[논문]상기도 감염 환자의 amoxicillin 대비 한약의 효과에 대한 체계적 문헌고찰 : PubMED를 중심으로

곽승연; 정설; 조은지; 정의민

doi:10.6116/kjh.2021.36.5.37.

상기도 감염 환자의 amoxicillin 대비 한약의 효과에 대한 체계적 문헌고찰 : PubMED를 중심으로
Systematic Review on the Effects of Herbal Medicine Compared to Amoxicillin in Patients with Upper Respiratory Tract Infection : Focusing on PubMED 원문보기

大韓本草學會誌 = The Korea journal of herbology, v.36 no.5, 2021년, pp.37 - 46

곽승연 (상지대학교 한의과대학) , 정설 (상지대학교 한의과대학) , 조은지 (상지대학교 한의과대학) , 정의민 (상지대학교 한의과대학 내과학교실)

Abstract ▼ AI-Helper

Objective : This study aims to examine the effectiveness and safety of herbal medicines in upper respiratory tract infection by conducting systematic review against amoxicillin. Methods : Relevant randomized controlled trials (RCTs) published by December 2020 were searched in PubMED database. Study selection was conducted according to the PRISMA guideline. The Risk of Bias of the RCTs were evaluated based on the Cochrane criteria. Study selection and bias assessment were conducted independently by two researchers, and the third party was involved if there is a disagreement. Results : Three RCTs were included. Meta-analysis was not performed due to different specific disease and outcome measurements among the included studies. Herbal medicine showed statistically significant improvement in symptoms and endoscopic findings compared to amoxicillin in acute rhinosinusitis. In addition, herbal medicine showed statistically significant improvement in symptoms and a smaller dose of additional antibiotics in acute tonsillitis. However, herbal medicine showed no significant effects compared to amoxicillin in chronic sinusitis patients after functional endoscopic sinus surgery. In terms of adverse events, no significant difference was observed between the herbal medicine group and the amoxicillin group in all studies. Conclusion : Herbal medicine might be more effective than amoxicillin in the treatment of upper respiratory tract infection. Nevertheless, it is hard to clear that conclusion due to the fact that the collected studies were conducted on different specific diseases and herbal medicine, and that the included studies had flaws in the research methodology.

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표/그림 (4)

그림 Fig 1. PRISMA (Preferred reporting items for systematic reviews and meta-analysis) flow diagram for effect comparison of herbal medicine and synthetic drugs including amoxicillin for upper respiratory tract infection. n : number
그림 Fig 2. Risk of bias summary. +: low risk of bias; -: high risk of bias, ?: unclear risk of bias.
표 Table 1. Composition of intervention herb.
표 Table 2. Characteristics of Included Randomized Clinical Trials.

참고문헌 (54)

Kim SW. Upper respiratory infections in adults. Journal of the Korean Medical Association. 2010 ; 53 (1) : 10-9.

상세보기
Thomas M, Bomar PA. Upper Respiratory Tract Infection. [Updated 2020 Oct 28]. In : StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing ; 2021 Jan-. Available from : URL : https://www.ncbi.nlm.nih.gov/books/NBK532961/
Tang J, Chen J, He T, Jiang Z, Zhou J, Hu B, et al. Diversity of upper respiratory tract infections and prevalence of Streptococcus pneumoniae colonization among patients with fever and flu-like symptoms. BMC Infect Dis. 2019 ; 19(1) : 24.

상세보기
Choi WJ, Yim ES, Kim TH, Suh HS, Choi KC, Jeong UJ. Analysis of Factors Related to the Prescription of Antibiotics for the Acute Upper Respiratory Infection. Health policy and management. 2015 ; 25(4) : 256-63.

원문보기 상세보기
Yoon YK, Park CS, Kim JW, Hwang KR, Lee SY, Kim TH, Park DY, Kim HJ, Kim DY, Lee HJ, Shin HY, You YK, Park DA, Kim SW. Guidelines for the Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections. Korea Centers for Disease Control and Prevention. 2017 : 1-26
Heikkinen T, Jarvinen A. The common cold. The Lancet. 2003 ; 361(9351) : 51-9.

상세보기
Akhavan BJ, Khanna NR, Vijhani P. Amoxicillin. [Updated 2020 Aug 27]. In : StatPearls [Internet]. Treasure Island (FL) : StatPearls Publishing; 2021 Jan-. Available from : URL : https://www.ncbi.nlm.nih.gov/books/NBK482250/
Li YQ, Zhang CH, Zang CP, Gu SY. Clinical study of Chinese Medicine fumigation combined with "Zhuyuan Decoction" in the treatment of chronic rhinosinusitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020 ; 34(1) : 5-9.
Yu JI, Xuan ZY, Ruan Y, Zhang HY, Shi KH, Guo Y. Clinical study on Qinghouyan lozenge in treatment of acute pharyngitis. China journal of Chinese materia medica. 2015 ; 40(2) : 351-5.
Eng YS, Lee CH, Lee WC, Huang CC, Chang JS. Unraveling the Molecular Mechanism of Traditional Chinese Medicine: Formulas Against Acute Airway Viral Infections as Examples. Molecules (Basel, Switzerland). 2019 ; 24(19) : 1-23
He HA, Wang X, Chen YT, Song Z, Zhang BQ. Mechanism of Shengjiang Powder in treating chronic tonsillitis in children based on network pharmacology and molecular docking. China journal of Chinese materia medica. 2021 ; 46(4) : 877-84.
Qi X, Yang M, Ren W, Jia J, Wang J, Han G, Fan D. Find duplicates among the PubMed, EMBASE, and Cochrane Library Databases in systematic review. PLoS One. 2013 ; 8(8) : e71838.

