[논문]Synergistic Antibacterial Activity of an Active Compound Derived from Sedum takesimense against Methicillin-Resistant Staphylococcus aureus and Its Clinical Isolates

Jeong, Eun-Tak; Park, Seul-Ki; Jo, Du-Min; Khan, Fazlurrahman; Choi, Tae Ho; Yoon, Tae-Mi; Kim, Young-Mog

doi:10.4014/jmb.2105.05015

[국내논문] Synergistic Antibacterial Activity of an Active Compound Derived from Sedum takesimense against Methicillin-Resistant Staphylococcus aureus and Its Clinical Isolates 원문보기

Journal of microbiology and biotechnology, v.31 no.9, 2021년, pp.1288 - 1294

Jeong, Eun-Tak (DYNE SOZE Co., Ltd.) , Park, Seul-Ki (Institute of Food Science, Pukyong National University) , Jo, Du-Min (Department of Food Science and Technology, Pukyong National University) , Khan, Fazlurrahman (Research Center for Marine Integrated Bionics Technology, Pukyong National University) , Choi, Tae Ho (DYNE SOZE Co., Ltd.) , Yoon, Tae-Mi (DYNE SOZE Co., Ltd.) , Kim, Young-Mog (Department of Food Science and Technology, Pukyong National University)

Abstract ▼ AI-Helper

There are a growing number of reports of hospital-acquired infections caused by pathogenic bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA). Many plant products are now being used as a natural means of exploring antimicrobial agents against different types of human pathogenic bacteria. In this research, we sought to isolate and identify an active molecule from Sedum takesimense that has possible antibacterial activity against various clinical isolates of MRSA. NMR analysis revealed that the structure of the HPLC-purified compound was 1,2,4,6-tetra-O-galloyl-glucose. The minimum inhibitory concentration (MIC) of different extract fractions against numerous pathogenic bacteria was determined, and the actively purified compound has potent antibacterial activity against multidrug-resistant pathogenic bacteria, i.e., MRSA and its clinical isolates. In addition, the combination of the active compound and β-lactam antibiotics (e.g., oxacillin) demonstrated synergistic action against MRSA, with a fractional inhibitory concentration (FIC) index of 0.281. The current research revealed an alternative approach to combating pathogenesis caused by multi-drug resistant bacteria using plant materials. Furthermore, using a combination approach in which the active plant-derived compound is combined with antibiotics has proved to be a successful way of destroying pathogens synergistically.

주제어

참고문헌 (35)

1 Ventola CL 2015 The antibiotic resistance crisis: part 1: causes and threats Pharm. Ther. 40 277 283
2 Center for Disease Control (CDC) Antibiotic Resistance Threats in the United States http://www.cdc.gov/drugresistance/threatreport-2013/ Accesed Jan. 23, 2015.
3 Tong SY Davis JS Eichenberger E Holland TL Fowler VG 2015 Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management Clin. Microbiol. Rev. 28 603 661 10.1128/CMR.00134-14 26016486

상세보기
4 Kaur DC Chate SS 2015 Study of antibiotic resistance pattern in methicillin resistant Staphylococcus aureus with special reference to newer antibiotic J. Glob. Infect. Dis. 7 78 84 10.4103/0974-777X.157245 26069428

상세보기
5 French GL 2010 The continuing crisis in antibiotic resistance Int. J. Antimicrob. Agents 36 S3 S7 10.1016/S0924-8579(10)70003-0

상세보기
6 Pai V Rao VI Rao SP 2010 Prevalence and antimicrobial susceptibility pattern of methicillin-resistant Staphylococcus aureus [MRSA] isolates at a tertiary care hospital in Mangalore, South India J. Lab. Physicians 2 82 84 10.4103/0974-2727.72155 21346902

상세보기
7 Okwu MU Olley M Akpoka AO Izevbuwa OE 2019 Methicillin-resistant Staphylococcus aureus (MRSA) and anti-MRSA activities of extracts of some medicinal plants: a brief review AIMS Microbiol. 5 117 137 10.3934/microbiol.2019.2.117 31384707

