$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

An Impaired Inflammatory and Innate Immune Response in COVID-19 원문보기

Molecules and cells, v.44 no.6, 2021년, pp.384 - 391  

Park, Sung Ho (Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST))

Abstract AI-Helper 아이콘AI-Helper

The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse out...

주제어

참고문헌 (67)

  1. Abers M.S. Delmonte O.M. Ricotta E.E. Fintzi J. Fink D.L. de Jesus A.A.A. Zarember K.A. Alehashemi S. Oikonomou V. Desai J.V. 2021 An immune-based biomarker signature is associated with mortality in COVID-19 patients JCI Insight 6 e144455 10.1172/jci.insight.144455 33232303 

  2. Arunachalam P.S. Wimmers F. Mok C.K.P. Perera R. Scott M. Hagan T. Sigal N. Feng Y. Bristow L. Tak-Yin Tsang O. 2020 Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans Science 369 1210 1220 10.1126/science.abc6261 32788292 

  3. Bastard P. Rosen L.B. Zhang Q. Michailidis E. Hoffmann H.H. Zhang Y. Dorgham K. Philippot Q. Rosain J. Beziat V. 2020 Autoantibodies against type I IFNs in patients with life-threatening COVID-19 Science 370 eabd4585 10.1126/science.abd4585 32972996 

  4. Bernardes J.P. Mishra N. Tran F. Bahmer T. Best L. Blase J.I. Bordoni D. Franzenburg J. Geisen U. Josephs-Spaulding J. 2020 Longitudinal multi-omics analyses identify responses of megakaryocytes, erythroid cells, and plasmablasts as hallmarks of severe COVID-19 Immunity 53 1296 1314.e9 10.1016/j.immuni.2020.11.017 33296687 

  5. Blanco-Melo D. Nilsson-Payant B.E. Liu W.C. Uhl S. Hoagland D. Moller R. Jordan T.X. Oishi K. Panis M. Sachs D. 2020 Imbalanced host response to SARS-CoV-2 drives development of COVID-19 Cell 181 1036 1045.e9 10.1016/j.cell.2020.04.026 32416070 

  6. Bost P. Giladi A. Liu Y. Bendjelal Y. Xu G. David E. Blecher-Gonen R. Cohen M. Medaglia C. Li H. 2020 Host-viral infection maps reveal signatures of severe COVID-19 patients Cell 181 1475 1488.e12 10.1016/j.cell.2020.05.006 32479746 

  7. Brodin P. 2021 Immune determinants of COVID-19 disease presentation and severity Nat. Med. 27 28 33 10.1038/s41591-020-01202-8 33442016 

  8. Brunetta E. Folci M. Bottazzi B. De Santis M. Gritti G. Protti A. Mapelli S.N. Bonovas S. Piovani D. Leone R. 2021 Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 Nat. Immunol. 22 19 24 10.1038/s41590-020-00832-x 33208929 

  9. Cameron M.J. Ran L. Xu L. Danesh A. Bermejo-Martin J.F. Cameron C.M. Muller M.P. Gold W.L. Richardson S.E. Poutanen S.M. 2007 Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome J. Virol. 81 8692 8706 10.1128/JVI.00527-07 17537853 

  10. Carvelli J. Demaria O. Vely F. Batista L. Chouaki Benmansour N. Fares J. Carpentier S. Thibult M.L. Morel A. Remark R. 2020 Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis Nature 588 146 150 10.1038/s41586-020-2600-6 32726800 

  11. Channappanavar R. Fehr A.R. Zheng J. Wohlford-Lenane C. Abrahante J.E. Mack M. Sompallae R. McCray P.B. Jr. Meyerholz D.K. Jr. Perlman S. Jr. 2019 IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes J. Clin. Invest. 129 3625 3639 10.1172/JCI126363 31355779 

  12. Chen J. Ivashkiv L.B. 2010 IFN-gamma abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling Proc. Natl. Acad. Sci. U. S. A. 107 19438 19443 20974955 

