[논문]커큐민이 건강에 미치는 효과 - 재평가

김대옥; 이창용

doi:10.9721/kjfst.2021.53.5.509

커큐민이 건강에 미치는 효과 - 재평가
Effects of curcumin on human health - A reassessment 원문보기

한국식품과학회지 = Korean journal of food science and technology, v.53 no.5, 2021년, pp.509 - 513

초록
AI-Helper

커큐민은 산화방지능, 항염증, 항우울, 항균, 항종양 등의 다양하고 유익한 생리학적 활성이 있는 것으로 알려져 있다. 또한, 커큐민은 면역조절, 대사조절, 신경보호 효과도 가지고 있다. 지난 10년 동안 13,000편 이상의 연구 논문에서 커큐민의 건강상 이점에 대한 연구가 발표되었음에도 불구하고, 아직까지 전 세계 어느 나라에서도 커큐민을 의약품으로 시장에 출시하지 못하고 있다. 긍정적인 결과가 많음에도, 건강상의 이점을 내세우는 대부분의 연구는 커큐민의 다양한 화학적 거동을 고려하지 않은 시험관실험 및 동물실험에 기반으로 하고 있다. 커큐민은 PAINS이자 IMPs 중의 하나로 알려져 있다. 따라서 엄격한 연구 설계에도 불구하고, 인체적용시험 및 임상시험은 특별한 이점을 입증할 수 없었다. 이 논문에서는 커큐민의 다면적 특성을 검토하여 커큐민의 부정적 특성이 이로운 효과와 균형을 이룰 수 있도록 하고 건강상의 이점을 더 잘 이해할 수 있는 잠재적 연구 방법을 제안하고 있다.

Abstract ▼ AI-Helper

Curcumin is known to possess diverse beneficial physiological effects including antioxidant, anti-inflammatory, anti-depressant, anti-microbial, and anti-neoplastic activities, as well as immune-modulating, metabolism-regulating, and neuroprotective effects. However, despite more than 13,000 research papers published during the last ten years regarding the health benefits of curcumin, curcumin has not been introduced in the market as a pharmaceutical agent in any country. Despite the abundance of positive findings, most investigations that tout its health benefits are based on in vitro and in vivo studies that fail to consider the protean chemical behaviors of curcumin, which is known to be a pan-assay interference compound and an invalid metabolic panacea. Therefore, human clinical trials, despite rigorous study design, have been unable to prove specific benefits. This article reviews the pleiotropic properties of curcumin so that they can be balanced against its beneficial effects and suggests potential research avenues to better understand its health benefits.

주제어

표/그림 (3)

그림 Fig. 1. The number of articles published in the journals on curcumin during 1990-2020. The number of articles per year was retrieved from SciFinder by searching for the title "biological studies on curcumin" during 1990-2020.
그림 Fig. 2. Structures of tautomers of curcumin. (A) diketo form in aqueous solution and (B) enol-keto form in organic solvent
그림 Fig. 3. Major curcuminoids of turmeric extract. (A) curcumin (60-70% of turmeric extract), (B) demethoxycurcumin (20-27% of turmeric extract), and (C) bisdemethoxycurcumin (10-15% of turmeric extract) (Nelson et al., 2017)

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