상세보기
8 Compean KL Ynalvez RA 2014 Antimicrobial activity of plant secondary metabolites: a review Res. J. Med. Plant. 8 204 213 10.3923/rjmp.2014.204.213

상세보기
9 Sato M Tanaka H Yamaguchi R Kato K Etoh H 2004 Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus Int. J. Antimicrob. Agents 24 241 246 10.1016/j.ijantimicag.2004.03.020 15325427

상세보기
10 Choi JG Kang OH Brice OO Lee YS Chae HS Oh YC 2010 Antibacterial activity of Ecklonia cava against methicillinresistant Staphylococcus aureus and Salmonella spp Foodborne Pathog. Dis. 7 435 441 10.1089/fpd.2009.0434 20001325

상세보기
11 Aqil F Khan MSA Owais M Ahmad I 2005 Effect of certain bioactive plant extracts on clinical isolates of β‐lactamase producing methicillin resistant Staphylococcus aureus J. Basic. Microbiol. 45 106 114 10.1002/jobm.200410355 15812867

상세보기
12 Aqil F Ahmad I Owais M 2006 Evaluation of anti‐methicillin‐resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts Biotechnol. J. 1 1093 1102 10.1002/biot.200600130 17004300

상세보기
13 Cha JD Lee JH Choi KM Choi SM Park JH 2014 Synergistic effect between cryptotanshinone and antibiotics against clinic methicillin and vancomycin-resistant Staphylococcus aureus Evid. Based Complement. Alternat. Med. 2014 450572 10.1155/2014/450572 24782909

상세보기
14 Yoon MY Choi GJ Choi YH Jang KS Park MS Cha B 2010 Effect of polyacetylenic acids from Prunella vulgaris on various plant pathogens Lett. Appl. Microbiol. 51 511 517 10.1111/j.1472-765X.2010.02922.x 20849392

상세보기
15 Yoon MY Choi NH Min BS Choi GJ Choi YH Jang KS 2011 Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii J. Agric. Food. Chem. 59 12210 12216 10.1021/jf2039185 21992072

상세보기
16 Gangadhar M Bhavana P Sunil Y Datta S 2011 Isolation and characterisation of gallic acid from Terminalia bellerica and its effect on carbohydrate regulatory system in vitro Int. J. Res. Ayurveda. Pharm. 2 559 562
17 Hisham DMN Lip JM Noh JM Normah A Nabilah MN 2011 Identification and isolation of methyl gallate as a polar chemical marker for Labisia pumila Benth J. Trop. Agric. Food. Sci. 39 279 284
18 Tanaka T Nonaka GI Nishioka I 1983 7-O-Galloyl-(+)-catechin and 3-O-galloylprocyanidin B-3 from Sanguisorba officinalis Phytochemistry 22 2575 2578 10.1016/0031-9422(83)80168-X

상세보기
19 Tanaka T Nonaka GI Nishioka I 1985 Punicafolin, an ellagitannin from the leaves of Punica grantum Phytochemistry 24 2075 2078 10.1016/S0031-9422(00)83125-8

상세보기
20 Thuong PT Kang JH Na KM Jin YW Youn JU Seong HY 2007 Anti-oxidant constituents from Sedum takesimense Phytochemistry 68 2432 2438 10.1016/j.phytochem.2007.05.031 17658562

상세보기
21 Wang KJ Yang CR Zhang YJ 2007 Phenolic antioxidants from Chinese toon (fresh young leaves and shoots of Toona sinensis ) Food Chem. 101 365 371 10.1016/j.foodchem.2006.01.044

상세보기
22 Xin-Min C Yoshida T Hatano T Fukushima M Okuda T 1987 Galloylarbutin and other polyphenols from Bergenia purpurascens Phytochemistry 26 515 517 10.1016/S0031-9422(00)81446-6

상세보기
23 Yang CM Cheng HY Lin TC Chinag LC Lin CC 2007 The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-D-flucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection J. Ethnopharmacol. 110 555 558 10.1016/j.jep.2006.09.039 17113739