  13. Cho D.H. Kim J.K. Jo E.K. 2020 Mitophagy and innate immunity in infection Mol. Cells 43 10 22 10.14348/molcells.2020.2329 31999918 

  14. Chua R.L. Lukassen S. Trump S. Hennig B.P. Wendisch D. Pott F. Debnath O. Thurmann L. Kurth F. Volker M.T. 2020 COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis Nat. Biotechnol. 38 970 979 10.1038/s41587-020-0602-4 32591762 

  15. Combes A.J. Courau T. Kuhn N.F. Hu K.H. Ray A. Chen W.S. Chew N.W. Cleary S.J. Kushnoor D. Reeder G.C. 2021 Global absence and targeting of protective immune states in severe COVID-19 Nature 591 124 130 10.1038/s41586-021-03234-7 33494096 

  16. Consiglio C.R. Cotugno N. Sardh F. Pou C. Amodio D. Rodriguez L. Tan Z. Zicari S. Ruggiero A. Pascucci G.R. 2020 The immunology of multisystem inflammatory syndrome in children with COVID-19 Cell 183 968 981.e7 10.1016/j.cell.2020.09.016 32966765 

  17. Del Valle D.M. Kim-Schulze S. Huang H.H. Beckmann N.D. Nirenberg S. Wang B. Lavin Y. Swartz T.H. Madduri D. Stock A. 2020 An inflammatory cytokine signature predicts COVID-19 severity and survival Nat. Med. 26 1636 1643 10.1038/s41591-020-1051-9 32839624 

  18. Fajgenbaum D.C. June C.H. 2020 Cytokine storm N. Engl. J. Med. 383 2255 2273 10.1056/NEJMra2026131 33264547 

  19. Galani I.E. Rovina N. Lampropoulou V. Triantafyllia V. Manioudaki M. Pavlos E. Koukaki E. Fragkou P.C. Panou V. Rapti V. 2021 Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison Nat. Immunol. 22 32 40 10.1038/s41590-020-00840-x 33277638 

  20. Giamarellos-Bourboulis E.J. Netea M.G. Rovina N. Akinosoglou K. Antoniadou A. Antonakos N. Damoraki G. Gkavogianni T. Adami M.E. Katsaounou P. 2020 Complex immune dysregulation in COVID-19 patients with severe respiratory failure Cell Host Microbe 27 992 1000.e3 10.1016/j.chom.2020.04.009 32320677 

  21. Giroux N.S. Ding S. McClain M.T. Burke T.W. Petzold E. Chung H.A. Palomino G.R. Wang E. Xi R. Bose S. 2020 Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity BioRxiv https://doi.org/10.1101/2020.12.04.412155 10.1101/2020.12.04.412155 33300002 

  22. Grant R.A. Morales-Nebreda L. Markov N.S. Swaminathan S. Querrey M. Guzman E.R. Abbott D.A. Donnelly H.K. Donayre A. Goldberg I.A. 2021 Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia Nature 590 635 641 10.1038/s41586-020-03148-w 33429418 

  23. Hadjadj J. Yatim N. Barnabei L. Corneau A. Boussier J. Smith N. Pere H. Charbit B. Bondet V. Chenevier-Gobeaux C. 2020 Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Science 369 718 724 10.1126/science.abc6027 32661059 

  24. Ivashkiv L.B. 2018 IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy Nat. Rev. Immunol. 18 545 558 29921905 

  25. Ivashkiv L.B. Donlin L.T. 2014 Regulation of type I interferon responses Nat. Rev. Immunol. 14 36 49 10.1038/nri3581 24362405 

  26. Kapellos T.S. Bonaguro L. Gemund I. Reusch N. Saglam A. Hinkley E.R. Schultze J.L. 2019 Human monocyte subsets and phenotypes in major chronic inflammatory diseases Front. Immunol. 10 2035 10.3389/fimmu.2019.02035 31543877 

