[논문]40세 이상 성인 한국인에서 한국형 식사염증지표 수준에 따른 당뇨병 발생률 및 당화혈색소 수준 변화 연구

윤현서; 손진영; 박윤정

doi:10.4163/jnh.2022.55.2.263

40세 이상 성인 한국인에서 한국형 식사염증지표 수준에 따른 당뇨병 발생률 및 당화혈색소 수준 변화 연구
Effects of Korean Food-based Dietary Inflammatory Index Potential on the incidence of diabetes and HbA1c level in Korean adults aged 40 years and older 원문보기

Journal of nutrition and health, v.55 no.2, 2022년, pp.263 - 277

윤현서 (이화여자대학교 임상보건융합대학원 임상보건학과 임상영양전공) , 손진영 (이화여자대학교 신산업융합대학 식품영양학과) , 박윤정 (이화여자대학교 임상보건융합대학원 임상보건학과 임상영양전공)

초록
AI-Helper

본 연구 결과 우리나라 40세 이상 성인에서 FBDI와 당뇨병 발생률 간의 상관성은 없었으나 당화혈색소 수준과 상관관계를 가지고, 이러한 경향은 여성이거나 운동을 하지 않는 사람, 그리고 비만인 경우 영향을 더 많이 받는다는 결과를 도출해냈다. 이는 앞으로 우리나라 당뇨병 관리 측면에서 염증을 고려한 다각화된 임상영양치료의 발판이 되리라 사료된다. 또한 추후 장기간의 추적 연구를 통해 식사염증지표와 당뇨병의 발생에 대한 추가적인 연구가 필요한 것으로 보이며, 당뇨병의 심각성에 관한 연구는 거의 없는 실정이기 때문에 추후 연구가 반드시 필요하다고 사료된다. 본 연구를 발판 삼아 추가적인 연구를 기반으로 임상현장에서 식사염증지표가 당뇨병 관리 도구로 활용될 수 있기를 기대하는 바이다.

Abstract ▼ AI-Helper

Purpose: The present study examined the associations of Korean Food-based Index of Dietary Inflammatory Potential (FBDI) scores with the prevalence of diabetes and hemoglobin A1c (HbA1c) level of diabetes patients in Korean adults. Methods: The Korean Genome and Epidemiology Study (KoGES) Health Examinee baseline data, collected between 2004 and 2013 and followed up between 2012 and 2016, were used in our study. A total 56,391 participants including diabetes (n = 5,733) and non-diabetes (n = 50,658) were analyzed. The subjects were classified into quartiles of FBDI scores using the semi-quantitative food-frequency questionnaire developed for KoGES. The prevalence rate of diabetes under FBDI scores was assessed by Cox proportional risk models and the severity of the diabetes was analyzed by multiple regression analysis. Results: There were 775 incident cases of diabetes after a mean follow-up of 3.97 years. There was no statistically significant association between FBDI scores and incidence of diabetes. Among diabetes patients at baseline, FBDI scores were related to the risk of progression of diabetes which was represented by greater than 9% HbA1c (Q1 vs. Q4; odds ratio, 1.562 [95% confidence intervals, 1.13-2.15]; p for trend = 0.007). The stratified analysis showed a stronger association in females, irregular exercise group, and higher body mass index group. Conclusion: These results suggest that a pro-inflammatory diet is not associated with the incidence of diabetes but is related to the HbA1c level of diabetes patients. Thus, further longitudinal studies with longer periods are required to determine a relationship between dietary inflammatory index and diabetes in Korea.

주제어

표/그림 (6)

그림 Fig. 1. A fow chart of the study subjects. FBDI, Food-based Index of Dietary Infammatory Potential; KoGES, Korean Genome and Epidemiology Study; HEXA, Health Examinee; FFQ, food-frequency questionnaire; HbA1c, hemoglobin A1c.
표 Table 1. Baseline general characteristics according to FBDI quartiles in KoGES-HEXA 2004–2013
표 Table 2. HRs and 95% CIs for the relation between the FBDI and incidence of diabetes at KoGES-HEXA study
표 Table 3. Population characteristics by HbA1c level among diabetes patients in KoGES-HEXA 2004–2013
표 Table 4. ORs and 95% CIs for the relation between FBDI and HbA1c level among diabetes patients in KoGES-HEXA study
표 Table 5. ORs and 95% CIs for the relation between FBDI and HbA1c level among diabetes patients stratifed by sex, physical activity, and BMI level

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