상세보기
24 Yuan GQ Li QQ Qin J 2012 Isolation of methyl gallate from Toxicodendron sylvestre and its effect on tomato bacterial wilt Plant Dis. 96 1143 1147 10.1094/PDIS-03-11-0150-RE 30727051

상세보기
25 Dickson RA Houghton PJ Hyhinds PJ Gibbon S 2006 Antimicrobial, resistance-modifying effects, antioxidant and free radical scavenging activities of Mezoneuron benthamianum Bail., Securinega virosa Roxb. and Wlld. and Microglossa pyrifolia Lam Phytother. Res. 20 41 45 10.1002/ptr.1799 16397919

상세보기
26 Wikler MA 2012 Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard CLSI (NCCLS). 26 M7 A9
27 Norden CW Wentzel H Keleti E 1979 Comparison of techniques for measurement of in vitro antibiotic synergism J. Infect. Dis. 140 629 633 10.1093/infdis/140.4.629 390067

상세보기
28 Yu HH Kim KJ Cha JD Kim HK Lee YE Choi NY 2005 Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus J. Med. Food. 8 454 461 10.1089/jmf.2005.8.454 16379555

상세보기
29 Vu TT Kim JC Choi YH Choi GJ Jang KS Choi TH 2013 Effect of gallotannins derived from Sedum takesimense on tomato bacterial wilt Plant Dis. 97 1593 1598 10.1094/PDIS-04-13-0350-RE 30716836

상세보기
30 Odontuya G 2016 Anti-oxidative, acetylcholinesterase and pancreatic lipase inhibitory activities of compounds from Dasiphora fruticosa Myricaria alopecuroides and Sedum hybridum Mong. J. Chem. 17 42 49 10.5564/mjc.v17i43.746

상세보기
31 Bensouici C Kabouche A Karioti A Öztürk M Duru ME Bilia AR 2016 Compounds from Sedum caeruleum with antioxidant, anticholinesterase, and antibacterial activities Pharm. Biol. 54 174 179 10.3109/13880209.2015.1028078 25845643
32 Lee DS Kang MS Hwang HJ Eom SH Yang JY Lee MS 2008 Synergistic effect between dieckol from Ecklonia stolonifera and β-lactams against methicillin-resistant Staphylococcus aureus Biotechnol. Bioprocess. Eng. 13 758 764 10.1007/s12257-008-0162-9

원문보기 상세보기
33 Lee DS Eom SH Kim YM Kim HS Yim MJ Lee SH 2014 Antibacterial and synergic effects of gallic acid- grafted -chitosan with β-lactams against methicillin-resistant Staphylococcus aureus (MRSA) Can. J. Microbiol. 60 629 638 10.1139/cjm-2014-0286 25216286

상세보기
34 Cantoni LAMJ Wenger A Glauser MP, Bille J 1989 Comparative efficacy of amoxicillin-clavulanate, cloxacillin, and vancomycin against methicillin-sensitive and methicillin-resistant Staphylococcus aureus endocarditis in rats. J. Infect. Dis. 159 989 993 10.1093/infdis/159.5.989 2708846

상세보기
35 Côté H Pichette A Simard F Ouellette ME Ripoll L Mihoub M 2019 Balsacone C, a new antibiotic targeting bacterial cell membranes, inhibits clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) without inducing resistance Front. Microbiol. 10 2341 10.3389/fmicb.2019.02341 31681206

상세보기

LOADING...

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[국내논문] Synergistic Antibacterial Activity of an Active Compound Derived from Sedum takesimense against Methicillin-Resistant Staphylococcus aureus and Its Clinical Isolates 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (35)

이 논문을 인용한 문헌

연구과제 타임라인

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

[국내논문] Synergistic Antibacterial Activity of an Active Compound Derived from Sedum takesimense against Methicillin-Resistant Staphylococcus aureus and Its Clinical Isolates 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (35)

이 논문을 인용한 문헌

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트