[논문]박달나무로부터 분리된 페놀성 화합물의 항산화 및 Tyrosinase 저해 활성 연구

왕다혜; 정하숙

doi:10.9799/ksfan.2021.34.5.553

박달나무로부터 분리된 페놀성 화합물의 항산화 및 Tyrosinase 저해 활성 연구
Identification of Anti-Oxidant and Anti-Tyrosinase Activity of Phenolic Components Isolated from Betula schmidtii 원문보기

한국식품영양학회지 = The Korean journal of food and nutrition, v.34 no.5, 2021년, pp.553 - 559

왕다혜 (덕성여자대학교 자연과학대학 화학과) , 정하숙 (덕성여자대학교 자연과학대학 식품영양학과)

Abstract ▼ AI-Helper

The aim of study to investigate the phytochemicals and biological activities the bark of Betula schmidtii. The studies consisted of the solvent extraction, followed by the isolation of phenolic components 1~3 from ethyl acetate-soluble fraction of Betula schmidtii Bark. Their chemical structures were identified as arbutin (1), ρ-coumaric acid (2) and ferulic acid (3) using Ultraviolet-Visible (UV-Vis) Spectrophotometer, Electrospray Ionization Mass Spectrometry (ESI-MS) (negative ion mode), 1H-Nuclear Magnetic Resonance (NMR), 13C-NMR, 1H-1H Correlation Spectroscopy (COSY) and 1H-13C Hetero Nuclear Multiple Quantum Correlation (HMQC) spectral data. Compounds 1~3 shows the anti-oxidant effect with IC50 values of 29.74±1.52, 21.32±1.07 and 34.41±1.24 in 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, respectively. Also, compounds 1~3 exhibited mushroom tyrosinase inhibitory activity with IC50 values of 31.14±1.07, 42.54±1.46 and 69.22±1.43 µM, respectively.

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표/그림 (3)

$Fig. 1. Extraction and solvent fractionation of Betula schmidtii Bark.$ 그림 Fig. 1. Extraction and solvent fractionation of Betula schmidtii Bark.
그림 Fig. 2. Chemical structure of compounds 1~3 isolated from Betula schmidtii Bark.
표 Table 1. DPPH free radical scavenging and tyrosinase inhibitory activity of compounds 1~3 isolated from Betula schmidtii Bark

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박달나무로부터 분리된 페놀성 화합물의 항산화 및 Tyrosinase 저해 활성 연구
Identification of Anti-Oxidant and Anti-Tyrosinase Activity of Phenolic Components Isolated from Betula schmidtii 원문보기

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박달나무로부터 분리된 페놀성 화합물의 항산화 및 Tyrosinase 저해 활성 연구 Identification of Anti-Oxidant and Anti-Tyrosinase Activity of Phenolic Components Isolated from Betula schmidtii 원문보기

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박달나무로부터 분리된 페놀성 화합물의 항산화 및 Tyrosinase 저해 활성 연구
Identification of Anti-Oxidant and Anti-Tyrosinase Activity of Phenolic Components Isolated from Betula schmidtii 원문보기