[논문]알츠하이머병 쥐 모델에서 경두개 직류 전기자극의 효용성 검토

김지은; 박예은; 정진형; 이상식

doi:10.17661/jkiiect.2021.14.5.403

[국내논문] 알츠하이머병 쥐 모델에서 경두개 직류 전기자극의 효용성 검토
Review : Effectiveness of transcranial direct current stimulation in rodent models of Alzheimer's disease 원문보기

한국정보전자통신기술학회논문지 = Journal of Korea institute of information, electronics, and communication technology, v.14 no.5, 2021년, pp.403 - 412

김지은 (Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine) , 박예은 (Department of Biomedical Engineering, Catholic Kwandong University) , 정진형 (Department of Biomedical IT, Catholic Kwandong University) , 이상식 (Department of Biomedical Engineering, Catholic Kwandong University)

초록
AI-Helper

알츠하이머병은 치매를 일으키는 원인 중 가장 높은 빈도를 차지하는 신경퇴행성 질환으로서, 아직은 증상을 개선시키는 정도의 약물적 치료가 주를 이룬다. 이러한 경구약제의 치료적 한계성 및 신약개발의 어려움에 직면하여 임상에서는 비약물적 치료에 대한 관심이 높아지고 있다. 경두개 직류전기자극(transcranial direct current stimulation, tDCS)는 낮은 강도의 직류전류를 이용한 비침습적 뇌조절술의 한 종류로서, 그 안전성에 대해서는 이미 널리 입증받은 바 있다. 본 종설에서는 알츠하이머병 쥐 모델에게 tDCS를 적용함으로써 얻을 수 있는 행동학적, 신경생리학적, 뇌조직학적 회복에 대한 객관적 근거들을 살펴봄으로써, 인간 대상 tDCS연구의 배경근거를 제시하고자 한다.

Abstract ▼ AI-Helper

Alzheimer's disease (AD) is the most common cause of dementia, showing progressive neurodegeneration. Although oral medications for symptomatic improvement still take a huge part of treatment, there are several limitations caused by pharmacology-based real world clinic. In this respect, non-pharmacologic treatment for AD is rising to prominence. Transcranial direct current stimulation (tDCS) is a one of the non-invasive neuromodulation technique, using low-voltage direct current. In terms of safety, tDCS already has been proven through numerous previous reports. This review focused on behavioral, neurophysiologic and histopathologic improvement by applying tDCS in AD rodent models, thereby suggesting reliable background evidence for human-based tDCS study.

주제어

표/그림 (6)

그림 그림 1. tDCS Fig. 1. tDCS
표 표 1. 각 그룹의 신경 기능 점수[20] Table 1. The neurological function score in each group[20]
그림 그림 2. Y-maze 실험결과(Control group – 100%, STZ 치매 유도 group – 78%, tDCS treatment group – 86%) Fig. 2. Y-maze Experiment experimental result (Control group – 100%, STZ Dementia Induction group – 78%, tDCS treatment group – 86%)
그림 그림 3. 임상변수에 대한 결과[25] Fig. 3. Results of clinical variables[25]
그림 그림 4. 모든 영역에서 저주파 및 고주차 대역의 qEEG 전력(S-tDCS)[25] Fig. 4. qEEG power in the low-and high-frequency bands at all time points and in all regions of interest(S-tDCS)[25]
그림 그림 5. 모든 영역에서 저주파 및 고주차 대역의 qEEG 전력(A-tDCS)[25] Fig. 5. qEEG power in the low-and high-frequency bands at all time points and in all regions of interest(A-tDCS)[25]

참고문헌 (33)

Moon, Won-Jin. "Alzheimer dementia and microvascular pathology: blood-brain barrier permeability imaging." J Korean Soc Radiol 81 (2020): 488-500.

원문보기 상세보기
Min, Changho, Heonsu Ha, and Jongho Jeon. "Development of Fluorescent Small Molecules for Imaging of Alzheimer's Disease Biomarkers." Applied Chemistry for Engineering 32.1 (2021): 1-9.

원문보기 상세보기
Kim, Seong Yoon. "Past and Future of Drug Treatments for Alzheimer's Disease." Journal of Korean Neuropsychiatric Association 57.1 (2018): 30-42.

상세보기
Kim, Yun-Hee. "Noninvasive brain stimulation: repetitive transcranial magnetic stimulation and transcranial direct current stimulation." Journal of the Korean Medical Association 56.1 (2013): 30-37.

상세보기
Jun-Tae Kim. "A Study on the Evaluation of CASE Clinical Efficiency Using tDCS in the Dementia Animal Experiment Model Group." Domestic doctoral thesis. Catholic Kwandong University Doctoral dissertation (2020).
Kang, Sa Yoon. "Clinical applications of transcranial direct current stimulation in neurological disorders." Journal of the Korean Neurological Association 35.2 (2017): 63-71.

상세보기
Kim, Jun Won, and Jaewon Lee. "Application of transcranial direct current stimulation in psychiatry." Journal of Korean Neuropsychiatric Association 55.3 (2016): 158-167.

