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고지방 식이 유도 고지혈증에 대한 ChondroT의 혈액 내 지질대사에 미치는 영향
Observational Study of ChondroT's Improvement of Blood Metabolites in High-fat Diet-induced Hyperlipidemia 원문보기

Journal of Korean Medicine Rehabilitation : JKMR = 한방재활의학과학회지, v.31 no.1, 2021년, pp.81 - 93  

윤찬석 (동신대학교 한의과대학 한방재활의학과교실) ,  김도형 (동신대학교 한의과대학 한방재활의학과교실) ,  나창수 (동신대학교 한의과대학 경혈학교실) ,  정지원 (전라남도 영암군보건소) ,  김지훈 (동신대학교 한의과대학 한방재활의학과교실) ,  김선길 (동신대학교 한의과대학 한방재활의학과교실) ,  최지민 (동신대학교 한의과대학 한방재활의학과교실) ,  김선종 (동신대학교 한의과대학 한방재활의학과교실)

Abstract AI-Helper 아이콘AI-Helper

Objectives The objective of the study was to investigate effects of ChondroT by improvement of blood metabolites in high-fat diet (HFD)-induced hyperlipidemia rat model. Methods Sprague-Dawley rats were randomly assigned to intact, control, simvastatin, and CT100, CT200 and CT400 (each n=6). For obs...

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참고문헌 (48)

  1. Aspden RM. Obesity punches above its weight in osteoarthritis. Nat Rev Rheumatol. 2011;7(1):65-8. 

  2. Pottie P, Presle N, Terlain B, Netter P, Mainard D, Berenbaum F. Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis. 2006;65(11):1403-5. 

  3. Niu J, Clancy M, Aliabadi P, Vasan R, Felson DT. Metabolic syndrome, its components, and knee osteoarthritis: the framingham osteoarthritis study. Arthritis Rheumatol Hoboken NJ. 2017;69(6):1194-203. 

  4. Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012;8(12):729-37. 

  5. Won JY, Jeong JW, Na CS, Kim SJ. Analgesic effects of ChondroT in collagenase-induced osteoarthritis rat model. J Korean Med Rehabil. 2016;26(3):17-30. 

  6. Park JU, Kim SJ, Na CS, Choi CH, Seo CS, Son JK, Kang BY, Kim YR. Chondroprotective and anti-inflammatory effects of ChondroT, a new complex herbal medication. BMC Complement Altern Med. 2016; 16(1):213. 

  7. Jeong JW, Bae KJ, Kim SG, Kwak DW, Moon YJ, Choi CH, Kim YR, Na CS, Kim SJ. Anti-osteoarthritic effects of ChondroT in a rat model of collagenase-induced osteoarthritis. BMC Complement Altern Med. 2018; 18(1):131. 

  8. Kim SG, Jeong JW, Lim YH, Kim JH, Na CS, Kim SJ. A study on the anti-condensing effect of ChondroT components. J Korean Med Rehabil. 2018;28(2):47-60. 

  9. Musa-Veloso K, Poon TH, Elliot JA, Chung C. A com- parison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2011;85(1):9-28. 

  10. Bae KJ, Jeong JW, Choi CH, Won JY, Kim TG, Kim YR, Na CS, Kim SJ. Antiosteoarthritic effects of ChondroT in a rat model of monosodium iodoacetate-induced osteoarthritis. Evid Based Complement Alternat Med. 2018;2018:1-11. 

  11. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet Lond Engl. 2011;378(9786):169-81. 

  12. Datta P, Zhang Y, Parousis A, Sharma A, Rossomacha E, Endisha H, Wu B, Kacprzak I, Mahomed NN, Gandhi R, Rockel JS, Kapoor M. High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature. Sci Rep. 2017;7(1):8205. 

  13. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, SmithJr SC, Spertus JA, Costa F. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735-52. 

  14. van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB. Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care. 2002;25(3):417-24. 

  15. Alipour A, Elte JWF, van Zaanen HCT, Rietveld AP, Cabezas MC. Postprandial inflammation and endothelial dysfuction. Biochem Soc Trans. 2007;35(Pt 3):466-9. 

  16. Wallace JP, Johnson B, Padilla J, Mather K. Postprandial lipaemia, oxidative stress and endothelial function: a review. Int J Clin Pract. 2010;64(3):389-403. 

  17. Lambert JE, Parks EJ. Postprandial metabolism of meal triglyceride in humans. Biochim Biophys Acta. 2012;1821(5):721-6. 

  18. Ghosh A, Gao L, Thakur A, Siu PM, Lai CWK. Role of free fatty acids in endothelial dysfunction. J Biomed Sci. 2017;24(1):50. 

  19. de Munter W, Blom AB, Helsen MM, Walgreen B, van der Kraan PM, Joosten LAB, van den Berg WB, van Lent PLEM. Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis. Arthritis Res Ther. 2013;15(6):R178. 

  20. de Munter W, van der Kraan PM, van den Berg WB, van Lent PLEM. High systemic levels of low-density lipoprotein cholesterol: fuel to the flames in inflammatory osteoarthritis? Rheumatol Oxf Engl. 2016;55(1):16-24. 