  27. Karki R. Sharma B.R. Tuladhar S. Williams E.P. Zalduondo L. Samir P. Zheng M. Sundaram B. Banoth B. Malireddi R.K.S. 2021 Synergism of TNF-alpha and IFN-gamma triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes Cell 184 149 168.e17 33278357 

  28. King C. Sprent J. 2021 Dual nature of type I interferons in SARS-CoV-2-induced inflammation Trends Immunol. 42 312 322 10.1016/j.it.2021.02.003 33622601 

  29. Laing A.G. Lorenc A. Del Molino Del Barrio I. Das A. Fish M. Monin L. Munoz-Ruiz M. McKenzie D.R. Hayday T.S. Francos-Quijorna I. 2020 A dynamic COVID-19 immune signature includes associations with poor prognosis Nat. Med. 26 1623 1635 10.1038/s41591-020-1038-6 32807934 

  30. Lee J.S. Park S. Jeong H.W. Ahn J.Y. Choi S.J. Lee H. Choi B. Nam S.K. Sa M. Kwon J.S. 2020 Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 Sci. Immunol. 5 eabd1554 10.1126/sciimmunol.abd1554 32651212 

  31. Liao M. Liu Y. Yuan J. Wen Y. Xu G. Zhao J. Cheng L. Li J. Wang X. Wang F. 2020 Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 Nat. Med. 26 842 844 10.1038/s41591-020-0901-9 32398875 

  32. Lucas C. Wong P. Klein J. Castro T.B.R. Silva J. Sundaram M. Ellingson M.K. Mao T. Oh J.E. Israelow B. 2020 Longitudinal analyses reveal immunological misfiring in severe COVID-19 Nature 584 463 469 10.1038/s41586-020-2588-y 32717743 

  33. Mann E.R. Menon M. Knight S.B. Konkel J.E. Jagger C. Shaw T.N. Krishnan S. Rattray M. Ustianowski A. Bakerly N.D. 2020 Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19 Sci. Immunol. 5 eabd6197 10.1126/sciimmunol.abd6197 32943497 

  34. McNab F. Mayer-Barber K. Sher A. Wack A. O'Garra A. 2015 Type I interferons in infectious disease Nat. Rev. Immunol. 15 87 103 10.1038/nri3787 25614319 

  35. Merad M. Martin J.C. 2020 Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages Nat. Rev. Immunol. 20 355 362 10.1038/s41577-020-0331-4 32376901 

  36. Middleton E.A. He X.Y. Denorme F. Campbell R.A. Ng D. Salvatore S.P. Mostyka M. Baxter-Stoltzfus A. Borczuk A.C. Loda M. 2020 Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome Blood 136 1169 1179 10.1182/blood.2020007008 32597954 

  37. Netea M.G. Giamarellos-Bourboulis E.J. Dominguez-Andres J. Curtis N. van Crevel R. van de Veerdonk F.L. Bonten M. 2020 Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection Cell 181 969 977 10.1016/j.cell.2020.04.042 32437659 

  38. Nie X. Qian L. Sun R. Huang B. Dong X. Xiao Q. Zhang Q. Lu T. Yue L. Chen S. 2021 Multi-organ proteomic landscape of COVID-19 autopsies Cell 184 775 791.e14 10.1016/j.cell.2021.01.004 33503446 

  39. Park A. Iwasaki A. 2020 Type I and type III interferons - induction, signaling, evasion, and application to combat COVID-19 Cell Host Microbe 27 870 878 10.1016/j.chom.2020.05.008 32464097 

  40. Park S.H. Kang K. Giannopoulou E. Qiao Y. Kang K. Kim G. Park-Min K.H. Ivashkiv L.B. 2017 Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation Nat. Immunol. 18 1104 1116 10.1038/ni.3818 28825701 