상세보기
Priori, Alberto, et al. "Polarization of the human motor cortex through the scalp." Neuroreport 9.10 (1998): 2257-2260.

상세보기
Antal, Andrea, and Walter Paulus. "Transcranial direct current stimulation and visual perception." Perception 37.3 (2008): 367-374.

상세보기
Ferrucci, Roberta, and Alberto Priori. "Transcranial cerebellar direct current stimulation (tcDCS): motor control, cognition, learning and emotions." Neuroimage 85 (2014): 918-923.

상세보기
Oliveira, Janaina F., et al. "Acute working memory improvement after tDCS in antidepressant-free patients with major depressive disorder." Neuroscience letters 537 (2013): 60-64.

상세보기
Kim, Wang-In, et al. "Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation." Brain Sciences 10.8 (2020): 547.

상세보기
Gondard, Elise, et al. "Transcranial direct current stimulation does not improve memory deficits or alter pathological hallmarks in a rodent model of Alzheimer's disease." Journal of psychiatric research 114 (2019): 93-98.

상세보기
Kim, Gi-do, Sim, Ki-Chol, and Kim, Kyung-Yoon. "The effect of transcranial direct current electrical stimulation on the enhancement of forelimb kinesthetic function in a rat model of focal ischemic brain injury." Journal of the Korean Contents Association, 11.4 (2011): 273-282.
Kim, You-Mi, et al. "Effects of treadmill exercise on the 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of the rats with streptozotocin-induced Alzheimer's disease." Journal of Coaching Development 11.1 (2009): 67-75.
Su-Kang Kim, in-hyoung Jeong, Geun-Yong Lee, Woo-Young Jeong and Sang-sik Lee. "A study on the effect of repetitive transcranial magnetic stimulation through Y-maze behavioral experiments in dementia-induced animal models." Korean Electrical Society Vol.2020 No.10 (2020): 427-428.
Cavaleiro, Carla, et al. "Memory and cognition-related neuroplasticity enhancement by transcranial direct current stimulation in rodents: a systematic review." Neural plasticity 2020 (2020).

상세보기
Su-Kang Kim, Jun-Tae Kim, Woo-Young Jeong, Jin-hyoung Jeong, Sang-sik Lee. "A Study on the Evaluation of CASE Clinical Efficiency Using tDCS in the Dementia Animal Experiment Model Group." The Korean Institute of Electrical Engineers INFORMATION AND CONTROL SYMPOSIUM 2020.10, 435-436.
Bederson, Joshua B., Isabelle M. Germano, and Lorraine Guarino. "Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat." Stroke 26.6 (1995): 1086-1092.

상세보기
Lim, Gun-Hong. "The Effects of Task oriented Training on Motor and Cognitive Function in Alzheimer's Dementia Rat." Journal of the Korea Academia-Industrial cooperation Society 20.7 (2019): 119-126.

원문보기 상세보기
Vallee, Monique, et al. "Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus." Proceedings of the National Academy of Sciences 94.26 (1997): 14865-14870.

상세보기
Roghani, Mehrdad, et al. "Time course of changes in passive avoidance and Y-maze performance in male diabetic rats." Iranian Biomedical Journal 10.2 (2006): 99-104.
Kim, Ka-Na, et al. "The protective and recovery effects of Peucedanum Japonicum Thunberg for vascular dementia." Journal of Oriental Neuropsychiatry 24.1 (2013): 123-130

원문보기 상세보기
Khalili, Mohsen, and Faezeh Hamzeh. "Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats." Iranian biomedical journal 14.1-2 (2010): 59.
Ferrucci, Roberta, et al. "Behavioral and neurophysiological effects of transcranial direct current stimulation (tDCS) in fronto-temporal dementia." Frontiers in behavioral neuroscience 12 (2018): 235.

상세보기
Kyungmin Lee. Diagnosis and treatment of memory disorders. Medical POSTGRADUATES 27.6 (1999): 362-367.
Boggio, Paulo Sergio, et al. "Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease." Brain stimulation 5.3 (2012): 223-230.

상세보기
Delorme, Arnaud, and Scott Makeig. "EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis." Journal of neuroscience methods 134.1 (2004): 9-21.

상세보기
Marceglia, Sara, et al. "Transcranial direct current stimulation modulates cortical neuronal activity in Alzheimer's disease." Frontiers in neuroscience 10 (2016): 134.

상세보기
Klimesch, Wolfgang. "EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis." Brain research reviews 29.2-3 (1999): 169-195.

상세보기
Webster, Scott J., et al. "Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models." Frontiers in genetics 5 (2014): 88.

상세보기
Geun-Yong Lee. "A study on the effect of repetitive transcranial magnetic stimulation using the STZ dementia-induced animal model." Domestic doctoral thesis. Catholic Kwandong University Doctoral dissertation (2020).
Su kang Kim, Jin hyeong Jeong, Juntae Kim, Wooyoung Jung, and Sang sik Lee. A study on neuroanatomical differences using tDCS in the dementia animal model group. Korean Electrical Society Vol.2020 No.10 (2020): 425-426.

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증