상세보기
Moher D, Tetzlaff J, Tricco AC, Sampson M, Altman DG. Epidemiology and reporting characteristics of systematic reviews. PLoS Med. 2007 ; 4(3) : e78.

상세보기
Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009 ; 6(7) : e100097.

상세보기
Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011] : The Cochrane Collaboration ; 2011. Available from : URL : https://www.riskofbias.info/welcome/rob-2-0-tool#h.p_A3wRibpWRbdy.
Peric A, Gacesa D, Barac A, Sotirovic J, Peric AV. Herbal Drug EPs 7630 versus Amoxicillin in Patients with Uncomplicated Acute Bacterial Rhinosinusitis: A Randomized, Open-Label Study. The Annals of otology, rhinology, and laryngology. 2020 ; 129(10) : 969-76.

상세보기
Liang KL, Su YC, Tsai CC, Lin JS, Jiang RS, Su MC. Postoperative care with Chinese herbal medicine or amoxicillin after functional endoscopic sinus surgery: a randomized, double-blind, placebo-controlled study. American journal of rhinology & allergy. 2011 ; 25(3) : 170-5.

상세보기
Lyu J, Yang C, Wang LX, Xie YM, Yu XQ, Gu L, Gao F, Zhang JX, Yu XK. Randomized double-blind parallel controlled multicenter trial of Reyanning Mixture in treatment of acute tonsillitis. China journal of Chinese materia medica. 2020 ; 45(14) : 3282-91.
Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020 ; 58(Suppl S29) : 1-464.

상세보기
Kim JH, Cho C, Lee EJ, Suh YS, Choi BI, Kim KS. Prevalence and risk factors of chronic rhinosinusitis in South Korea according to diagnostic criteria. Rhinology. 2016 ; 54(4) : 329-35.

상세보기
Wang D, Tian T, Liao C, Liu T, Tang G, Tian L. Effects of houttuynia cordata thunb. on rhinosinusitis by nasal irrigation: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020 ; 99(51) : e23634.

상세보기
Brendler T, van Wyk BE. A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). Journal of ethnopharmacology. 2008 ; 119(3) : 420-33.

상세보기
Lizogub VG, Riley DS, Heger M. Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. Explore. 2007 ; 3(6) : 573-84.

상세보기
Schapowal A, Heger M. EPs® 7630 Losung (Umckaloabo®) bei Sinusitis. Zeitschrift fur Phytotherapie. 2007 ; 28(02) : 58-65.
Heil C, Reitermann U. Atemwegs-und HNO-Infektionen: Therapeutische erfahrungen mit dem phytotherapeutikum Umckaloabo®. Therapiewoche Padiatrie. 1994 ; 7 : 523-5.
Timmer A, Gunther J, Motschall E, Rucker G, Antes G, Kern WV. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database of Systematic Reviews. 2013(10) : CD006323.
van Cauwenberge P, Ingels K. Effects of viral and bacterial infection on nasal and sinus mucosa. Acta Otolaryngol. 1996 ; 116(2) : 316-21.

상세보기
Uslu H, Yoruk O, Ayyildiz A, Aktan B. Antibacterial spectrum of Umckaloabo (Pelargonium sidoides) on upper airway infection agents. Eur J Gen Med. 2009 ; 6 : 245-8.
Wang YQ, Meng QL, Wei SH. cang er san zhi liao bi xi rou xiao yi. Liaoning Journal of traditional Chinese Medicine. 1982(12) : 33.
Tan ZL, Zhang YJ. cang er san jia jian zhi liao man xing bi yan 63 li. Journal of practical Chinese Medicine. 2008(06) : 360.
Lu YQ. Modified Cang'er Powder for Sinusitis lu you qiang. Shaanxi Journal of Traditional Chinese Medicine. 2004(06) : 521-2.
Le DF, Gao X. cang er san jia wei zhi liao fu bi zuo yan de ji dian ti hui. Chinese Community Doctors. 1996(09) : 29.
Zhao GC, Ren LJ. cang er san jia wei zhi liao bi zuo yan 20 li. Jilin Journal of Traditional Chinese Medicine. 1992(04) : 32.
Li YY, Cai YM, Zhang YL, Jiang CF, Zheng CF. cang er san jia wei zhi liao bi dou yan. Family Medicine. 1996(24) : 44.
Wang XR, He J, Li, XM, Wang WH, Xie GM. xin ding cang er san zhi liao bi zuo yan liao xiao guan cha. Traditional Chinese Medicine. 1992(06) : 285-6.
Hu C, Li H, Wu L, Xiong Y. Mechanism of Cang'er Powder in Treatment of Rhinitis Based on Network Pharmacology. Chinese Archives of Traditional Chinese Medicine. 2020 ; 38(10) : 64-71.
Chen H, Yang C, Ke T, Zhou M, Li Z, Zhang M, Gong G, Hou T. Antimicrobial activity of secondary metabolites from Streptomyces sp. K15, an endophyte in Houttuynia cordata Thunb. Natural product research. 2015 ; 29(23) : 2223-5.

