[논문]호두 열매 추출물의 메틸글라이옥살 유도 신장 세포손상 억제 효과 및 당화억제 효능

최지원; 최상윤; 유귀재; 허진영

doi:10.7318/kjfc/2022.37.6.503

호두 열매 추출물의 메틸글라이옥살 유도 신장 세포손상 억제 효과 및 당화억제 효능
Antiglycation and Protective Effect of Juglans regia L. in MGO-induced Renal cell Death 원문보기

韓國食生活文化學會誌 = Journal of the Korean Society of Food Culture, v.37 no.6, 2022년, pp.503 - 509

최지원 (한국식품연구원) , 최상윤 (한국식품연구원) , 유귀재 (한국식품연구원) , 허진영 (한국식품연구원)

Abstract ▼ AI-Helper

Methylglyoxal is a highly reactive precursor which forms advanced glycation end products (AGEs). AGEs and methylglyoxal are known to induce various diseases such as diabetes, vascular disorders, Diabetes Mellitus (DM), and neuronal disorders. Juglans regia L is an important food commonly used worldwide, having nutritious components, including phenolic compounds. Since ancient times, Juglans regia L have been differently applied by various countries for health and in diverse diseases, including arthritis, asthma, skin disorders, cancer, and diabetes mellitus. However, the effect of diabetes-induced renal damage against AGEs remains unclear. This study evaluates the anti-glycation and renal protective effects of ethanol extract of Juglans regia L against methylglyoxal-induced renal tubular epithelial cell death. Exposure to methylglyoxal resulted in reduced cell viability in NRK-52E cells, but co-treatment with Juglans regia L extracts significantly increased the cell viability. In addition, we examined the anti-glycation effect of Juglans regia L extracts. Compared to the positive control aminoguanidine and Alagebrium, treatment with Juglans regia L extracts significantly inhibited the formation of AGEs, collagen cross-linking, and breaking collagen cross-linking. Taken together, our results indicate that Juglans regia L is a potential therapeutic agent for regulating diabetic complications by exerting anti-glycation and renal protective activities.

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표/그림 (4)

그림 Effect of JS on MGO-induced renal cell death in NRK-52E cells. NRK-52E cells were treated MGO (Methylgloxal) with or without JS (70% ethanol extract of Juglans regia L) and determined viability using the MTT assay. Statistical analysis was carried out by using one-way ANOVA with Tukey's multiple comparison tests in GraphPad Prism5. Results are expressed as mean±SD of three independent experiments. Normal group vs Control group (^***p<0.001); Control group vs MGO treated group (^##p<0.05. ^###p<0.001)
그림 Effect of AGEs foramtion activity of JS (70% ethanol extract of Juglans regia L) in vitro model. Inhibitory effects of JS on AGEs formation. AG (Aminoguanidine) was used as a positive control for AGEs formation. Statistical analysis was carried out by using one-way ANOVA with Tukey's multiple comparison tests in GraphPad Prism5. Results are expressed as mean±SD of three independent experiments. AGEs group vs JS or AG treated group (^***p<0.001).
그림 Anti-glycation effect of JS (70% ethanol extract of Juglans regia L) on AGEs induced cross-linking formation. AG (Aminoguanidine) was used as a positive control for cross-linking formation. Statistical analysis was carried out by using one-way ANOVA with Tukey's multiple comparison tests in GraphPad Prism5. Results are expressed as mean±SD of three independent experiments. AGEs group vs JS or AG treated group (^***p<0.001).
그림 Effects of the JS on AGEs-induced glycation in vitro. JS (70% ethanol extract of Juglans regia L) attenuated collagen cross-linking. ALT-711 (Alagebrium) were used as positive control Statistical analysis was carried out by using one-way ANOVA with Tukey's multiple comparison tests in GraphPad Prism5. Results are expressed as mean±SD of three independent experiments. AGEs group vs JS or ALT treated group (^***p<0.001).

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호두 열매 추출물의 메틸글라이옥살 유도 신장 세포손상 억제 효과 및 당화억제 효능
Antiglycation and Protective Effect of Juglans regia L. in MGO-induced Renal cell Death 원문보기

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호두 열매 추출물의 메틸글라이옥살 유도 신장 세포손상 억제 효과 및 당화억제 효능 Antiglycation and Protective Effect of Juglans regia L. in MGO-induced Renal cell Death 원문보기

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호두 열매 추출물의 메틸글라이옥살 유도 신장 세포손상 억제 효과 및 당화억제 효능
Antiglycation and Protective Effect of Juglans regia L. in MGO-induced Renal cell Death 원문보기

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