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Journal of microbiology and biotechnology, v.31 no.6, 2021년, pp.867 - 874
Lingappa, Sivakumar (Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University) , Shivakumar, Muthugounder Subramanian (Molecular Entomology Lab, Department of Biotechnology, Periyar University) , Manivasagam, Thamilarasan (Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University) , Somasundaram, Somasundaram Thirugnanasambandan (Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University) , Seedevi, Palaniappan (Department of Environmental Science, Periyar University)
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Epalrestat (EPS) is a brain penetrant aldose reductase inhibitor, an approved drug currently used for the treatment of diabetic neuropathy. At near-plasma concentration, EPS induces glutathione biosynthesis, which in turn reduces oxidative stress in the neuronal cells. In this study, we found that E...
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