[논문]Crizotinib과 한방치료를 병행하여 호전된 ROS1 양성 재발성 폐암 환자 1례

장권준; 양정민; 이지윤; 고은비; 문향란; 윤민지; 조온유; 정성헌; 이범준; 신광순; 황우석

doi:10.22246/jikm.2021.42.5.820

Crizotinib과 한방치료를 병행하여 호전된 ROS1 양성 재발성 폐암 환자 1례
A Case Report on ROS1-positive Recurrent Non-small-cell Lung Cancer Treated with Crizotinib and Korean Medicine 원문보기

대한한방내과학회지 = The journal of internal Korean medicine, v.42 no.5, 2021년, pp.820 - 832

장권준 (장덕한방병원) , 양정민 (장덕한방병원) , 이지윤 (장덕한방병원) , 고은비 (장덕한방병원) , 문향란 (장덕한방병원) , 윤민지 (장덕한방병원) , 조온유 (장덕한방병원) , 정성헌 (장덕한방병원) , 이범준 (경희대학교대학원 임상한의학과 폐계내과학교실) , 신광순 (장덕한방병원) , 황우석 (장덕한방병원)

Abstract ▼ AI-Helper

Objectives: This study examined the case of a patient with ROS1-positive recurrent non-small-cell lung cancer treated with crizotinib and traditional Korean medicine. Methods: The patient was treated with crizotinib from January 20 2021 to May 22 2021, together with Haedogyangpye-tang and Haengso-tang. The tumor size was measured using computed tomography (CT), and adverse events were evaluated according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0. Results: After four months of combined treatment, the sizes of the lymph nodes in the porta hepatis, hepatoduodenal, retrocrural, aortocaval, and para-aortic areas had decreased, and no lymph nodes larger than 1 cm in diameter were observed. The side effects of chemotherapy also improved. Conclusions: This case study suggests that traditional Korean medicine may alleviate the side effects of chemotherapy, improve quality of life, and complement chemotherapy itself.

주제어

표/그림 (8)

표 Table 1. Composition of Haedogyangpye-tang
표 Table 2. Composition of Haengso-tang
그림 Fig. 1. Comparison of computed tomography (CT) images before and after treatment. A (2020/12/30) : 1. No change of Hepatic resection site. 2. Increased metastic LNs in the porta hepatis, hepatoduodenal, retrocrural, aortocaval and para-aortic area. B (2021/2/20) : 1. No specific findings in the liver, pancreas, adrenal gland, kidney, GI tract. 2. Decreased previously seen LNs around the portal vein and IVC, No lymph nodes larger than 1 cm in diameter were seen. C (2021/4/15) : 1. No specific findings in the liver, pancreas, adrenal gland, kidney, GI tract. 2. No change of decreased LNs around the portal vein and IVC.
그림 Fig. 2. Comparison of computed tomography (CT) images before and after treatment. A (2020/12/30) : 1. No change in radiation fibrosis of right lung. 2. Both lungs diffuse emphysema. B (2021/2/20) : 1. No change in radiation fibrosis of right lung. 2. Both lungs diffuse emphysema. C (2021/4/15) : 1. No change in radiation fibrosis of right lung. 2. Both lungs diffuse emphysema.
표 Table 3. Laboratory Fidings
그림 Fig. 3. Cough progress : symptom intensity and number of repetitions was measured.
그림 Fig. 4. Diarrhea progress : symptom intensity and number of repetitions was measured.
그림 Fig. 5. Stomatitis progress : symptom intensity was measured by numeric rating scale.

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