  41. Platanitis E. Decker T. 2018 Regulatory networks involving STATs, IRFs, and NFkappaB in inflammation Front. Immunol. 9 2542 30483250 

  42. Radermecker C. Detrembleur N. Guiot J. Cavalier E. Henket M. d'Emal C. Vanwinge C. Cataldo D. Oury C. Delvenne P. 2020 Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 J. Exp. Med. 217 e20201012 10.1084/jem.20201012 32926097 

  43. Ramlall V. Thangaraj P.M. Meydan C. Foox J. Butler D. Kim J. May B. De Freitas J.K. Glicksberg B.S. Mason C.E. 2020 Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection Nat. Med. 26 1609 1615 10.1038/s41591-020-1021-2 32747830 

  44. Horby P. Lim W.S. Emberson J.R. Mafham M. Bell J.L. Linsell L. Staplin N. Brightling C. Ustianowski A. RECOVERY Collaborative Group 2021 Dexamethasone in hospitalized patients with Covid-19 N. Engl. J. Med. 384 693 704 10.1056/NEJMoa2021436 32678530 

  45. Ren X. Wen W. Fan X. Hou W. Su B. Cai P. Li J. Liu Y. Tang F. Zhang F. 2021 COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas Cell 184 1895 1913.e19 10.1016/j.cell.2021.01.053 33657410 

  46. Rodrigues T.S. de Sa K.S.G. Ishimoto A.Y. Becerra A. Oliveira S. Almeida L. Goncalves A.V. Perucello D.B. Andrade W.A. Castro R. 2021 Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients J. Exp. Med. 218 e20201707 10.1084/jem.20201707 33231615 

  47. Schoggins J.W. Rice C.M. 2011 Interferon-stimulated genes and their antiviral effector functions Curr. Opin. Virol. 1 519 525 10.1016/j.coviro.2011.10.008 22328912 

  48. Schulte-Schrepping J. Reusch N. Paclik D. Bassler K. Schlickeiser S. Zhang B. Kramer B. Krammer T. Brumhard S. Bonaguro L. 2020 Severe COVID-19 is marked by a dysregulated myeloid cell compartment Cell 182 1419 1440.e23 10.1016/j.cell.2020.08.001 32810438 

  49. Sheahan T. Morrison T.E. Funkhouser W. Uematsu S. Akira S. Baric R.S. Heise M.T. 2008 MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV PLoS Pathog. 4 e1000240 10.1371/journal.ppat.1000240 19079579 

  50. Shen B. Yi X. Sun Y. Bi X. Du J. Zhang C. Quan S. Zhang F. Sun R. Qian L. 2020 Proteomic and metabolomic characterization of COVID-19 patient sera Cell 182 59 72.e15 10.1016/j.cell.2020.05.032 32492406 

  51. Shi L. Zhang Z. Yu A.M. Wang W. Wei Z. Akhter E. Maurer K. Costa Reis P. Song L. Petri M. 2014 The SLE transcriptome exhibits evidence of chronic endotoxin exposure and has widespread dysregulation of non-coding and coding RNAs PLoS One 9 e93846 10.1371/journal.pone.0093846 24796678 

  52. Shin D. Mukherjee R. Grewe D. Bojkova D. Baek K. Bhattacharya A. Schulz L. Widera M. Mehdipour A.R. Tascher G. 2020 Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity Nature 587 657 662 10.1038/s41586-020-2601-5 32726803 

  53. Silvin A. Chapuis N. Dunsmore G. Goubet A.G. Dubuisson A. Derosa L. Almire C. Henon C. Kosmider O. Droin N. 2020 Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19 Cell 182 1401 1418.e18 10.1016/j.cell.2020.08.002 32810439 

  54. Sokol C.L. Luster A.D. 2015 The chemokine system in innate immunity Cold Spring Harb. Perspect. Biol. 7 a016303 10.1101/cshperspect.a016303 25635046 

