[논문]Herbal Medicine for Pediatric Epilepsy: Clinical Research Trends in Traditional Chinese Medicine

Kim, Sang-Ho; Kim, Da-Woon

doi:10.7231/jon.2022.33.2.181

Herbal Medicine for Pediatric Epilepsy: Clinical Research Trends in Traditional Chinese Medicine 원문보기

동의신경정신과학회지 = Journal of oriental neuropsychiatry, v.33 no.2, 2022년, pp.181 - 214

Kim, Sang-Ho (Department of Neuropsychiatry of Korean Medicine, Pohang Korean Medicine Hospital, Daegu Haany University) , Kim, Da-Woon (Department of Neuropsychiatry of Korean Medicine, Pohang Korean Medicine Hospital, Daegu Haany University)

Abstract ▼ AI-Helper

Pediatric epilepsy, a chronic, recurrent brain disorder, is the most common neurological disorder in children. Its prevalence is increasing. Early management is very important since 30~40% of cases persist into adulthood. To provide basic data for future clinical research on pediatric epilepsy using Korean medicine treatment and cooperation between Western medicine doctors and Korean medicine doctors, we reviewed recent clinical research in traditional Chinese medicine (TCM) using herbal medicine for pediatric epilepsy. A total of 23 articles (1 clinical practice guideline, 3 systematic reviews, 15 randomized controlled trials (RCTs), and 4 non-RCTs) were reviewed in this study. The authors summarized characteristics of included studies regarding study subjects, diagnostic tools, pattern identification tools, treatment period, evaluation tools, detail of herbal medicines, treatment effects, and adverse events. Combination therapy using both herbal medicine (HM) and anti-epileptic drugs (AEDs) was performed more frequently than herbal medicine alone. Liver-pacifying medicinal, water-draining medicine, and orifice-opening medicine were frequently used. The main single HMs were Cheonma, Boglyeong, Jogudeung, and Seogchangpo. Combined therapy using HM and AEDs had significant benefits in improving total effective rate. It also appeared to be safer than AEDs. However, since the quality of clinical trials was poor and only studies in the last 10 years were included, the clinical evidence was uncertain. Finally, the authors provided limitations of this study and several suggestions for future research based on our analysis results.

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표/그림 (13)

표 Table 1. Searching Strategy
그림 Fig. 1. Flow chart of the study selection process. AED: antiepileptic drug, CPG: clinical practice guideline, HM: herbal medicine, RCT: randomized controlled trials, SR: systematic review.
표 Table 2. The Summary of Included Clinical Practice Guideline
표 Table 3. Descriptive Summary of the Included Systematic Reviews
표 Table 4. The Characteristics of Included Randomized Controlled Trials
표 Table 4. Continued 1
표 Table 5. Thecharacteristics of Included Non-Randomized Controlled Trials
표 Table 6. Adverse effects of Included Study
표 Table 7. AMSTAR Checklist Assessment of the Included Reviews
그림 Fig. 2. (A) Risk of bias summary. Low, unclear, and high risk, respectively, are represented with the following symbols: "+", "?", and "-". (B) Risk of bias graph. Review of authors' judgments about each risk-of-bias item presented as percentages.
그림 Fig. 3. (A) RoBANS summary. Low, unclear, and high risk, respectively, are represented with the following symbols: "+", "?", and "-". (B) RoBANS graph. Review of authors’ judgments about each risk-of-bias item presented as percentages. RoBANS: Risk of Bias Assessment tool for Non-randomized Study.
그림 Fig. 4. Forest plots for comparison of TER between herbal medicine and psychotropic drug groups. Sensitivity analysis after (A) combined therapy with HM and AED (B) monotherapy with HM. AEDs: antiepileptic drugs, HM: herbal medicine, TER: total effective response.
그림 Fig. 5. Forest plots for comparison of TER between herbal medicine and psychotropic drug groups. Sensitivity analysis after (A) combined therapy with HM and AED (B) monotherapy with HM. AEDs: antiepileptic drugs, HM: herbal medicine, TER: total effective response.

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