstly, SBV 10% (1:10,000) was used, followed by SBV 50% (1:2,000) when the usage capacity of SBV 10% was increased. When SBV 50% was used, the dose was calculated by converting it to the SBV 10% dose.
Of the 523 patients in this study, 1.2 mL was used as a treatment volume in 474 cases and since SBV was used instead of whole bee venom, the initial dose in 1.2 mL caused only 8 cases of mild hypersensitivity, therefore it was considered an acceptable initial dose. There were 41 hypersensitivity, which accounted for 7.

후속연구

5 mL of SBV 10% for low back pain patients, which corresponds to the skin test volume of Apitoxin as the initial dose, and more data should be accumulated to verify the safe initial dose of SBV. In addition, since allergy testing is considered to be important when using bee venom, I hope that there will be a study to investigate the relationship between allergy testing and initial dose of SBV in the future.

참고문헌 (17)

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원문보기 상세보기
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원문보기 상세보기
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원문보기 상세보기
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상세보기
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상세보기
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상세보기
Della-Torre E, Lanzillotta M, Doglioni C. Immunology of IgG4-related disease. Clin Immunol 2015;181:191-206.

상세보기
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A Study of the Initial Dose of Sweet Bee Venom for the Treatment of Patients with Lower Back Pain 원문보기

Abstract ▼ AI-Helper

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A Study of the Initial Dose of Sweet Bee Venom for the Treatment of Patients with Lower Back Pain 원문보기

Abstract ▼ AI-Helper

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제안 방법

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참고문헌 (17)

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