  55. Su Y. Chen D. Yuan D. Lausted C. Choi J. Dai C.L. Voillet V. Duvvuri V.R. Scherler K. Troisch P. 2020 Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19 Cell 183 1479 1495.e20 10.1016/j.cell.2020.10.037 33171100 

  56. Totura A.L. Whitmore A. Agnihothram S. Schafer A. Katze M.G. Heise M.T. Baric R.S. 2015 Toll-like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection Bio 6 e00638 15 10.1128/mBio.00638-15 26015500 

  57. Vabret N. Britton G.J. Gruber C. Hegde S. Kim J. Kuksin M. Levantovsky R. Malle L. Moreira A. Park M.D. 2020 Immunology of COVID-19: current state of the science Immunity 52 910 941 10.1016/j.immuni.2020.05.002 32505227 

  58. van der Poll T. van de Veerdonk F.L. Scicluna B.P. Netea M.G. 2017 The immunopathology of sepsis and potential therapeutic targets Nat. Rev. Immunol. 17 407 420 10.1038/nri.2017.36 28436424 

  59. Venkatesh D. Ernandez T. Rosetti F. Batal I. Cullere X. Luscinskas F.W. Zhang Y. Stavrakis G. Garcia-Cardena G. Horwitz B.H. 2013 Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-beta autocrine signaling to promote monocyte recruitment Immunity 38 1025 1037 10.1016/j.immuni.2013.01.012 23623383 

  60. Wang N. Zhan Y. Zhu L. Hou Z. Liu F. Song P. Qiu F. Wang X. Zou X. Wan D. 2020 Retrospective multicenter cohort study shows early interferon therapy is associated with favorable clinical responses in COVID-19 patients Cell Host Microbe 28 455 464.e2 10.1016/j.chom.2020.07.005 32707096 

  61. Wei J. Alfajaro M.M. DeWeirdt P.C. Hanna R.E. Lu-Culligan W.J. Cai W.L. Strine M.S. Zhang S.M. Graziano V.R. Schmitz C.O. 2021 Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection Cell 184 76 91.e13 10.1016/j.cell.2020.10.028 33147444 

  62. Wilk A.J. Rustagi A. Zhao N.Q. Roque J. Martinez-Colon G.J. McKechnie J.L. Ivison G.T. Ranganath T. Vergara R. Hollis T. 2020 A single-cell atlas of the peripheral immune response in patients with severe COVID-19 Nat. Med. 26 1070 1076 10.1038/s41591-020-0944-y 32514174 

  63. Yarilina A. Park-Min K.H. Antoniv T. Hu X. Ivashkiv L.B. 2008 TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes Nat. Immunol. 9 378 387 10.1038/ni1576 18345002 

  64. Zhang Q. Bastard P. Liu Z. Le Pen J. Moncada-Velez M. Chen J. Ogishi M. Sabli I.K.D. Hodeib S. Korol C. 2020 Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 Science 370 eabd4570 10.1126/science.abd4570 32972995 

  65. Zhou R. To K.K. Wong Y.C. Liu L. Zhou B. Li X. Huang H. Mo Y. Luk T.Y. Lau T.T. 2020a Acute SARS-CoV-2 infection impairs dendritic cell and T cell responses Immunity 53 864 877.e5 10.1016/j.immuni.2020.07.026 32791036 

  66. Zhou Z. Ren L. Zhang L. Zhong J. Xiao Y. Jia Z. Guo L. Yang J. Wang C. Jiang S. 2020b Heightened innate immune responses in the respiratory tract of COVID-19 patients Cell Host Microbe 27 883 890.e2 10.1016/j.chom.2020.04.017 32407669 

  67. Zhu L. Yang P. Zhao Y. Zhuang Z. Wang Z. Song R. Zhang J. Liu C. Gao Q. Xu Q. 2020 Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients Immunity 53 685 696.e3 10.1016/j.immuni.2020.07.009 32783921 

관련 콘텐츠

원문 보기

원문 URL 링크

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로