[논문]Iopamidol과 Ioversol 제제 조영제의 사용 후 보관 기간에 따른 1H-NMR 분석

한범희

doi:10.17946/jrst.2021.44.3.239

Iopamidol과 Ioversol 제제 조영제의 사용 후 보관 기간에 따른 1H-NMR 분석
1H-NMR Analysis according to the Storage Period after the Use of Iopamidol and Ioversol Formulations Contrast Agents 원문보기

방사선기술과학 = Journal of radiological science and technology, v.44 no.3, 2021년, pp.239 - 245

한범희 (방사선과학기술연구소 연구개발팀)

Abstract ▼ AI-Helper

Since the side effects of contrast agents occur in many ways, hospitals must clearly identify the contrast agents and know how to manage them. Storage of contrast media It is common practice to store contrast media in a warm room to reduce viscosity and improve patient comfort. However, it is important to recognize that long-term storage at high temperatures can shorten the shelf life of a product. Therefore, in this study, the presence or absence of chemical changes according to the storage period after using the contrast medium was analyzed. As the analysis equipment, a 500 MHz Nuclear Magnetic Resonance Spectrometer of Bruker Avance (Germany) possessed by Korea Basic Science Institute (KOREA BASIC SCIENCE INSTITUTE; KBSI) was used. For the X-ray iodide contrast medium, Pamiray contrast medium of Iopamidol and Optiray contrast medium of Ioversol, samples remaining after 7 days, 20 days, 30 days, and 1 year were collected, By acquiring the spectrum from the 1H-NMR spectrometer of the contrast medium stimulated by It was compared and analyzed with the standard sample. In conclusion, depending on the storage period of the contrast medium, no peaks of physical and chemical changes were observed in both the Pamiray contrast medium of Iopamidol and the Optiray contrast medium of Ioversol after 7 days, 20 days, 30 days, and 1 year after use.

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Iopamidol과 Ioversol 제제 조영제의 사용 후 보관 기간에 따른 1H-NMR 분석
1H-NMR Analysis according to the Storage Period after the Use of Iopamidol and Ioversol Formulations Contrast Agents 원문보기

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Iopamidol과 Ioversol 제제 조영제의 사용 후 보관 기간에 따른 1H-NMR 분석 1H-NMR Analysis according to the Storage Period after the Use of Iopamidol and Ioversol Formulations Contrast Agents 원문보기

Abstract ▼ AI-Helper

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Iopamidol과 Ioversol 제제 조영제의 사용 후 보관 기간에 따른 1H-NMR 분석
1H-NMR Analysis according to the Storage Period after the Use of Iopamidol and Ioversol Formulations Contrast Agents 원문보기