[논문]소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과

조주현; 임지성; 김종규; 박중현; 최학순; 황규원; 송용선

doi:10.18325/jkmr.2021.31.1.33

소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과
Anti-Arthritic Effect of Sogyunghwalhyel-tang-gamibang 원문보기

Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, v.31 no.1, 2021년, pp.33 - 46

조주현 (원광대학교 한의과대학 한방재활의학교실) , 임지성 (원광대학교 한의과대학 한방재활의학교실) , 김종규 (원광대학교 한의과대학 한방재활의학교실) , 박중현 (원광대학교 한의과대학 한방재활의학교실) , 최학순 (원광대학교 한의학전문대학원 제3의학과) , 황규원 (원광대학교 한의학전문대학원 제3의학과) , 송용선 (원광대학교 한의학전문대학원 제3의학과)

Abstract ▼ AI-Helper

Objectives The aim of this study is to evaluate anti-inflammatory and anti-arthritic effects of Sogyunghwalhyel-tang-gamibang (SGHHTGB) in cell and animal models and also to suggest one of putative mechanisms underlying its anti-arthritic effects. Methods Enzyme-linked immunosorbent assay was applied to measure the concentrations of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in culture medium and blood serum and nitric oxide (NO) was assayed by Griess reagent. The expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) were analyzed by Western blot method. Results In a cell model using RAW264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS), the drug, at its non-cytotoxic concentrations, inhibited the production of the pro-inflammatory cytokine TNF-α, IL-1β and IL-6. In addition, it suppressed the expression of the inflammatory enzyme iNOS and COX-2, and reduced the synthesis of the enzyme product NO (as stable nitrite) and PGE2 in activated macrophages. Meanwhile, in an animal model using rheumatic arthritis (RA) mice induced with injection of type II collagen antibody (CAb) and LPS, the drug improved clinical symptom of arthritis and reduced paw thickness and inflammatory cell infiltration. In blood of RA mice, the drug reduced serum levels of TNF-α, IL-1β, IL-6, nitrite, and PGE2, all inflammatory mediators produced by activated macrophages. Conclusions SGHHTGB may ameliorate CAb and LPS-induced RA in mice, presumably by inactivating macrophages that are capable of initiating joint inflammation by producing pro-inflammatory cytokines and expressing inflammatory enzymes.

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소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과
Anti-Arthritic Effect of Sogyunghwalhyel-tang-gamibang 원문보기

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소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과 Anti-Arthritic Effect of Sogyunghwalhyel-tang-gamibang 원문보기

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참고문헌 (46)

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소경활혈탕가미방(疎經活血湯加味方)의 관절염에 미치는 효과
Anti-Arthritic Effect of Sogyunghwalhyel-tang-gamibang 원문보기