상세보기
Hayashi K, Kamiya M, Hayashi T. Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV. Planta medica. 1995 ; 61(03) : 237-41.

상세보기
You Xj, Fang Jg, Liu Z, Zhen HT, Gao QX, Cui YH, Tao YLl. The clinical effect of Yuxingcao nasal drops to acute and chronic rhinitis. Herald Med. 2007 ; 11 : 1310-3.
Shingnaisui K, Dey T, Manna P, Kalita J. Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review. Journal of ethnopharmacology. 2018 ; 220 : 35-43.

상세보기
Jiang RS, Liang KL, Yang KY, Shiao JY, Su MC, Hsin CH, Lin JF. Postoperative antibiotic care after functional endoscopic sinus surgery. American journal of rhinology. 2008 ; 22(6) : 608-12.

상세보기
Benninger MS, Ferguson BJ, Hadley JA, Hamilos DL, Jacobs M, Kennedy DW, Lanza DC, Marple BF, Osguthorpe JD, Stankiewicz JA. Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngology-Head and Neck Surgery. 2003 ; 129(3) : S1-S32.

상세보기
Albu S, Lucaciu R. Prophylactic antibiotics in endoscopic sinus surgery: a short follow-up study. American journal of rhinology & allergy. 2010 ; 24(4) : 306-9.

상세보기
Doug S, Nina LS. Acute Tonsillitis. Infectious Disorders - Drug Targets. 2012 ; 12(4) : 271-6.

상세보기
Fan CZ, Miao Q, Zhang Q, Fan MR, Liao X, Liu J, Li PH, Cong XD, Wang B. Advantages and evidence of Chinese medicine in prevention and treatment of adult acute tonsillitis. China journal of Chinese materia medica. 2017 ; 42(8) : 1430-8.

상세보기
Ma YN, Zhong CL, Hu SY, Cai QH, Guo SX. Evaluation on immediate analgesic efficacy and safety of Kai-Hou-Jian spray (children's type) in treating sore throat caused by acute pharyngitis and tonsillitis in children: study protocol for a randomized controlled trial. Trials. 2021 ; 22(1) : 216.

상세보기
Lu R. Experimental study on main pharmacodynamics of Reyanning mixture. Zhejiang Clinical Medical Journal. 2009 ; 11(6) : 568-9.
Wang H, Chu Y, Liu Y, Tian W, Liu D, Zhuang S, Gao M, Li X, Quan X, Ran Z. Multicenter clinical research to treat the acute upper respiratory tract infection in children with Reyanning Mixture. Tianjin Journal of Traditional Chinese Medicine. 2019 ; 36(02) : 141-4.
Yuan J, Hu YX, Lu YR. The clinical research to treat the upper respiratory tract infection in children with Reyanning for 180 cases. Sichuan Medical Journal. 2014(02) : 219-21.
5Fu EQ, Liu W, Sun RL, Nan YD. re yan ning he ji zhi liao gan mao lin chuang guan cha. Journal of Emergency in Traditional Chinese Medicine. 2010(04) : 572-3.
Wang M, Tang ZS, Liu YR, Song ZX, Zhou R, Xu HB, Yu JG, Zhao ML, Zhuo JP. Mechanism Prediction and Anti-virus Compounds Selection of Reyanning Mixture in the Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking Technologie. Modern Chinese Medicine. 2020 ; 22(04) : 484-91.
Yang A, Liu H, Liu F, Fan L, Liao W, Guo J, He K. Study of the Mechanism of the Reyanning Mixture Involved in Treating Novel Coronavirus Pneumonia Based on Network Pharmacology. Natural Product Communications. 2020 ; 15(9) : 1-12
Ting F, Hopkins C. Outcome Measures in Chronic Rhinosinusitis. Curr Otorhinolaryngol Rep. 2018 ; 6(3) : 271-5.

상세보기
Jang EH, Min SY, Kim JH. Review of Clinical Research for Herbal Medicine Treatment on Rhinosinusitis. The Journal of Pediatrics of Korean Medicine. 2018 ; 32(3) : 44-54.

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