  21. Chung S, Parks JS. Dietary cholesterol effects on adipose tissue inflammation. Curr Opin Lipidol. 2016;27(1):19-25. 

  22. Hu P, Bao J, Wu L. The emerging role of adipokines in osteoarthritis: a narrative review. Mol Biol Rep. 2011;38(2):873-8. 

  23. Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, Mainard D, Netter P, Terlain B. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage. 2006;14(7):690-5. 

  24. de Boer TN, van Spil WE, Huisman AM, Polak AA, Bijlsma JWJ, Lafeber FPJG, Mastbergen SC. Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthritis Cartilage. 2012;20(8):846-53. 

  25. Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, Pottie P. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 2003;48(11):3118-29. 

  26. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003; 423(6941):762-9. 

  27. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86(5):1930-5. 

  28. Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, Kumar S, Invitti C. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis. 2006;189(2):401-7. 

  29. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez-Reino JJ, Gualillo O. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65(9):1198-201. 

  30. Chen TH, Chen L, Hsieh MS, Chang CP, Chou DT, Tsai SH. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta. 2006;1762(8): 711-8. 

  31. Unger RH. Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine. Biochimie. 2005;87(1):57-64. 

  32. Larralaga-Vera A, Lamuedra A, Prez-Baos S, Prieto-Potin I, Pena L, Herrero-Beaumont G, Largo R. Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis. Arthritis Res Ther. 2017;19(1):264. 

  33. Collins KH, Reimer RA, Seerattan RA, Leonard TR, Herzog W. Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats. Osteoarthritis Cartilage. 2015;23(6):957-65. 

  34. Willson TM, Lambert MH, Kliewer SA. Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem. 2001;70:341-67. 

  35. Kim HI, Ahn YH. Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells. Diabetes. 2004;53 Suppl 1:S60-5. 

  36. Shimazaki N, Togashi N, Hanai M, Isoyama T, Wada K, Fujita T, Fujiwara K, Kurakata S. Anti-tumour activity of CS-7017, a selective peroxisome proliferator-activated receptor gamma agonist of thiazolidinedione class, in human tumour xenografts and a syngeneic tumour implant model. Eur J Cancer Oxf Engl 1990. 2008;44(12):1734-43. 

  37. Smallridge RC, Copland JA, Brose MS, Wadsworth T, Houvras Y, Menefee ME, Bible KC, Shah MH, Gramza AW, Klopper JP, Marlow LA, Heckman MG, von Roemeling R. Efatutazone, an oral PPAR-γ agonist, in combination with paclitaxel in anaplastic thyroid cancer: results of a multicenter phase 1 trial. J Clin Endocrinol Metab. 2013;98(6):2392-400. 

  38. Serizawa M, Murakami H, Watanabe M, Takahashi T, Yamamoto N, Koh Y. Peroxisome proliferator-activated receptor γ agonist efatutazone impairs transforming growth factor β2-induced motility of epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer cells. Cancer Sci. 2014;105(6):683-9. 

  39. Toth PP, Simko RJ, Palli SR, Koselleck D, Quimbo RA, Cziraky MJ. The impact of serum lipids on risk for microangiopathy in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2012;11:109. 

  40. Kontush A, Chapman MJ. Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities. Curr Opin Lipidol. 2010;21(4):312-8. 

  41. Gylling H, Plat J, Turley S, Ginsberg HN, Ellegard L, Jessup W, Jones PJ, Lutjohann D, Maerz W, Masana L, Silbernagel G, Staels B, Boren J, Catapano AL, de Backer G, Deanfield J, Descamps OS, Kovanen PT, Riccardi G, Tokgozoglu L, Chapman MJ. Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis. 2014;232(2):346-60. 

  42. Jacobson TA. Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgia. Mayo Clin Proc. 2008;83(6):687-700. 

  43. Aiman U, Najmi A, Khan RA. Statin induced diabetes and its clinical implications. J Pharmacol Pharmacother. 2014;5(3):181-5. 

  44. Leutner M, Matzhold C, Bellach L, Deischinger C, Harreiter J, Thurner S, Klimek P, Kautzky-Willer A. Diagnosis of osteoporosis in statin-treated patients is dose-dependent. Annals of the Rheumatic Diseases. 2019;78:1706-11. 

  45. Lee W. Medical dictionary. Department of Pharmacology, Yonsei University. 5th ed. Paju:Gunja Publishing. 2012. 

  46. Pastori D, Pignatelli P, Farcomeni A, Nocella C, Bartimoccia S, Carnevale R, Violi F. Age-related increase of thromboxane B 2 and risk of cardiovascular disease in atrial fibrillation. Oncotarget. 2016;7(26): 39143-7. 

  47. Smyth EM. Thromboxane and the thromboxane receptor in cardiovascular disease. Clin Lipidol. 2010;5(2):209-19. 

  48. Fontana P, Zufferey A, Daali Y, Reny JL. Antiplatelet therapy: targeting the TxA2 pathway. J Cardiovasc Transl Res. 2014;7(1):29-38. 

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