[논문]천연추출물 및 단일물질을 이용한 알러지 염증억제효과 스크리닝

박성아; 장윤성

doi:10.22156/cs4smb.2022.12.02.213

천연추출물 및 단일물질을 이용한 알러지 염증억제효과 스크리닝
Allergic inflammatory inhibitory effect screening using natural extracts and single substances 원문보기

융합정보논문지 = Journal of Convergence for Information Technology, v.12 no.2, 2022년, pp.213 - 220

박성아 (건국대학교 생물공학과) , 장윤성 ((주)장피셜)

초록
AI-Helper

본 연구는 천연추출물 640종류를 이용하여 알러지 염증억제 효과인 IL-6 및 TNF-α의 억제효과를 확인하기 위한 대한 기능적 연구를 수행하였다. 640종 중 100% 세포생존률을 보인 물질은 36종으로 이 중 IL-6 억제효과를 보인 추출물 중 cyclosporin A와 유사한 억제효과를 보인 물질은 8종이고, TNF-α에서는 5종이였다. 특히, IL-6 및 TNF-α에 공통적인 억제효과를 보인 추출물은 2종으로 하고초 및 눈연꽃 추출물에서 알러지 염증억제효과를 보였고, 알러지 염증억제 효과가 강한 것을 알 수 있었다. 이러한 내용은 천연추출물을 이용한 알러지 염증억제 기능성 천연 화장품 소재로 사용될 수 있을 것으로 사료된다.

Abstract ▼ AI-Helper

In this study, a functional study was conducted to confirm the inhibitory effect of IL-6 and TFN-α, which are allergic inflammation inhibitory effects, using natural extracts 640 types of substances. Of the 640 types, 36 substances showed 100% cell viability, and among the extracts showing the IL-6 inhibitory effect, 8 substances showed an inhibitory effect similar to that of cyclosporin A, and 5 substances showed an inhibitory effect on TFN-α. In particular, two types of extracts showing a common inhibitory effect on IL-6 and TFN-α showed an anti-allergic anti-inflammatory effect and a strong anti-allergic anti-inflammatory effect in Hagocho and Snow lotus extract. It is thought that these contents can be used as a functional natural cosmetic material for allergy-inflammation suppression using natural extracts.

주제어

표/그림 (4)

표 Table. 1 More than 100% cell viability of RBL-2H3 cells
그림 Fig. 1. Difference between RBL-2H3 cell viability.
그림 Fig. 2. Difference between IL-6 cytokine inhibitory activity.
그림 Fig. 3. Difference between antiradical parameters: NO radical scavenging activity.

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