[논문]숙지황(熟地黃) 추출물의 치주염 개선 효과 연구

백희경; 김미혜; 양웅모

[국내논문] 숙지황(熟地黃) 추출물의 치주염 개선 효과 연구
Inhibitory effects of the steamed radix of Rehmanniae glutinosa against ligature-induced periodontitis 원문보기

대한융합한의학회지 = Journal of Convergence Korean Medicine, v.4 no.1, 2022년, pp.29 - 36

백희경 (경희대학교 한의과대학) , 김미혜 (우석대학교 한의과대학) , 양웅모 (경희대학교 한의과대학)

Abstract ▼ AI-Helper

Objectives : The purpose of this study was to investigate the anti-inflammatory effects of the aqueous extract of the steamed radix of Rehmanniae glutinosa (SRG) on periodontitis in ligature-induced rat model. Methods: To induce the periodontitis, ligature was placed around the lower first molar in rats. Rats were divided into 4 groups (n = 7), NL (non-ligatured and vehicle-treated), L (ligatured and vehicle-treated), SRG1 (ligatured and 1 mg/kg SRG-treated) and SRG100 (ligatured and 100 mg/kg SRG-treated). Vehicle or SRG solution was applied daily for 14 days and then all experimental rats were sacrificed. To examine the effect of SRG solution on periodontitis, the level of alveolar bone loss, cementum regeneration, gingival tissue degradation, and osteoclast cell numbers were analyzed. Results: Alveolar bone loss was inhibited in ligature-induced periodontitis rats treated with SRG treatment. Histopathological cementum was recovered in SRG1 and SRG100 groups. SRG extract inhibited gingival tissue degradation induced by ligature. In addition, the numbers of osteoclast cells were decreased by treatment SRG in periodontitis rats. Conclusion: Taken together, these results suggest that SRG have inhibitory effects against periodontitis. Therefore, the steamed radix of Rehmanniae glutinosa has may be a potential alternative for periodontitis.

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표/그림 (4)

그림 Figure 1. Effects of SRGs on Alveolar Bone Loss (ABL). (A) Macroscopic tissue images using a ruler and (B) quantified values of ABL. The red lines represent the distance from Cementoenamel Junction (CEJ) to the Alveolar Bone Crest (ABC). ^###p < 0.001 compared to NL; ^***p < 0.001 compared to L, NL, non-ligatured and vehicle-treated; L, Ligatured and vehicle-treated; SRG1, ligatured and 1 mg/kg steamed radix of Rehmanniae glutinosa treated; SRG100, ligatured and 100 mg/kg steamed radix of Rehmanniae glutinosa treated.
그림 Figure 2. Effects of SRGs on histological assessment for perodontal ligament and cementum regeneration. Hematoxylin and Eosin (H&E)-stained images of cementum (the yellow arrows). NL, non-ligatured and vehicle-treated; L, Ligatured and vehicle-treated; SRG1, ligatured and 1 mg/kg steamed radix of Rehmanniae glutinosa treated; SRG100, ligatured and 100 mg/kg steamed radix of Rehmanniae glutinosa treated.
그림 Figure 3. Effects of SRGs on H&E-stained microphotographs of gingival tissues. The blue arrows indicate gingival tissues. ^###p < 0.001 compared to NL; ^*p < 0.01 compared to L, NL, non-ligatured and vehicle-treated; L, Ligatured and vehicle-treated; SRG1, ligatured and 1 mg/kg steamed radix of Rehmanniae glutinosa treated; SRG100, ligatured and 100 mg/kg steamed radix of Rehmanniae glutinosa treated.
그림 Figure 4. Effects of SRGs on TRAP-positive osteoclast cells.

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