[논문]B형 및 C형 간염에 대한 한약 치료의 효과 - 체계적 고찰 연구

김승모; 이유리; 조나경; 최홍식; 김경순

doi:10.22246/jikm.2021.42.4.455

B형 및 C형 간염에 대한 한약 치료의 효과 - 체계적 고찰 연구
Herbal Medicine for the Treatment of Viral Hepatitis B and C: A Systematic Review of Randomized Controlled Trials 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.4, 2021년, pp.455 - 474

김승모 (대구한의대학교 간계내과학교실) , 이유리 (대구한의대학교 간계내과학교실) , 조나경 (대구한의대학교 간계내과학교실) , 최홍식 (대구한의대학교 간계내과학교실) , 김경순 (대구한의대학교 간계내과학교실)

초록
AI-Helper

본 연구는 B형 및 C형 간염에 대한 한약 치료의 효과를 평가하기 위해 무작위 임상연구를 대상으로 체계적 문헌고찰 및 메타분석을 시행하였다. 검색엔진은 EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, Oasis database를 이용하였으며 국내의 검색 엔진 키워드는 '간염' 또는 '바이러스성간염', '한약', '무작위 배정 임상시험'을, 국외 검색 엔진 키워드는 'hepatitis' or 'viral hepatitis' and 'herbal medicine' or 'traditional chinese medicine' and 'randomized controlled trial'을 이용하였다. 연구 결과 15개의 무작위배정 임상시험을 선택되었으며, 그 중 통계적으로 유의미한 결과를 나타낸 연구는 한약과 양약 복합치료군이 양약을 투여한 대조군에 비해 HBV DNA loss에서 높은 효과를 보였다. 한약과 양약 복합치료군이 양약을 투여한 대조군에 비해 HBeAg loss에서 통계적으로 유의한 효과를 보였으며, 한약과 양약 복합치료군이 양약을 투여한 대조군에 비해 ALT가 감소하였다. 본 연구는 B형 및 C형 간염환자를 대상으로 한약의 효과를 확인하기 위해 기존에 시행된 RCT 연구를 대상으로 체계적 문헌고찰을 시행하였으며, 한약과 양약의 복합치료가 양약 단독치료에 비해 치료효과가 더 높은 것으로 나타났다.

Abstract ▼ AI-Helper

The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that applied herbal medicine to treat viral hepatitis B and C in order to determine the therapeutic efficacy of herbal medicine. EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, and Oasis databases were searched to identify RCTs. The selected studies were assessed by the Cochrane group's risk of bias tool. A total of 15 RCTs were selected, and the hepatitis B virus (HBV) DNA reduction was significantly higher in patients treated with herbal medicine combined with Western medicine than in patients treated with herbal medicine. Herbal medicine combined with Western medicine was also superior to Western medicine alone in achieving hepatitis B e-antigen (HBeAg) and alanine aminotransferase [ALT] reduction. Only herbal medicine alone was not superior to Western medicine treatments in achieving HBV DNA, HBeAg, and ALT reduction.

주제어

표/그림 (17)

그림 Fig. 1. Flow diagram of the selection process.
표 Table 1. Summary of the Randomized Controlled Trials Included in This Study
표 Table 2. Composition of the Herbal Preparations
표 Table 3. The Criteria for Group Division in Chen's Study
그림 Fig. 2. Results of the meta-analysis for hepatitis B virus DNA reduction (herbal medicine vs Western medicine).
그림 Fig. 3. Results of the meta-analysis for hepatitis B virus DNA reduction (herbal medicine vs placebo).
그림 Fig. 4. Results of the meta-analysis for hepatitis B virus DNA reduction (herbal medicine+Western medicine vs Western medicine).
그림 Fig. 5. Results of the meta-analysis for hepatitis B e-antigen reduction (herbal medicine vs Western medicine).
그림 Fig. 6. Results of the meta-analysis for hepatitis B e-antigen loss (herbal medicine+Western medicine vs Western medicine).
그림 Fig. 7. Results of the meta-analysis for hepatitis C virus RNA reduction (herbal medicine vs placebo).
그림 Fig. 8. Results of the meta-analysis for alanine aminotransferase (herbal medicine vs Western medicine).
그림 Fig. 9. Results of meta-analysis for alanine aminotransferase (herbal medicine vs placebo).
그림 Fig. 10. Results of the meta-analysis for alanine aminotransferase (herbal medicine vs diluted herbal medicine).
그림 Fig. 11. Results of the meta-analysis for alanine aminotransferase (herbal medicine+Western medicine vs Western medicine).
그림 Fig. 12. Risk of bias graph.
그림 Fig. 13. Risk of bias summary.
그림 Fig. 14. Contour-enhanced funnel plot. The funnel plot is centered at 0, the value under the null hypothesis of no effect. The region outside of the funnel corresponds to p-values of 0.10.

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